Insoluble Saccharin BP EP Ph Eur USP NF FCC Food Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Insoluble Saccharin, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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The participating units have one or more accreditations like FDA - cGMP and GLP approval, ISO-9001 Certified, "REACH" Registered, ISO-14001, ISO/IEC 17025, ISO-22000, FSSC 22000, ISO 45001, Kosher Certified, Halal Certified, HACCP, FSSAI. We offer Commercial Pure & IP BP EP Ph Eur USP NF JP FCC Food Grade Analytical Reagent Grades of Chemicals
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Insoluble saccharin

Insoluble Saccharin: CAS Number: 81-07-2, EINECS EC Number: 201-321-0, Molecular Formula: C7H5NO3S, Molecular Weight: 183.18, HS Code ---**

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For SDS MSDS Sheet Click
SDS MSDS Sheet of Insoluble Saccharin Manufacturers

Spanish Sacarina insoluble Fabricantes

Portuguese Sacarina Insolúvel Fabricantes

Insoluble Saccharin
BP EP Ph Eur USP NF FCC Food Grade Suppliers

Saccharin is primarily produced in two types i.e. soluble and insoluble saccharin. The soluble saccharin (in water) is called Sodium Saccharin whereas insoluble saccharin is called Insoluble Saccharin.

Saccharin is produced in two physical forms, viz granular and powder
Saccharin is used in a variety of industry such as food and beverage, personal care products, table top sweetener, electroplating brighteners, pharmaceuticals etc.

Insoluble Saccharin:
Saccharin is an artificial that is about 300–400 times as sweet as sucrose but has a bitter or after-taste. It is used to sweeten products such as drinks, candies, cookies, and medicines. Saccharin has no food energy and no nutritional value. It is safe to consume for individuals with diabetes.

General Specifications of Insoluble Saccharin
: 81-07-2
Chemical Name: 1,2-benzisothiazolin-3(2H)-one 1,1-dioxide.
Molecular Formula: C7H5NO3S
Molecular Weight: 183.18
Description: White crystals or white, crystalline powder odourless or with a faint, aromatic odour.
Solubility: Sparingly soluble in boiling water and in ethanol (95%); slightly soluble in chloroform, in cold water and in ether. It dissolvers in dilute ammonia solution, in solutions of alkali hydroxides and carbonates.
Melting range: 226 -230C.
Loss on drying: Not more than-1.0%
Heavy metals: Not more than 20 ppm.
OTS Amide content: Not more than 200 ppm
Sulphated ash: Not more than 0.10%.
Assay: Not less than 98.0% and not more than 101.0% on dried substance.

Saccharin BP EP Ph Eur USP NF Grade is also offered. As per the monograph of Saccharin BP EP Ph Eur its content analyses between 99 to 101% assay and meets the requirement of trace impurities specified in the monograph.

Saccharin USP NF Grade Specifications
C7H5NO3S 183.19
1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide.
1,2-Benzisothiazolin-3-one 1,1-dioxide [CAS 81-07-2].

Saccharin contains not less than 99.0 percent and not more than 101.0 percent of C7H5NO3S, calculated on the dried basis.

Packaging and storage: Preserve in well-closed containers. Store at room temperature.

Clarity of solution: [NOTE: The Test solution is to be compared to Reference suspension A and to water in diffused daylight 5 minutes after preparation of Reference suspension A.]
Hydrazine solution: Transfer 1.0 g of hydrazine sulfate to a 100-mL volumetric flask, dissolve in and dilute with water to volume, and mix. Allow to stand for 4 to 6 hours.
Methenamine solution: Transfer 2.5 g of methenamine to a 100-mL glass-stoppered flask, add 25.0 mL of water, insert the glass stopper, and mix to dissolve.
Primary opalescent suspension: [NOTE: This suspension is stable for 2 months, provided it is stored in a glass container free from surface defects. The suspension must not adhere to the glass and must be well mixed before use.] Transfer 25.0 mL of Hydrazine solution to the Methenamine solution in the 100-mL glass-stoppered flask. Mix, and allow to stand for 24 hours.

Opalescence standard: [NOTE: This suspension should not be used beyond 24 hours after preparation.] Transfer 15.0 mL of the Primary opalescent suspension to a 1000-mL volumetric flask, dilute with water to volume, and mix.
Reference suspensions: Transfer 5.0 mL of the Opalescence standard to a 100-mL volumetric flask, dilute with water to volume, and mix to obtain Reference suspension A. Transfer 10.0 mL of the Opalescence standard to a second 100-mL volumetric flask, dilute with water to volume, and mix to obtain Reference suspension B.
Test solution: Dissolve 5.0 g of test material in about 20 mL of a 200 g per L solution of sodium acetate, dilute with the same solution to 25 mL, and mix.
Procedure: Transfer a sufficient portion of the Test solution to a test tube of colorless, transparent, neutral glass with a flat base and an internal diameter of 15 mm to 25 mm to obtain a depth of 40 mm.
Similarly transfer portions of Reference suspension A, Reference suspension B, water, and a 200 g per L solution of sodium acetate to separate matching test tubes. Compare the Test solution, Reference suspension A, Reference suspension B, water, and a 200 g per L solution of sodium acetate in diffused daylight, viewing vertically against a black. [NOTE—The diffusion of light must be such that Reference suspension A can readily be distinguished from water and that Reference suspension B can readily be distinguished from Reference suspension A.] The Test solution shows the same clarity as that of water, or the 200 g per L solution of sodium acetate, or its opalescence is not more pronounced than that of Reference suspension A.

Color of solution:
Standard stock solution: Combine 3.0 mL of ferric chloride, 3.0 mL of cobaltous chloride, 2.4 mL of cupric sulfate, and 1.6 mL of dilute hydrochloric acid (10 g per L).
Standard solution: [NOTE: Prepare the Standard solution immediately before use.] Transfer 1.0 mL of Standard stock solution to a 100-mL volumetric flask, dilute with dilute hydrochloric acid (10 g per L) to volume, and mix.
Test solution: Use the Test solution from Clarity of solution.
Procedure: Transfer a sufficient portion of the Test solution to a test tube of colorless, transparent, neutral glass with a flat base and an internal diameter of 15 mm to 25 mm to obtain a depth of 40 mm.
Similarly transfer portions of the Standard solution, a 200 g per L solution of sodium acetate, and water to separate matching test tubes. Compare the Test solution, the Standard solution, a 200 g per L solution of sodium acetate, and water in diffused daylight, viewing vertically against a white background. The Test solution has the appearance of water or the 200 g per L solution of sodium acetate, or is not more intensely colored than the Standard solution.

Identification: Infrared Absorption 197K .
Melting range: between 226C and 230C.
Loss on drying: Dry it at 105C for 2 hours: it loses not more than 1.0% of its weight.
Readily carbonizable substances: Dissolve 200 mg in 5 mL of sulfuric acid (between 94.5% and 95.5% [w/w] of H2SO4), and keep at a temperature of 48C to 50C for 10 minutes: the solution has no more color than Matching Fluid A, when viewed against a white background.
Residue on ignition: not more than 0.2%. Ignition temperature: 600C ± 50C.
Heavy metals: 0.001%.
Limit of toluenesulfonamides:
Internal standard solution: Dissolve 25 mg of caffeine in methylene chloride, and dilute with the same solvent to 100 mL.
Reference solution: Dissolve 20.0 mg of USP o-Toluenesulfonamide and 20.0 mg of USP p-Toluenesulfonamide in methylene chloride, and dilute with the same solvent to 100.0 mL. Dilute 5.0 mL of the solution with methylene chloride to 50.0 mL. Evaporate 5.0 mL of the final solution to dryness in a stream of nitrogen. Dissolve the residue in 1.0 mL of the Internal standard solution.
Test solution: Suspend 10.0 g of the substance to be examined in 20 mL of water, and dissolve using 5 mL to 6 mL of 10 N sodium hydroxide. If necessary, adjust the solution with 1 N sodium hydroxide or 1 N hydrochloric acid to a pH of 7 to 8, and dilute with water to 50 mL. Shake the solution with four quantities each of 50 mL of methylene chloride. Combine the lower layers, dry over anhydrous sodium sulfate, and filter. Wash the filter and the sodium sulfate with 10 mL of methylene chloride. Combine the solution and the washings, and evaporate almost to dryness in a water bath at a temperature not exceeding 40C. Using a small quantity of methylene chloride, quantitatively transfer the residue into a suitable 10-mL tube, evaporate to dryness in a stream of nitrogen, and dissolve the residue in 1.0 mL of the Internal standard solution.
Blank solution: Evaporate 200 mL of methylene chloride to dryness in a water bath at a temperature not exceeding 40C. Dissolve the residue in 1 mL of methylene chloride.
Chromatographic system: The gas chromatograph is equipped with a flame-ionization detector and contains a 0.53-mm × 10-m fused silica column, coated with G3 phase (film thickness 2 Gm). The injection port, column, and detector temperatures are maintained at about 250C, 180C, and 250C, respectively; and nitrogen is used as the carrier gas at a flow rate of about 10 mL per minute. The injector employs a split ratio of 1:2.
Procedure: Inject about 1 GL of the Reference solution. Adjust the sensitivity of the detector so that the height of the peak due to caffeine is not less than 50% of the full scale of the recorder. The substances are eluted in the following order: o-toluenesulfonamide, p-toluenesulfonamide, and caffeine. The test is not valid unless the resolution between the peaks due to o-toluenesulfonamide and p-toluenesulfonamide is at least 1.5. Inject about 1 GL of the Blank solution. In the chromatogram obtained, verify that there are no peaks with the same retention times as the internal standard, otoluenesulfonamide, and p-toluenesulfonamide. Inject about 1 GL of the Test solution and 1 GL of the Reference solution. If any peaks due to o-toluenesulfonamide, and p-toluenesulfonamide appear in the chromatogram obtained with the Test solution, the ratio of their areas to that of the internal standard is not greater than the corresponding ratio in the chromatogram obtained with the Reference solution (10 ppm of o-toluenesulfonamide and 10 ppm of p-toluenesulfonamide).

Limit of benzoate and salicylate: To 10 mL of a hot, saturated solution of it add ferric chloride, dropwise: no precipitate or violet color appears in the liquid.
Assay: Accurately weigh about 500 mg of Saccharin, dissolve in 40 mL of alcohol, add 40 mL of water, mix, add phenolphthalein, and titrate with 0.1 N sodium hydroxide. Perform a blank titration, if necessary, and make the appropriate correction. Each mL of 0.1 N sodium hydroxide is equivalent to 18.32 mg of C7H5NO3S.

Saccharin FCC Food Grade Specifications
o-Benzosulfimide; Gluside; 1,2-Benzisothiazole-3(2H)-one-1,1-dioxide
C7H5NO3S Formula weight 183.18
INS: 954 CAS 81-07-2

Saccharin occurs as white crystals or as a white, crystalline powder. Its solutions are acid to litmus. One gram is soluble in 290 mL of water at 25C, in 25 mL of boiling water, and in 30 mL of alcohol. It is slightly soluble in chloroform and in ether, and it is readily dissolved by dilute solutions of ammonia, solutions of alkali hydroxides, or solutions of alkali carbonates with the evolution of carbon dioxide.
Function: Nonnutritive sweetener.

A. Dissolve about 100 mg of sample in 5 mL of a 1:20 solution of sodium hydroxide, evaporate the mixture to dryness and gently fuse the residue over a small flame until ammonia no longer evolves. After the residue has cooled, dissolve it in 20 mL of water, neutralize the solution with 2.7 N hydrochloric acid, and filter. Add 1 drop of ferric chloride to the filtrate. A violet color appears.
B. Mix 20 mg of sample with 40 mg of resorcinol, cautiously add 10 drops of sulfuric acid, and heat the mixture in a liquid bath at 200C for 3 min. After cooling, add 10 mL of water and an excess of 1 N sodium hydroxide. A fluorescent green liquid results.
Assay: Not less than 98.0% and not more than 101.0% of C7H5NO3S after drying.
Benzoic and Salicylic Acids: Passes test.
Lead: Not more than 2 mg/kg.
Loss on Drying: Not more than 1%.
Melting Range: Between 226° and 230C.
Readily Carbonizable Substances: Passes test.
Residue on Ignition: Not more than 0.2%.
Selenium: Not more than 0.003%.
Toluenesulfonamides: Not more than 0.0025%.

We also manufacture and supply as under:

Aspartame Acesulfame

Acesulfame Potassium


Calcium Saccharin

Collagen Peptide



Sodium Saccharin




Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +912223770100, +912223726950
Current Date Time in India GMT+5:30


USA, Canada, Mexico and other American
neighbouring buyers may
Call toll-free 1-877-682-9243 (1-877-MUBYCHEM)

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Last 13 May, 2024

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Insoluble Saccharin SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet


Product Name & Other Names: Insoluble Saccharin.
CAS Number: 81-07-2
EINECS EC Number: 201-321-0
Molecular Weight: 183.18
Molecular Formula: C7H5NO3S
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.


GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Labeling according to GHS & Regulation (EC) No 1272/2008

GHS Label Elements

Signal Words: None

Hazards not otherwise classified (HNOC):
May causes mild skin irritation.
May causes mild eye irritation.Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352 - IF ON SKIN: Wash with plenty of soap and water.
P303+P361+P353 - IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.


Product Name & Other Names: Insoluble Saccharin.
CAS Number: 81-07-2
EINECS EC Number: 201-321-0


Always get medical attention after the first aid is over.

Emergency and First Aid Procedures:
Eyes - Flush with water for at least 15 minutes, raising and lowering eyelids occasionally. Get medical attention if irritation persists.
Skin - Thoroughly wash exposed area for at least 15 minutes. Remove contaminated clothing. Launder contaminated clothing before reuse. Get medical attention if irritation persists.
Ingestion - If Insoluble Saccharin is swallowed, if conscious, give plenty of water. Immediately call a physician. Never give anything by mouth to an unconscious person.
Inhalation - Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Get medical attention.


Extinguisher Media: Water spray. Carbon dioxide (CO 2). Dry chemical. alcohol-resistant foam.
Flammable Limits in Air % by Volume: N/A
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.


Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage: Do not inhale vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.


Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents.


Exposure Guidelines: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies. Better keep it under 10 mg/m3
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.


Appearance: White Powder.
Odor: Odorless.
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Melting Point: Melting point/range: 226 - 229C.
Boiling Point: 389C.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Slight
Viscosity: Not available.
Molecular Weight: 183.18
Molecular Formula: C7H5NO3S


Stability: Stable under normal conditions.
Conditions to Avoid: Heat and Strong oxidizing agents.
Incompatibility (Materials to Avoid): Strong oxidizing.
Hazardous Decomposition Products: Carbon oxides, Nitrogen oxides (NOx), Sulphur oxides.
Hazardous Polymerization: Will not occur.


LD50 Oral - Mouse - 17,000 mg/kg
Carcinogenicity: No product present at levels greater than or equal to 0.1% is identified as probable, possible, or confirmed human carcinogen by NTP, ACGIH & OSHA. It is a Group 3: Not classifiable as to its carcinogenicity to humans as per IARC.
Teratogenic Effects: Not available.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.


Toxicity to fish: flow-through test LC50 - Pimephales promelas (fathead minnow) - 18,300 mg/l - 96 h
Toxicity to fish: No information available.
Persistence and Degradability: No information available.
Mobility: No information available.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.


Waste Disposal Methods: Dispose in accordance with all applicable Federal, State and Local regulations.


DOT USA, TDG Canada & ADR/RID Europe: Not regulated.
IMDG/IMO: Not regulated.
IATA: Not regulated.


SARA 302 Components
: SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components: Listed.
SARA 311/312 Hazards: No SARA Hazards
California Prop. 65 Components: This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.


Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.