Hydroxypropyl Methyl Cellulose Acetate Succinate or Hypromellose Acetate Succinate USP NF Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Hydroxypropyl Methyl Cellulose Acetate Succinate or Hypromellose Acetate Succinate USP NF Grade, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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Hydroxypropyl Methyl Cellulose Acetate Succinate or Hypromellose Acetate Succinate: CAS Number: 71138-97-1, EINECS EC Number: 615-255-9, Molecular Formula: C10H22O9, Molecular Weight: 286.28, HS Code ---**

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Hydroxypropyl Methyl Cellulose Acetate Succinate or Hypromellose Acetate Succinate.

Specifications of Hypromellose Acetate Succinate USP NF Grade:
Hydroxypropyl methylcellulose acetate succinate;
Cellulose, 2-hydroxypropyl methyl ether, acetate hydrogen butanedioate;
Cellulose, 2-hydroxypropyl methyl ether, acetate succinate --- CAS 71138-97-1

DEFINITION
Hypromellose Acetate Succinate is a mixture of acetic acid and monosuccinic acid esters of hydroxypropyl methylcellulose. It contains NLT 12.0% and NMT 28.0% of methoxy groups (– OCH3), NLT 4.0% and NMT 23.0% of hydroxypropoxy groups (– OCH2CHOHCH3), NLT 2.0% and NMT 16.0% of acetyl groups (– COCH3 ), and NLT 4.0% and NMT 28.0% of succinoyl groups (– COC2H4COOH), calculated on the dried basis.

IDENTIFICATION
A. Infrared Absorption:
To pass the test.
Acceptance criteria: The IR spectrum of the Sample exhibits maxima only at the same wavelengths as a similarly obtained spectrum of USP Hypromellose Acetate Succinate.
ASSAY
Acetyl and Succinoyl Groups:
To pass the test by Chromatography
Acceptance criteria:
Acetyl groups (– COCH3 ): 2.0%–16.0% on the dried basis
Succinoyl groups (– COC2H4COOH): 4.0%–28.0% on the dried basis
Content of Methoxy and 2-Hydroxypropoxy Groups:
To pass the test by Chromatography
Acceptance criteria
Methoxy groups (– OCH3 ): 12.0%–28.0% on the dried basis
Hydroxypropoxy groups (– OCH2CHOHCH3): 4.0%–23.0% on the dried basis

Residue on Ignition:
Analysis: Determine at 600 ± 50C.
Acceptance criteria: NMT 0.20%
Limit of Free Acetic and Succinic Acids:
To pass the test.
Acceptance criteria: The sum of free acetic acid and free succinic acid is NMT 1.0%.
Loss on Drying:
Analysis: Dry at 105C for 1 h.
Acceptance criteria: NMT 5.0%
Viscosity—Capillary Methods:
To pass the test.
Acceptance criteria: 80%–120% of that stated on the label
Packaging and Storage: Preserve in tight containers. No storage requirements specified.
Labeling: Label it to indicate its nominal viscosity type.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +912223770100, +912223726950
Current Date Time in India GMT+5:30

USA, Canada, Mexico and other American
neighbouring buyers may
e-mail: us@mubychem.com
Call toll-free 1-877-682-9243 (1-877-MUBYCHEM)

Exporters to USA Canada UAE Europe South Africa Tanzania Kenya Uganda Egypt Nigeria Turkey Mexico Brazil Argentina Chile Dubai etc.

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Hypromellose Acetate Succinate SDS GHS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 23-Oct-20

Product Name & Other Names: Hypromellose Acetate Succinate.
CAS Number: 71138-97-1
EINECS EC Code: 615-255-9
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Hazard Class and Category Code(s), Regulation (EC) No 1272/2008 (CLP)

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Hazards not otherwise classified (HNOC):
May causes mild skin irritation.
May causes mild eye irritation.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

Product Name & Other Names: Hypromellose Acetate Succinate.
CAS Number: 71138-97-1
EINECS EC Code: 615-255-9

Always seek medical advice after the first aid treatment.
Skin: Rinse with water. Soap may be used. Seek Medical Aid.
Eyes: Wash eyes with plenty of water for at least 15 minutes, lifting lids occasionally. Seek Medical Aid.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Ingestion: If swallowed, induce vomiting immediately after giving two glasses of water. Never give anything by mouth to an unconscious person.

Products of Combustion: Oxides of Carbon.
Fire Fighting Media and Instructions: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Ensure adequate ventilation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil or water sources.
Methods and materials used for containment Cleanup procedures and Storage:
Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to legal requirements.
Large Spill: Contain spilled material. Do not inhale vapors, mist, or gas. Avoid dust formation. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing agents, acids.

Exposure Guidelines: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume, or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Physical state and appearance: White to light-yellow powder.
Odor: Odorless.
Odor threshold: Not available.
pH: 5 to 8.
Relative density: Not available.
Melting point/freezing point: Not available.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Practically insoluble in water. Soluble in methanol.
Viscosity: As per label.

Stability: It is stable in room temperature in closed containers under normal storage & handling.
Conditions of instability: Incompatible materials, Strong oxidizers. May react vigorously with bleaching powder, Fluorine, Nitric acid.
Incompatibility with various substances: Avoid high temperatures, sparks, open flames, and moisture. Avoid contact with strong oxidizing agents.
Polymerization: Will not occur.

LD50 Oral - Rat: No data available.
Carcinogenic Effects: Not a reported carcinogen by IARC, NTP, ACGIH, OSHA.
Reproductive toxicity: No data available.
Teratogenicity: No data available.
Developmental Effects: No data available.
The toxicological properties have not been fully investigated.

Toxicity to fish: No data available.
BOD5 and COD: Not available.
Persistence and Degradability: Soluble in water and hence may not persist.
Bioaccumulation/ Accumulation: No information available.
Mobility: Is likely mobile in the environment due its water solubility.

Waste Disposal: Waste must be disposed of in accordance with federal, state, and local environmental control regulations.

DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods.

USA Regulations:
SARA 313: Not applicable
SARA 311/312 Hazard Categories: Not applicable. See section 2.
California Prop 65: California No Significant Risk Level: None of the chemicals in this product are listed.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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