Silicified Microcrystalline Cellulose or Compound of Microcrystalline Cellulose and Colloidal Silicon Dioxide Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Silicified Microcrystalline Cellulose, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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Silicified Microcrystalline Cellulose or Compound of Microcrystalline Cellulose and Colloidal Silicon Dioxide: CAS Number: yy, EINECS EC Number: yy, Molecular Formula: yy, Molecular Weight: yy, HS Code ---**

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Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Silicified Microcrystalline Cellulose or Compound of Microcrystalline Cellulose and Colloidal Silicon Dioxide.

For SDS MSDS Sheet Click
SDS MSDS Sheet of Silicified Microcrystalline Cellulose or Compound of Microcrystalline Cellulose and Colloidal Silicon Dioxide Manufacturers

Silicified Microcrystalline Cellulose
Compound of Microcrystalline Cellulose and Colloidal Silicon Dioxide Pure Suppliers
Silicified Microcrystalline Cellulose

Silicified Microcrystalline Cellulose or Compound of Microcrystalline Cellulose and Colloidal Silicon Dioxide is the mixture of microcrystalline cellulose and colloidal silicon dioxide.

Specifications of Silicified Microcrystalline Cellulose USP NF Grade:

Silicified Microcrystalline Cellulose is composed of intimately associated microcrystalline cellulose and colloidal silicon dioxide particles, derived from aqueous coprocessing prior to drying the material during manufacture. The microcrystalline cellulose component is purified, partially depolymerized cellulose, prepared by treating alpha cellulose, obtained as a pulp from fibrous plant material, with mineral acids. The colloidal silicon dioxide is a submicroscopic fumed silica prepared by the vapor-phase hydrolysis of a silicon compound. The Residue on Ignition result indicates the percentage of colloidal silicon dioxide; the remainder is microcrystalline cellulose.

Infrared Absorption
Sample: 10 mg
Iodinated zinc chloride solution: Dissolve 20 g of zinc chloride and 6.5 g of potassium iodide in 10.5 mL of water. Add 0.5 g of iodine and shake for 15 min.
Analysis: Place the Sample on a watch glass and disperse in 2 mL of Iodinated zinc chloride solution.
Acceptance criteria: The substance takes on a violet-blue color.
Sample: 5 mg of residue from the test for Residue on Ignition
Analysis: Transfer the Sample to a platinum crucible, and mix with about 200 mg of anhydrous potassium carbonate. Ignite at a red heat over a burner for about 10 min, and cool. Dissolve the melt in 2 mL of freshly distilled water, warming if necessary, and slowly add 2 mL of ammonium molybdate to the solution.
Acceptance criteria: A deep yellow color is produced.
D. Silica Dispersion Uniformity Test: To pass the test.

Residue on Ignition: 1.8%–2.2%
Microbial Enumeration Tests and Tests for Specified Microorganisms: The total aerobic microbial count does not exceed 1000 cfu/g, and the total combined molds and yeasts count does not exceed 100 cfu/g.
Sample: 5 g
Analysis: Shake the Sample with 40 mL of water for 20 min, and centrifuge. Retain the supernatant for use in the pH test. Using an appropriate conductivity meter that has been standardized with a potassium chloride conductivity calibration standard having a conductivity of 100 µS/cm, measure the conductivity of the supernatant after a stable reading is obtained, and measure the conductivity of the water used to prepare the test specimen.
Acceptance criteria: The conductivity of the supernatant does not exceed the conductivity of the water by more than 75 microS/cm.
pH: 5.0–7.5 for the supernatant obtained in the Conductivity test
Loss on Drying:
Analysis: Dry at 105C for 3 h.
Acceptance criteria: NMT 7.0%, within a percentage range, as specified in Labeling
Degree of Polymerization:
To pass the test
Acceptance criteria: NMT 350
Bulk Density:
Sample: Silicified Microcrystalline Cellulose powder
Analysis: Use a volumeter that has been fitted with a 10-mesh screen. The volumeter is freestanding of the brass or stainless steel cup, which is calibrated to a capacity of 25.0 ± 0.05 mL and has an inside diameter of 30.0 ± 2.0 mm. Weigh the empty cup, position it under the chute, and slowly pour the powder from a height of 5.1 cm (2 inches) above the funnel through the volumeter, at a rate suitable to prevent clogging, until the cup overflows. [Note— If excessive clogging of the screen occurs, remove the screen.] Level the excess powder, and weigh the filled cup. Calculate the bulk density by dividing the weight of the powder in the cup by the volume of the cup.
Acceptance criteria: Within the labeled specification
Particle Size Distribution: Where the labeling states the particle size distribution, determine the particle size distribution as directed in a suitable validated procedure.
Water-Soluble Substances:
Sample: 5.0 g
Analysis: Shake the Sample with 80 mL of water for 10 min, and filter with the aid of vacuum through filter paper (Whatman No. 42 or equivalent) into a vacuum flask. Transfer the filtrate to a tared beaker, evaporate to dryness without charring, dry at 105° for 1 h, cool in a desiccator, and weigh.
Acceptance criteria: NMT 0.25%; the difference between the weight of the residue and the weight obtained from a blank determination is NMT 12.5 mg.
Ether-Soluble Substances:
Sample: 10.0 g
Analysis: Place the Sample in a chromatographic column having an internal diameter of about 20 mm and pass 50 mL of peroxide-free ether through the column. Evaporate the eluate to dryness in a previously dried and tared evaporating dish with the aid of a current of air in a fume hood. After all the ether has evaporated, dry the residue at 105° for 30 min, cool in a desiccator, and weigh.
Acceptance criteria: NMT 0.05%; the difference between the weight of the residue and the weight obtained from a blank determination is NMT 5.0 mg.
Packaging and Storage: Preserve in tight containers. No storage requirements specified.
Labeling: Label it to indicate the nominal Loss on Drying, Bulk Density, and Degree of Polymerization values. Where the particle size distribution is stated in the labeling, proceed as directed in Particle Size Distribution. The labeling indicates the technique with which the particle size distribution was determined, if a technique other than analytical sieving was used. The labeling also indicates the d 10 , d 50 , and d 90 values and the range for each.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

We manufacture and supply as under:

Fumed Silica & Precipitated Silica

Mesoporous Silica Nanoparticles

Silicified Microcrystalline Cellulose.

Microcrystalline Cellulose

Microcrystalline cellulose and Calcium phosphate dibasic

Microcrystalline cellulose and Calcium carbonate


Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +912223770100, +912223726950
Current Date Time in India GMT+5:30


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neighbouring buyers may
Call toll-free 1-877-682-9243 (1-877-MUBYCHEM)

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Last 14 May, 2024

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Silicified Microcrystalline Cellulose SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet

Section 1: Chemical Product and Company Identification

Product Name & Other Names: Silicified Microcrystalline Cellulose.
CAS Number: Mixture
EINECS EC Code: Mixture
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.

Section 2: Hazards Identification

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Hazard Class and Category Code(s), Regulation (EC) No 1272/2008 (CLP)

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Labeling Regulation EC 1272/2008 (CLP) & GHS

GHS Label Elements

Signal Word: None

Hazards not otherwise classified (HNOC):
May causes mild skin irritation.
May causes mild eye irritation.
May cause mild respiratory irritation.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

Section 3: Composition and Information on Ingredients

Product Name & Other Names: Silicified Microcrystalline Cellulose.
Composition Item 1:
Item Name:
Microcrystalline Cellulose
CAS Number
: 9004-34-6
EINECS EC Code: 232-674-9
Composition Item 2:
Item Name:
Colloidal Silicon Dioxide
CAS Number
: 112945-52-5
EINECS EC Code: 231-545-4
Details of no components need to be disclosed according to the applicable regulations.

Section 4: First Aid Measures

Always seek medical advice after the first aid treatment.

Skin: Rinse with water. Soap may be used. Seek Medical Aid.
Eyes: Wash eyes with plenty of water for at least 15 minutes, lifting lids occasionally. Seek Medical Aid.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Ingestion: If swallowed, induce vomiting immediately after giving two glasses of water. Never give anything by mouth to an unconscious person.

Section 5: Fire and Explosion Data

Flammability of the Product: Non-flammable.
Products of Combustion: Oxides of Carbon.
Fire Fighting Media and Instructions: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Section 6: Accidental Release Measures

Personal precautions, protective equipment and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Ensure adequate ventilation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil or water sources.
Methods and materials used for containment Cleanup procedures and Storage:
Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to legal requirements.
Large Spill: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container. Do not inhale vapors, mist, or gas. Avoid dust formation. Finish cleaning by spreading water on the contaminated surface and allow as per law.

Section 7: Handling and Storage

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat or smoke while handling. Avoid contact with skin, eyes and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing agents, acids.

Section 8: Exposure Controls/Personal Protection

Exposure Limits:
For Silicon Dioxide: USA OSHA PEL: 6 mg/m3
Silicified Microcrystalline Cellulose: UK 10mg/m3.
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants low.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Section 9: Physical and Chemical Properties

Physical state and appearance: White or almost white, fine, slightly hygroscopic powder.
Odor: Odorless.
Odor threshold: Not available.
pH (5% soln/water): Not available.
Relative density: Not available.
Melting point/freezing point: Not available.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Practically insoluble in water.
Viscosity: Not available.

Section 10: Stability and Reactivity Data

Stability: It is stable in room temperature in closed containers under normal storage & handling.
Conditions of instability: Incompatible materials, Moisture
Incompatibility with various substances: Avoid high temperatures, sparks, open flames and moisture. Avoid contact with strong oxidizing agents.
Polymerization: Will not occur.

Section 11: Toxicological Information

Toxicity Data: Not available.
Carcinogenic Effects: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC, NTP, ACGIH, OSHA.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.

Section 12: Ecological Information

Toxicity to fish: Not available.
BOD5 and COD: Not available.
Products of Biodegradation: The product itself and its products of degradation are not toxic.
Persistence and Degradability: It is degradable to a large extent.
Mobility: Not available.
Bioaccumulation/ Accumulation: Not available.
Results of PBT and vPvB assessment: No data available for assessment.

Section 13: Disposal Considerations

Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations.

Section 14: Transport Information

DOT (USA): Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
ADR/RID: Not dangerous goods

Section 15: Other Regulatory Information

USA Regulations:
OSHA: None of the chemicals in this product are considered highly hazardous by OSHA.
California Prop 65: California No Significant Risk Level: None of the chemicals in this product are listed.

Section 16 - Additional Information

Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.