Aspartame Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Aspartame, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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Aspartame or Asp-Phe methyl ester or L-Phenylalanine, N-L- -aspartyl-, 1-methyl ester: CAS Number: 22839-47-0, EINECS EC Number: 245-261-3, Molecular Formula: C14H18N2O5, Molecular Weight: 294.31, HS Code 29224990 or 29224290

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Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Aspartame or Asp-Phe methyl ester or L-Phenylalanine, N-L- -aspartyl-, 1-methyl ester.

For SDS MSDS Sheet Click
SDS MSDS Sheet of Aspartame Manufacturers

L-Phenylalanine, N-L- -aspartyl-, 1-methyl ester Pure Suppliers

Aspartame is an artificial non-saccharide sweetener 200 times sweeter than sucrose and is commonly used as a sugar substitute in foods and beverages. t is a methyl ester of the aspartic acid/phenylalanine dipeptide. Aspartame is approved for use in food products by most countries. It has an E number of E951.

Properties and General Specifications of Aspartame or Asp-Phe methyl ester:
Appearance: White solid.
Assay: 99% minimum.
Odor: Odorless
Melting point: 246C - 247C
Boiling point: decomposes.
Relative density: 1.35
Solubility: Sparingly soluble; Slightly soluble in ethanol.

Aspartame USP NF Grade:
C14H18N2O5 --- 294.30
L-Phenylalanine, N-L- -aspartyl-, 1-methyl ester.
3-Amino-N-( -carboxyphenethyl)succinamic acid N-methyl ester --- 22839-47-0.

Aspartame contains not less than 98.0 percent and not more than 102.0 percent of C14H18N2O5, calculated on the dried basis.

Packaging and storage: Preserve in well-closed containers.
Identification: Do not dry specimens.
Transmittance: The transmittance of a 1 in 100 solution of it in 2 N hydrochloric acid, prepared by means of sonication, determined in a 1-cm cell at 430 nm with a suitable spectrophotometer, is not less than 0.95, corresponding to an absorbance of not more than about 0.022.
Specific rotation: between +14.5 and +16.5 , determined at 20 within 30 minutes after preparation of the solution.
Test solution: 40 mg per mL, in 15 N formic acid.
Loss on drying: Dry it at 105 for 4 hours: it loses not more than 4.5% of its weight.
Residue on ignition: not more than 0.2%.
Heavy metals: 0.001%.
Limit of 5-benzyl-3,6-dioxo-2-piperazineacetic acid: To pass the test.
Chromatographic purity: To pass the test --- corresponding to not more than 2.0% of chromatographic impurities.
0.1 N Perchloric acid: Use perchloric acid, tenth-normal (in glacial acetic acid) as specified under Volumetric Solutions in the section Reagents, Indicators, and Solutions, but in the standardization, titrate to a green endpoint.
Procedure: Transfer about 300 mg of Aspartame, accurately weighed, to a 150-mL beaker, dissolve in 1.5 mL of anhydrous formic acid, and add 60 mL of glacial acetic acid. Add crystal violet, and immediately titrate with 0.1 N Perchloric acid to a green endpoint. Perform a blank determination and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 29.43 mg of C14H18N2O5. [NOTE—A blank titration exceeding 0.1 mL may be due to excessive water content and may cause loss of visual endpoint sensitivity.].

Specifications of Aspartame BP Ph Eur Grade:
C14H18N2O5 --- 294.3 --- 22839-47-0
Action and use: Sweetening agent.

(3S)-3-Amino-4-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid (methyl α-L-aspartyl-L-phenylalaninate).
Content: 98.0 per cent to 102.0 per cent (dried substance).

Appearance: White or almost white, slightly hygroscopic, crystalline powder.
Solubility: Sparingly soluble or slightly soluble in water and in ethanol (96 per cent), practically insoluble in hexane and in methylene chloride.

First identification: B
Second identification: A, C, D
A. Ultraviolet and visible absorption spectrophotometry.
B. Infrared absorption spectrophotometry.
C. Thin-layer chromatography.
D. Dissolve about 20 mg in 5 mL of methanol and add 1 mL of alkaline hydroxylamine solution. Heat on a water-bath for 15 min. Allow to cool and adjust to about pH 2 with dilute hydrochloric acid. Add 0.1 mL of ferric chloride solution. A brownish-red colour is produced.

Solution S: Dissolve 0.8 g in carbon dioxide-free water and dilute to 100 mL with the same solvent.
Appearance of solution: Solution S is clear and not more intensely coloured than reference solution.
Conductivity: Maximum 30 microS/cm. To pass the test.
Specific optical rotation: + 14.5 to + 16.5 (dried substance).
Related substances: To pass the test.
Loss on drying: Maximum 4.5 per cent, determined on 1.000 g by drying in an oven at 105C.
Sulfated ash: Maximum 0.2 per cent, determined on 1.0 g.

Dissolve 0.250 g in 1.5 mL of anhydrous formic acid and 60 mL of anhydrous acetic acid. Titrate immediately with 0.1 M perchloric acid, determining the end point potentiometrically.
1 mL of 0.1 M perchloric acid is equivalent to 29.43 mg of C14H18N2O5.

In an airtight container.

Specifications of Aspartame FCC Food Grade:
N-L-alpha-Aspartyl-L -phenylalanine 1-Methyl Ester; APM
C14H18N2O5 Formula weight 294.31
INS: 951 CAS: [22839-47-0]

Aspartame occurs as a white, crystalline powder. It is sparingly soluble in water and slightly soluble in alcohol. The pH of a 0.8% solution is between about 4.5 and 6.0.
Function: Sweetener; sugar substitute; flavor enhancer.

Identification: The infrared absorption spectrum of a potassium bromide dispersion of sample exhibits maxima only at the same wavelengths as those of a similar preparation of USP Aspartame Reference Standard.
Assay: Not less than 98% and not more than 102% of C14H18N2O5, calculated on the dried basis.
5-Benzyl-3,6-dioxo-2-piperazineacetic Acid: Not more than 1.5%.
Lead: Not more than 1 mg/kg.
Loss on Drying: Not more than 4.5%.
Optical (Specific) Rotation [alpha]D20°: Between +14.5° and +16.5°, calculated on the dried basis.
Other Related Substances: Not more than 2.0%.
Residue on Ignition: Not more than 0.2%.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

We also manufacture and supply as under:

L-Asparagine Monohydrate or (S)-(+)-2-Aminosuccinamic acid

Aspartame Acesulfame

Acesulfame Potassium


Calcium Saccharin

Collagen Peptide



Sodium Saccharin




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Last 6 April, 2024

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Aspartame or Asp-Phe methyl ester SDS Sheet, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 02-Oct-20

1. Product Identification

Product Name & Other Names: Aspartame or Asp-Phe methyl ester.
CAS No.: 22839-47-0
EINECS EC Code: 245-261-3
Molecular Weight: 294.31
Chemical Formula: C14H18N2O5
Relevant uses and uses advised against (if any): Industrial Manufacturing.
SUPPLIER: As per letterhead.

2. Hazards Identification

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Labeling according to GHS & Regulation (EC) No 1272/2008

GHS Label Elements

Signal Words: None

Hazards not otherwise classified (HNOC):
May cause mild skin irritation.
May cause mild eye irritation.
May cause mild respiratory irritation.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352 - IF ON SKIN: Wash with plenty of soap and water.
P303+P361+P353 - IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

3. Composition/Information on Ingredients

Product Name & Other Names: Aspartame or Asp-Phe methyl ester.
CAS No.: 22839-47-0
EINECS EC Code: 245-261-3

4. First Aid Measures

Always seek medical advice after the first aid treatment.
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Contact medical center quickly. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Get medical attention.

5. Fire Fighting Measures

Combustible at high temperature. High heat or direct flame is necessary to cause ignition. Toxic fumes, carbon monoxide and nitrogen oxides may be formed in fire.
Explosion: At high temperature, explosive vapor-air mixtures may be formed.
Fire Extinguishing Media: Dry chemical, foam, water spray or carbon dioxide. Do not use a solid stream of water, since the stream will scatter and spread the fire. Water spray may be used to keep fire exposed containers cool.
Special Information In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode.

6. Accidental Release Measures

Personal precautions, protective equipment and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil or water sources.
Methods and materials used for containment Cleanup procedures and Storage:
Small Spill: Mop and pick up the material and place in an appropriate waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill: Avoid dust formation. Keep away from heat. Keep away from sources of ignition. Provide ventilation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container.

7. Handling and Storage

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat or smoke while handling. Avoid contact with skin, eyes and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Keep away from heat and source of fire. Store in cold, dry and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not breathe dust. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing material.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits: The product does not contain any relevant quantities of materials with critical values that have to be monitored at the workplace.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to the substance is apparent and engineering controls are not feasible, consult an industrial hygienist. For emergencies, or instances where the exposure levels are not known, use a full-face piece positive-pressure, air-supplied respirator. WARNING: Air purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

9. Physical and Chemical Properties

Appearance: White solid.
Odor: Odorless.
Odor threshold: Not available.
pH: Not available.
Melting point: 246C - 247C
Boiling point: Decomposes.
Relative density: 1.35
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Sparingly soluble; Slightly soluble in ethanol.
Viscosity: Not available.
Molecular Weight: 294.31
Chemical Formula: C14H18N2O5.

10. Stability and Reactivity

Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, nitrogen oxides and toxic fumes may form when heated to decomposition.
Hazardous Polymerization: Not reported. However, it can explode under certain conditions.
Incompatibilities: Oxidizing agents, heat and sparks.
Conditions to Avoid: Heat, flames, sunlight, ignition sources and incompatibles.

11. Toxicological Information

Oral rat LD50: > 10.000 mg/kg.
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as possible or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Teratogenic Effects: Not available.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.

12. Ecological Information

Toxicity to fish: No information available.
Mobility: Likely to be mobile.
Biodegradability: Readily biodegradable
Results of PBT and vPvB assessment
: No data available for assessment.

13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.

14. Transport Information

DOT USA & ADR/RID Europe: Not regulated
IMDG: Not regulated
IATA: Not regulated

15. Regulatory Information

SARA 302
: Not subject to the reporting requirements of SARA Title III, Section 302.
SARA 313: This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards: No.
California Prop. 65 Components: This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.

16. Other Information

Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.