Clioquinol or Iodochlorhydroxyquin or 5-Chloro-7-iodoquinolin-8-ol or Chinoform Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Clioquinol or Iodochlorhydroxyquin Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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Clioquinol or Iodochlorhydroxyquin or 5-Chloro-7-iodoquinolin-8-ol or Chinoform: CAS Number: 130-26-7, EINECS EC Number: 204-984-4, Molecular Formula: C9H5ClINO, Molecular Weight: 305.50, HS Code ---**

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Clioquinol or Iodochlorhydroxyquin or 5-Chloro-7-iodoquinolin-8-ol or Chinoform.

Clioquinol or Iodochlorhydroxyquin is an antifungal drug and antiprotozoal drug. It is neurotoxic in large doses. It is a member of a family of drugs called hydroxyquinolines which inhibit certain enzymes related to DNA replication. The drugs have been found to have activity against both viral and protozoal infections.

Clioquinol BP Ph Eur Grade
C9H5ClINO --- 305.5 --- CAS 130-26-7
Action and use: Antibacterial; antiprotozoal.

DEFINITION
5-Chloro-7-iodoquinolin-8-ol.
Content: 98.0 per cent to 102.0 per cent (dried substance).

CHARACTERS
Appearance: Almost white, light yellow, brownish-yellow or yellowish-grey powder.
Solubility: Practically insoluble in water, sparingly soluble in methylene chloride, very slightly soluble or slightly soluble in ethanol (96 per cent).

IDENTIFICATION
First identification: B.
Second identification: A, C, D
A. Dissolve 40.0 mg in methanol and dilute to 100.0 mL with the same solvent. Dilute 10.0 mL to 100.0 mL with methanol (solution A). Examined between 280 nm and 350 nm, solution A shows an absorption maximum at 321 nm. Dilute 10.0 mL of solution A to 100.0 mL with methanol (solution B). Examined between 230 nm and 280 nm, solution B shows an absorption maximum at 255 nm. The specific absorbance at this absorption maximum is 1530 to 1660.
B. Infrared absorption spectrophotometry.
C. When heated, violet fumes are produced.
D. Dissolve about 1 mg in 5 mL of ethanol (96 per cent). Add 0.05 mL of ferric chloride solution. A dark green colour develops.

TESTS
Acidity or alkalinity: Shake 0.5 g with 10 mL of carbon dioxide-free water and filter. To the filtrate add 0.2 mL of phenolphthalein solution. The solution is colourless. Not more than 0.5 mL of 0.01 M sodium hydroxide is required to change the colour of the indicator to pink.
Related substances: Liquid chromatography. to pass the test.
Halides: Maximum 140 ppm, expressed as chlorides.
Loss on drying: Maximum 0.5 per cent, determined on 1.000 g by drying over diphosphorus pentoxide at a pressure not exceeding 0.7 kPa for 24 h.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.

ASSAY
Dissolve 0.200 g in 20 mL of acetic anhydride and add 30 mL of glacial acetic acid. Titrate with 0.1 M perchloric acid, determining the end-point potentiometrically. 1 mL of 0.1 M perchloric acid is equivalent to 30.55 mg of total quinolines, calculated as clioquinol.

IMPURITIES
Specified impurities: A, B, C.
A. 5-chloroquinolin-8-ol,
B. 5,7-dichloroquinolin-8-ol,
C. 5,7-diiodoquinolin-8-ol.

Clioquinol USP Grade
C9H5ClINO --- 305.50
8-Quinolinol, 5-chloro-7-iodo-.
5-Chloro-7-iodo-8-quinolinol [CAS 130-26-7].

Clioquinol, dried over phosphorus pentoxide for 5 hours, contains not less than 93.0 percent and not more than 100.5 percent of C9H5ClINO (the 5-chloro-7-iodo-8-quinolinol isomer).

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

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Clioquinol or Iodochlorhydroxyquin SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 10-Oct-20

Product Name & Other Names: Clioquinol or Iodochlorhydroxyquin or 5-Chloro-7-iodoquinolin-8-ol or Chinoform.
CAS No.: 130-26-7
EINECS EC Code: 204-984-4
Molecular Weight: 305.50
Chemical Formula: C9H5ClINO
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Acute toxicity, Oral (Category 3) H301
Skin corrosion (Category 1B) H315
Eye irritation (Category 2) H319
Respiratory sensitization (Category 1) H335

Hazard Statements:
H301: Toxic if swallowed
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Precautionary Statements
P202: Do not handle until all safety precautions have been read and understood.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310+330: IF SWALLOWED: Rinse mouth and immediately call a POISON CENTER or doctor/physician.
P303 + P361 + P352: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Wash with plenty of soap and water.
P304 + P341 + P311: IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P314: Get Medical advice/attention if you feel unwell.
P337+P313: If eye irritation persists: Get medical advice/ attention.
P360: Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container in accordance with local/regional/national/international regulations.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbols:
T Toxic
Xi Irritant
Risk Phrases:
R25 Toxic if swallowed.
R36/37/38 Irritating to eyes, respiratory system and skin.

Product Name/Synonyms: Clioquinol or Iodochlorhydroxyquin or 5-Chloro-7-iodoquinolin-8-ol or Chinoform.
CAS No.: 130-26-7
EINECS EC Code: 204-984-4

Inhalation: If inhaled, it will cause irritation and damage. Remove the victim to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Contact medical center quickly. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: It can cause severe irritation and harm to eyes. Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Get medical attention.

Fire: Toxic fumes, hydrogen iodide, hydrogen chloride, carbon dioxide and carbon monoxide may be formed in fire.
Explosion: No data available
Fire Extinguishing Media: Dry chemical, foam or carbon dioxide and water spray jet.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode.

Personal precautions, protective equipment and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil or water sources.
Methods and materials used for containment Cleanup procedures and Storage:
Small Spill: Sweep and shovel and dispose of as hazardous waste. Keep in suitable, closed containers for disposal. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill: Contain spilled material. Sweep and shovel and dispose of as hazardous waste. Keep in suitable, closed containers for disposal. Avoid dust/mist formation. Keep away from heat. Keep away from sources of ignition. Contact Environment Agency. Wear full protective equipment and ensure proper ventilation.

Precautions for safe handling: Toxic. Do not swallow. Apply according to good manufacturing and industrial hygiene practices. Avoid prolonged or repeated exposure. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat or smoke while handling. Avoid contact with skin, eyes and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents, strong acids, acid chlorides, acid anhydrides. Containers may be hazardous when empty since they retain product residues. Store away from foodstuffs.

Airborne Exposure Limits: Not established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to the substance is apparent and engineering controls are not feasible, consult an industrial hygienist. For emergencies, or instances where the exposure levels are not known, use a full-face piece positive-pressure, air-supplied respirator. WARNING: Air purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: Almost white, light yellow, brownish-yellow or yellowish-grey powder.
Odor: Not available.
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Melting Point: 172C-181C literature.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Practically insoluble in water, sparingly soluble in methylene chloride, very slightly soluble or slightly soluble in ethanol (96 per cent).
Viscosity: Not available.
Molecular Weight: 305.50
Chemical Formula: C9H5ClINO

Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: Toxic fumes, hydrogen iodide, hydrogen chloride, carbon dioxide and carbon monoxide may be formed in fire.
Hazardous Polymerization: Not reported.
Incompatibilities: Strong oxidizing agents, Strong acids, Acid chlorides, Acid anhydrides.
Conditions to Avoid: Heat, flames, moisture, light, ignition sources and incompatibles.

Oral rat LD50: >5000 mg/kg.
Intraperitoneal rat LD50: 3400 mg/kg.
Carcinogenicity: Not reported as carcinogen by any agency.
Reproductive Toxicity: No information available.
Developmental Effects: No information available.
Teratogenicity: No information available.

Persistence and Degradability: No information available.
Bioaccumulation/ Accumulation: No information available.
Mobility: Will likely be mobile in the environment due to its volatility.
Results of PBT and vPvB assessment: No information available.
Environmental Toxicity: No information available.

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.

DOT (USA) & ADR/RID Europe
UN Number: UN 2811
Proper shipping name: TOXIC SOLIDS, ORGANIC, N.O.S. (Clioquinol)
Class: 6.1, Packing group: III
IMDG & IATA
UN Number: UN 2811
Proper shipping name: TOXIC SOLIDS, ORGANIC, N.O.S. (Clioquinol)
Class: 6.1, Packing group: III

USA:
SARA 311/312: Acute & Chronic Health Hazard. See section 2.
California Prop 65: Not applicable.

European Labeling in Accordance with EC Directives:
H301: Toxic if swallowed
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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