Pyridoxine Hydrochloride or Vitamin B6 USP BP Ph Eur FCC Food Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Pyridoxine Hydrochloride or Vitamin B6, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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Pyridoxine Hydrochloride or Vitamin B6 CAS Number 58-56-0, EINECS EC Number: 200-386-2, Molecular Formula: C8H11NO3-HCl, Molecular Weight: 205.64, HS Code 29362500

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Pyridoxine Hydrochloride or Vitamin B6.

Pyridoxine is a form of vitamin B6 found commonly in food and used as a dietary supplement. As a supplement. Pyridoxine Hydrochloride is the hydrochloride salt form of pyridoxine, a water-soluble vitamin B.

General Properties and Specifications of Pyridoxine Hydrochloride or Vitamin B6:
Appearance: White to off-white crystalline powder.
Solubility of 5% aq. solution: Clear colorless to pale yellow.
Assay: 99% minimum.
Loss on drying: 0.5% maximum.
Sulfated Ash: 0.1% maximum.
Heavy Metals (Pb): 0.003% maximum.
pH: 2.3 - 3.5 for 5% aq. solution.
Melting Point: 205C to 212C (Decomposes) literature.
Absorbance (A) of 0.001% solution in 0.1N HCl in a 1cm cell @290nm: about ~ 0.436
Suitability for Cell Culture: Passes test.
Bacterial Endotoxin Test (BET) (EU/mg = IU/mg): <1.0 EU/mg.
Storage: 8C to 25C (Cool & dry area). Ok to freeze. Preserve in tight, light-resistant containers.

Pyridoxine Hydrochloride USP Grade Specifications:
C8H11NO3-HCl --- 205.64
3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride;
Pyridoxol hydrochloride CAS 58-56-0
UNII: 68Y4CF58BV
UNII: KV2JZ1BI6Z

DEFINITION
Pyridoxine Hydrochloride contains NLT 98.0% and NMT 102.0% of pyridoxine hydrochloride (C8H11NO3-HCl), calculated on the dried basis.

IDENTIFICATION
A. Infrared Absorption
B. Identification Tests—General, Chloride: Meets the requirements.

Residue on Ignition: NMT 0.1%
Content of Chloride: 16.9%–17.6% on the dried basis.
Loss on Drying: Dry a sample in vacuum over silica gel for 4 h: it loses NMT 0.5% of its weight.

Pyridoxine Hydrochloride BP Ph Eur Grade Specifications:
When vitamin B6 is prescribed or demanded, Pyridoxine Hydrochloride shall be dispensed or supplied.
C8H12ClNO3 --- 205.6 CAS 58-56-0
Action and use: Vitamin B6.

DEFINITION
(5-Hydroxy-6-methylpyridine-3,4-diyl)dimethanol hydrochloride.
Content: 99.0 per cent to 101.0 per cent (dried substance).

CHARACTERS
Appearance: White or almost white, crystalline powder.
Solubility: Freely soluble in water, slightly soluble in ethanol (96 per cent).
MP: About 205C, with decomposition.

IDENTIFICATION
First identification: B, D
Second identification: A, C, D
A. Ultraviolet and visible absorption spectrophotometry.
B. Infrared absorption spectrophotometry.
C. Thin-layer chromatography.

Solution S: Dissolve 2.50 g in carbon dioxide-free water and dilute to 50.0 mL with the same solvent.
Appearance of solution: Solution S is clear and not more intensely coloured than reference solution.
pH: 2.4 to 3.0 for solution S.
Related substances: To pass the test.
Loss on drying: Maximum 0.5 per cent, determined on 1.000 g by drying in an oven at 105C.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.

Pyridoxine Hydrochloride FCC Food Grade:
5-Hydroxy-6-methyl-3,4-pyridinedimethanol Hydrochloride;
Pyridoxol Hydrochloride; Vitamin B6 Hydrochloride; Vitamin B6

DESCRIPTION
Pyridoxine Hydrochloride occurs as colorless or white crystals or as a white, crystalline powder. It is stable in the air but is slowly affected by sunlight. Its solutions are acid to litmus, having a pH of about 3. One-gram dissolves in 5 mL of water and in about 100 mL of alcohol. It is insoluble in ether. It melts at about 206C with some decomposition.
Function: Nutrient.

REQUIREMENTS
Identification:
A. Place 1 mL of a solution containing about 100 _g of sample in each milliliter into each of two test tubes marked A and B and add 2 mL of a 1:5 sodium acetate solution to each tube. Add 1 mL of water to tube A and add 1 mL of a 1:25 boric acid solution to tube B, and mix. Cool both tubes to about 20°, and rapidly add 1 mL of a 1:200 solution of 2,6-dichloroquinonechlorimide in alcohol to each tube. A blue color appears in tube A, which fades rapidly and becomes red in a few minutes, but no blue color appears in tube B.
B. Add 0.5 mL of phosphotungstic acid to 2 mL of a 1:200 aqueous solution. A white precipitate forms.
C. A sample gives positive tests for Chloride, Appendix IIIA.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +912223770100, +912223726950
Current Date Time in India GMT+5:30

USA, Canada, Mexico and other American
neighbouring buyers may
e-mail: us@mubychem.com
Call toll-free 1-877-682-9243 (1-877-MUBYCHEM)

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Pyridoxine Hydrochloride or Vitamin B6 SDS Sheet, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 17-Dec-23

Product Name & Other Names: Pyridoxine Hydrochloride or Vitamin B6.
CAS No.: 58-56-0
EINECS EC Code: 200-386-2
Molecular Weight: 205.64
Chemical Formula: C8H11NO3-HCl
Relevant uses and uses advised against (if any): Industrial Manufacturing.
SUPPLIER: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Hazards not otherwise classified (HNOC):
May cause mild skin irritation.
May cause mild eye irritation.
May cause mild respiratory irritation.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

Product Name & Other Names: Pyridoxine Hydrochloride or Vitamin B6.
CAS No.: 58-56-0
EINECS EC Code: 200-386-2

Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Contact medical center quickly. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: Check for and remove any contact lenses. Immediately flush your eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Get medical attention.

Combustible at high temperature. High heat or direct flame is necessary to cause ignition. Toxic fumes, carbon monoxide, hydrogen chloride, and nitrogen oxides may be formed in fire.
Explosion: At high temperature, explosive vapor-air mixtures may be formed.
Fire Extinguishing Media: Dry chemical, foam, water spray or carbon dioxide. Do not use a solid stream of water since the stream will scatter and spread the fire. Water spray may be used to keep fire exposed containers cool.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and a suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: Mop and pick up the material and place in an appropriate waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill: Avoid dust formation. Keep away from heat. Keep away from sources of ignition. Provide ventilation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Keep away from heat and source of fire. Store in cold, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not breathe dust. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing material. Storage: 8C to 25C (Cool & dry area). Ok to freeze. Preserve in tight, light-resistant containers.

Airborne Exposure Limits: The product does not contain any relevant quantities of materials with critical values that have to be monitored at the workplace.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to the substance is apparent and engineering controls are not feasible, consult an industrial hygienist. For emergencies, or instances where the exposure levels are not known, use a full-face piece positive-pressure, air-supplied respirator. WARNING: Air purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron, or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or a full-face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: White to off-white crystalline powder.
Odor: Not available.
Odor threshold: Not available.
pH: 2.3 - 3.5 for 5% aq. solution.
Melting point: 205C to 212C (Decomposes) literature.
Boiling point: Not available.
Relative density: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Soluble in water.
Viscosity: Not available.
Molecular Weight: 205.64
Chemical Formula: C8H11NO3-HCl

Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, hydrogen chloride, nitrogen oxides, and toxic fumes may form when heated to decomposition.
Hazardous Polymerization: Not reported. However, it can explode under certain conditions.
Incompatibilities: Strong oxidizing agents, heat, and sparks.
Conditions to Avoid: Heat, flames, sunlight, ignition sources and incompatibles.

11. Toxicological Information
LD50 Oral - Rat - 4000 mg/kg.
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as possible or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Teratogenic Effects: Not available.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.

Toxicity to fish: static test LC50 - Oncorhynchus mykiss (rainbow trout) - > 100 mg/l - 96 h.
Toxicity to daphnia and other aquatic invertebrates: static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h.
Mobility & Persistence: Likely to be mobile and unlikely to persist due to water solubility.
Biodegradability: Expected to be biodegradable
Results of PBT and vPvB assessment: No data available for assessment.

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of containers and unused contents in accordance with federal, state, and local requirements.

DOT USA & ADR/RID Europe: Not regulated.
IMDG/IMO: Not regulated.
IATA/ICAO: Not regulated.

USA:
SARA 311/312 Hazards: See section 2.
California Prop. 65 Components: This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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