Low Substituted Hydroxypropyl Cellulose Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Low Substituted Hydroxypropyl Cellulose, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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Low Substituted Hydroxypropyl Cellulose: CAS Number: 9004-64-2, EINECS EC Number: 618-388-0, Molecular Formula: yy, Molecular Weight: yy, HS Code ---**

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Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Low Substituted Hydroxypropyl Cellulose.

For SDS MSDS Sheet Click
SDS MSDS Sheet of Low Substituted Hydroxypropyl Cellulose Manufacturers

Low Substituted Hydroxypropyl Cellulose
Pure Suppliers
Low Substituted Hydroxypropyl Cellulose

Low-Substituted Hydroxypropyl Cellulose USP NF Grade:

Low-Substituted Hydroxypropyl Cellulose is a low-substituted hydroxypropyl ether of cellulose. When dried at 105C for 1 h, it contains NLT 5.0% and NMT 16.0% of hydroxypropoxy groups (– OCH2CHOHCH3 ).

Sample: 20 mg
Analysis: Shake the Sample with 2 mL of water, and cautiously add 1 mL of a solution of anthrone in sulfuric acid (350 µg/mL).
Acceptance criteria: A blue to greenish-blue color develops at the zone of contact.
Sample: 0.1 g
Analysis: Shake the Sample thoroughly with 10 mL of water. Add 1 g of sodium hydroxide and shake until it becomes homogeneous. Save 5 mL of this solution for Identification test C. To 0.1 mL of this solution add 9 mL of 32 N sulfuric acid, and shake. Heat in a water bath for 3 min, accurately timed, and immediately cool in an ice bath. While the mixture is cold, carefully add 0.6 mL of ninhydrin TS. Allow to stand at room temperature.
Acceptance criteria: The red color that appears immediately turns to violet within 100 min.
Sample solution: 5 mL of the solution prepared for Identification test B
Analysis: Shake the Sample solution with 10 mL of a mixture of acetone and methanol (4:1).
Acceptance criteria: A white, flocculent precipitate is formed.

To pass the test by chromatography.
Acceptance criteria: 5.0%–16.0% of hydroxypropoxy groups (– OCH2CHOHCH3 ) on the dried basis

Residue on Ignition: NMT 0.5%
Chloride and Sulfate, Chloride:
Sample solution: Shake 0.50 g of Low-Substituted Hydroxypropyl Cellulose thoroughly with 30 mL of boiling water, heat on a water bath for 10 min, and filter the supernatant by decantation while hot. Wash the residue thoroughly with 50 mL of boiling water, combine the washings with the filtrate, and add water to make 100 mL after cooling.
Control solution: 0.25 mL of 0.02 N hydrochloric acid
Analysis: Using 10 mL of the Sample solution and the Control solution, proceed as directed in the chapter, starting with the addition of the nitric acid.
Acceptance criteria: NMT 0.36%; the Sample shows no more chloride than the Control solution.
Loss on Drying:
Analysis: Dry at 105C for 1 h.
Acceptance criteria: NMT 5.0%
Packaging and Storage: Preserve in tight containers.

Specifications of Low-substituted Hydroxypropylcellulose BP Ph Eur Grade:
Action and use: Excipient.

Low-substituted O-(2-hydroxypropylated) cellulose.
Content: 5.0 per cent to 16.0 per cent of hydroxypropoxy groups (dried substance).

Appearance: White or yellowish-white, hygroscopic powder or granules.
Solubility: Practically insoluble in ethanol (96 per cent). It dissolves in a dilute solution of sodium hydroxide producing a viscous solution. It swells in water, in a 106 g/L solution of sodium carbonate and in a 206 g/L solution of hydrochloric acid.

A. Infrared absorption spectrophotometry.
Comparison low-substituted hydroxypropylcellulose CRS.
B. Shake thoroughly 0.1 g with 10 mL of water. It does not dissolve.
C. To the suspension obtained in Identification B add 1 g of sodium hydroxide and shake until it becomes homogeneous. Transfer 5 mL of the solution to a suitable container, add 10 mL of a mixture of 1 volume of methanol and 4 volumes of acetone and shake; a white, flocculent precipitate is formed.

pH: 5.0 to 7.5.
Evenly distribute 1.0 g onto the surface of 100 mL of carbon dioxide-free water and stir using a magnetic stirrer.
Loss on drying: Maximum 5.0 per cent, determined on 1.000 g by drying in an oven at 105C for 1 h.
Sulfated ash: Not more than 0.8 per cent, determined on 1.0 g.

In an airtight container.

Specifications of Hydroxypropyl Cellulose FCC Food Grade:
Modified Cellulose
INS: 463 CAS: [9004-64-2]

Hydroxypropyl Cellulose occurs as a white powder. It is a cellulose ether containing hydroxypropyl substitution. It may contain a suitable anticaking agent. It is soluble in water and in certain organic solvents.
Function: Emulsifier; film coating; protective colloid; stabilizer; suspending agent; thickener.

A. Shake a 0.1% solution of sample. A layer of foam appears (distinction from cellulose gum).
B. Add 5 mL of a 5.0% solution of copper sulfate (or aluminum sulfate) to 5 mL of a 0.5% solution of sample. No precipitate forms (distinction from cellulose gum).
Assay: Not more than 80.5% of hydroxypropoxyl groups (⎯OCH2CHOHCH3) after drying, equivalent to not more than 4.6 hydroxypropyl groups per anhydroglucose unit.
Lead: Not more than 3 mg/kg.
Loss on Drying: Not more than 5.0%.
pH of a 1% Solution: Between 5.0 and 8.0.
Residue on Ignition: Not more than 0.5%.
Viscosity of a 10% Solution: Not less than 145 centipoises.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

We manufacture and supply as under:

Agar or China grass


Cellulose Acetate

Hydroxypropyl Chitosan

Hydroxypropyl Methylcellulose HPMC

Hydroxypropyl Methycellulose Phthalate

Hydroxypropyl Pea, Corn, Potato Starch

Hypromellose Acetate Succinate

Low Substituted Hydroxypropyl Cellulose

Microcrystalline Cellulose

Silicified Microcrystalline Cellulose.


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Last 30 April, 2024

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Low Substituted Hydroxypropyl Cellulose SDS GHS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet

Section 1: Chemical Product and Company Identification

Product Name & Other Names: Low Substituted Hydroxypropyl Cellulose.
CAS Number: 9004-64-2
EINECS EC Code: 618-388-0
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.

Section 2: Hazards Identification

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Hazard Class and Category Code(s), Regulation (EC) No 1272/2008 (CLP)

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Labeling Regulation as per GHS & EC 1272/2008 (CLP) & GHS

GHS Label Elements

Signal Word: None

Hazards not otherwise classified (HNOC):
May causes mild skin irritation.
May causes mild eye irritation.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352 - IF ON SKIN: Wash with plenty of soap and water.
P303+P361+P353 - IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

Section 3: Composition and Information on Ingredients

Product Name & Other Names: Low Substituted Hydroxypropyl Cellulose.
CAS Number: 9004-64-2
EINECS EC Code: 618-388-0

Section 4: First Aid Measures

Always seek medical advice after the first aid treatment.

Skin: Rinse with water. Soap may be used. Seek Medical Aid.
Eyes: Wash eyes with plenty of water for at least 15 minutes, lifting lids occasionally. Seek Medical Aid.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Ingestion: If swallowed, induce vomiting immediately after giving two glasses of water. Never give anything by mouth to an unconscious person.

Section 5: Fire and Explosion Data

Products of Combustion: Oxides of Carbon.
Fire Fighting Media and Instructions: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Section 6: Accidental Release Measures

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Ensure adequate ventilation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil or water sources.
Methods and materials used for containment Cleanup procedures and Storage:
Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to legal requirements.
Large Spill: Contain spilled material. Do not inhale vapors, mist, or gas. Avoid dust formation. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.

Section 7: Handling and Storage

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing agents.

Section 8: Exposure Controls/Personal Protection

Exposure Guidelines: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume, or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Section 9: Physical and Chemical Properties

Physical state and appearance: White or yellowish-white, hygroscopic powder or granules.
Odor: Odorless.
Odor threshold: Not available.
pH: 5 to 7.5.
Relative density: around 0.5
Melting point/freezing point: Not available.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Practically insoluble in ethanol (96 per cent). It dissolves in a dilute solution of sodium hydroxide producing a viscous solution. It swells in water, in a 106 g/L solution of sodium carbonate and in a 206 g/L solution of hydrochloric acid.

Section 10: Stability and Reactivity Data

Stability: It is stable in room temperature in closed containers under normal storage & handling.
Conditions of instability: Incompatible materials, Strong oxidizers. May react vigorously with bleaching powder, Fluorine, Nitric acid.
Incompatibility with various substances: Avoid high temperatures, sparks, open flames, and moisture. Avoid contact with strong oxidizing agents.
Polymerization: Will not occur.

Section 11: Toxicological Information

LD50 Oral - Rat: > 10000 mg/kg.
Carcinogenic Effects: Not a reported carcinogen by IARC, NTP, ACGIH, OSHA.
Reproductive toxicity: No data available.
Teratogenicity: No data available.
Developmental Effects: No data available.
The toxicological properties have not been fully investigated.

Section 12: Ecological Information

Toxicity to fish: No data available.
BOD5 and COD: Not available.
Persistence and Degradability: Not available.
Bioaccumulation/ Accumulation: Not available.
Mobility: Not available.

Section 13: Disposal Considerations

Waste Disposal: Waste must be disposed of in accordance with federal, state, and local environmental control regulations.

Section 14: Transport Information

DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods
IMDG/IMO: Not dangerous goods
IATA: Not dangerous goods

Section 15: Other Regulatory Information

USA Regulations:
SARA 313: Not applicable
SARA 311/312 Hazard Categories: Not applicable as per section 2.
California Prop 65: California No Significant Risk Level: None of the chemicals in this product are listed.

Section 16 - Additional Information

Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.