Hydroxypropyl Methycellulose Phthalate or Hydroxypropyl methyl cellulose phthalate or HPMC-P or Hypromellose Phthalate USP NF BP Ph Eur Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Hydroxypropyl Methycellulose Phthalate or Hypromellose Phthalate USP NF BP Ph Eur, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

The products are offered as per required specifications and in correct shape and size in mm or meshs or microns as specified by the buyer.

The participating units have one or more accreditations like FDA - cGMP and GLP approval, ISO-9001 Certified, "REACH" Registered, ISO-14001, ISO/IEC 17025, ISO-22000, FSSC 22000, ISO 45001, Kosher Certified, Halal Certified, HACCP, FSSAI. We offer Commercial Pure & IP BP EP Ph Eur USP NF JP FCC Food Grade Analytical Reagent Grades of Chemicals

Bookmark this Web Site -- or -- Email This Page Info to a Colleague or Yourself

Search our website here:

---------

Export to USA UAE Europe Africa Tanzania Kenya Egypt Turkey Jumbo Packing; Exports to USA UAE Europe Africa Tanzania Kenya Uganda Egypt Turkey Brazil Chile Argentina Dubai etc. Packing Palletized and Shrink Wrapped; 25kg or 50kg or 55 lbs HDPE laminated bags with an extra HMHDP liner Drum Packing for better transportation Drum Packing & Palletized Liquid Chemical Export Import Air Freighting

Hydroxypropyl Methycellulose Phthalate or Hydroxypropyl methyl cellulose phthalate or HPMC-P or Hypromellose Phthalate: CAS Number: 9050-31-1, EINECS EC Number: 232-674-9 or 618-567-3, Molecular Formula: yy, Molecular Weight: yy, HS Code ---**

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Hydroxypropyl Methycellulose Phthalate or Hydroxypropyl methyl cellulose phthalate or HPMC-P or Hypromellose Phthalate USP NF BP Ph Eur.

Hydroxypropyl Methy Cellulose Phthalate or HPMC-P or Hydroxypropyl Methycellulose Phthalate or Hypromellose Phthalate is white or off-white granular solid which is tasteless and used as enteric sugar-coating material with excellent gastric acid resistance, insoluble at pH PH=5.0-5.5. It’s mainly used in tablets, granules etc. and also widely used in aquaculture, biotechnology and other industries. In the pharmaceutical industry, hypromellose phthalate is used as a coating agent for tablets and granules. It is a colorless, odorless, white powder.

DEFINITION
Hypromellose Phthalate is a monophthalic acid ester of hydroxypropyl methylcellulose. It contains methoxy (-OCH3 ), hydroxypropoxy (-OCH2CHOHCH3 ), and phthalyl (o-carboxybenzoyl, C8H5O3 ) groups. It contains NLT 21.0% and NMT 35.0% of phthalyl groups, calculated on the anhydrous basis.

IDENTIFICATION
A. Infrared Absorption: Do not dry specimens.
Phthalyl Content: To pass the test.
Acceptance criteria: 21.0%–35.0% of phthalyl groups on the anhydrous basis.
Residue on Ignition: NMT 0.20%
Chloride and Sulfate, Chloride:
Sample solution: Dissolve 1.0 g in 40 mL of 0.2 N sodium hydroxide, add 1 drop of phenolphthalein and add 2 N nitric acid dropwise, with stirring, until the red color is discharged. Add an additional 20 mL of 2 N nitric acid with stirring. Heat on a water bath, with stirring, until the gel-like precipitate formed becomes granular. Cool the mixture, and centrifuge. Separate the liquid phase and wash the residue with three successive 20-mL portions of water, separating the washings by centrifuging. Dilute the combined liquids with water to 200 mL, mix, and filter.
Standard solution: Treat 0.50 mL of 0.01 N hydrochloric acid with 10 mL of 0.2 N sodium hydroxide, add 7 mL of 2 N nitric acid, and dilute with water to 50 mL.
Acceptance criteria: A 50-mL portion of the Sample solution shows no more chloride than the Standard solution (0.07%).
Limit of Free Phthalic Acid:
Acceptance criteria: NMT 1.0%
Water Determination: NMT 5.0%
Viscosity-Capillary: To pass the test.
Acceptance criteria: 80%–120% of that indicated by the label.
Packaging and Storage: Preserve in tight containers.
Labeling: Label it to indicate its viscosity and nominal phthalyl content.

DEFINITION
Hydroxypropylmethylcellulose phthalate.
Monophthalic acid ester of hypromellose, containing methoxy (-OCH3), 2-hydroxypropoxy (-OCH2CHOHCH3) and phthaloyl (o-carboxybenzoyl C8H5O3) groups.

CHARACTERS
Appearance: White or almost white, free-flowing flakes or granular powder.
Solubility: Practically insoluble in water, soluble in a mixture of equal volumes of acetone and methanol and in a mixture of equal volumes of methanol and methylene chloride, very slightly soluble in acetone and in toluene, practically insoluble in anhydrous ethanol.

IDENTIFICATION
Infrared absorption spectrophotometry.
Preparation Dissolve 40 mg in 1 mL of a mixture of equal volumes of methanol and methylene chloride; spread 2 drops of this solution between 2 sodium chloride plates, then remove one of the plates to evaporate the solvent.
Comparison hypromellose phthalate CRS.

TESTS
Free phthalic acid: To pass the test.
Limit: — phthalic acid: not more than 0.4 times the area of the corresponding peak in the chromatogram obtained with the reference solution (1.0 per cent).
Chlorides: Maximum 0.07 per cent.
Water: Maximum 5.0 per cent, determined on 0.500 g.
Sulfated ash: Maximum 0.2 per cent, determined on 1.0 g.
Apparent viscosity: 80 per cent to 120 per cent of the nominal value.
Solubility: 0.2 g does not dissolve in 0.1 M hydrochloric acid but dissolves quickly and completely in 100 mL of phosphate buffer solution pH 6.8 with stirring.
Phthaloyl groups: Typically 21.0 per cent to 35.0 per cent (anhydrous substance).

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +912223770100, +912223726950
Current Date Time in India GMT+5:30

USA, Canada, Mexico and other American
neighbouring buyers may
e-mail: us@mubychem.com
Call toll-free 1-877-682-9243 (1-877-MUBYCHEM)

Exporters to USA Canada UAE Europe South Africa Tanzania Kenya Uganda Egypt Nigeria Turkey Mexico Brazil Argentina Chile Dubai etc.

Global or International Suppliers, Exporters, Importers, Manufacturers

I shall pass through this world, but once. If therefore, there is any good that I can do, or if there is any favor that I can show to a fellow human being, let me do it now. Let me not defer or neglect it. For I shall not tread this way again

Hydroxypropyl Methycellulose Phthalate or Hydroxypropyl methyl cellulose phthalate or HPMC-P or Hypromellose Phthalate SDS GHS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 23-Oct-20

Product Name & Other Names: Hydroxypropyl Methycellulose Phthalate or Hydroxypropyl methyl cellulose phthalate or HPMC-P or Hypromellose Phthalate.
CAS Number: 9050-31-1
EINECS EC Code: 232-674-9 or 618-567-3
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Hazard Class and Category Code(s), Regulation (EC) No 1272/2008 (CLP)

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Hazards not otherwise classified (HNOC):
May causes mild skin irritation.
May causes mild eye irritation.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

Skin: Rinse with water. Soap may be used. Seek Medical Aid.
Eyes: Wash eyes with plenty of water for at least 15 minutes, lifting lids occasionally. Seek Medical Aid.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Ingestion: If swallowed, induce vomiting immediately after giving two glasses of water. Never give anything by mouth to an unconscious person.

Products of Combustion: Oxides of Carbon.
Fire Fighting Media and Instructions: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes.

Personal precautions, protective equipment and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Ensure adequate ventilation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil or water sources.
Methods and materials used for containment Cleanup procedures and Storage:
Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to legal requirements.
Large Spill: Contain spilled material. Do not inhale vapors, mist, or gas. Avoid dust formation. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat or smoke while handling. Avoid contact with skin, eyes and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing agents, acids.

Exposure Guidelines: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Physical state and appearance: White or almost white, free-flowing flakes or granular powder.
Odor: Not available.
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Melting point/freezing point: Not available.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Practically insoluble in water, soluble in a mixture of equal volumes of acetone and methanol and in a mixture of equal volumes of methanol and methylene chloride, very slightly soluble in acetone and in toluene, practically insoluble in anhydrous ethanol.
Viscosity: As per label.

Stability: It is stable in room temperature in closed containers under normal storage & handling.
Conditions of instability: Incompatible materials, Strong oxidizers. May react vigorously with bleaching powder, Fluorine, Nitric acid.
Incompatibility with various substances: Avoid high temperatures, sparks, open flames and moisture. Avoid contact with strong oxidizing agents.
Polymerization: Will not occur.

LD50 Oral - Rat: No data available.
Carcinogenic Effects: Not a reported carcinogen by IARC, NTP, ACGIH, OSHA.
Reproductive toxicity: No data available.
Teratogenicity: No data available.
Developmental Effects: No data available.
The toxicological properties have not been fully investigated.

Toxicity to fish: No data available.
BOD and COD: Not available.
Persistence and Degradability: No information available.
Bioaccumulation/ Accumulation: No information available.
Mobility: No information available.

Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations.

DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
IMDG: Not dangerous goods.
IATA: Not dangerous goods.

USA Regulations:
SARA 313: Not applicable
SARA 311/312 Hazard Categories: Not applicable
California Prop 65: California No Significant Risk Level: None of the chemicals in this product are listed.

Disclaimer:
**************************
Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
**************************

List of All the IP, BP, EP, Ph Eur, USP NF, JP, FCC Food, Analytical Reagent Grades of Chemicals
Best Seller Fast Moving IP, BP, EP, Ph Eur, USP NF, JP, FCC Food, Analytical Reagent Grades of Chemicals Ex-stock Items
Aluminum Chloride Hexahydrate	Aluminium Potassium Sulphate
Ammonium Bicarbonate	Ammonium Carbonate
Ammonium Chloride	Ammonium Persulfate
Borax; Sodium Borate	Boric Acid
Calcium Chloride	Calcium Saccharate
Calcium Sulfate	Carbamide Peroxide
Chromic Chloride	Cupric or Copper Chloride
Ferric Chloride Hexahydrate	Fumaric Acid
Glacial Acetic Acid	Lactobionic Acid
Magnesium Chloride	Magnesium Sulfate
Manganese Chloride	Manganese Sulfate
Potassium Bromide	Potassium Chloride
Potassium Hydroxide Pellets	Potassium Nitrate
Propylene Carbonate	Potassium Monopersulfate
Selenious acid	Sodium Acetate
Sodium Bromate	Sodium Diacetate
Sodium Formaldehyde Bisulfite	Sodium Lactobionate
Sodium Thiosulfate	Zinc Chloride