Vitamin K1 or Phytomenadione or Phytonadione BP Ph Eur USP FCC Food Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Vitamin K1 or Phytomenadione or Phytonadione BP Ph Eur USP FCC Food Grade, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy Portugal, Bangladesh, etc.

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Vitamin K1 or Phytomenadione or Phytonadione CAS Number 84-80-0 or 12001-79-5, EINECS EC Number: 201-564-2, Molecular Formula: C31H46O2, Molecular Weight: 450.7, HS Code 29362940

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Vitamin K1 or Phytomenadione or Phytonadione.

Vitamin K1 or 2-Methyl-3-phytyl-1,4-naphthoquinone Phylloquinone is an organic compound. It occurs as yellow fine powder. Vitamins K1 phytonadione is commonly available as a supplement. Vitamin K1, also called phylloquinone, is mostly found in plant foods like leafy green vegetables. Vitamin K is an essential vitamin needed by the body for blood clotting, bone building, and other important processes. Taking vitamin K2 and vitamin K1 by mouth seems to improve bone strength and reduce the risk of fractures in people with weak bones.

General Properties and Specifications of Vitamin K1 5%:
Appearance: Yellow fine powder.
Dispersibility: Disperse from homogenous mixture.
LOD: Not more than 5 %
Assay of Vitamin K1: Not less than 5.00 %

Phytonadione USP Grade Specifications:
C31H46O2 --- 450.70
1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, [R-[R*,R*-(E)]]-;
Phylloquinone CAS 84-80-0
UNII: A034SE7857
UNII: S5Z3U87QHF

DEFINITION
Phytonadione is a mixture of E- and Z-isomers containing NLT 97.0% and NMT 103.0% of phytonadione isomers (C31H46O2). It contains NMT 21.0% of the Z-isomer.

IDENTIFICATION
A. Infrared Absorption
B. Ultraviolet Absorption
Analytical wavelength: 248 nm
Sample solution: 10 µg/mL in n-hexane
Acceptance criteria: Meets the requirements. Absorptivities do not differ by more than 3.0%.

Limit of Menadione:
Sample: 20 mg of Phytonadione
Analysis: Mix the Sample with 0.5 mL of a mixture of 6 N ammonium hydroxide and alcohol (1:1). Add 1 drop of ethyl cyanoacetate and shake gently.
Acceptance criteria: No purple or blue color is produced.
Refractive Index: 1.523–1.526
Reaction: A 50-mg/mL solution of Phytonadione in dehydrated alcohol is neutral to litmus.
Packaging and Storage: Preserve in tight, light-resistant containers.

Phytomenadione BP Ph Eur Grade Specifications:
When vitamin K1 is prescribed or demanded, Phytomenadione shall be dispensed or supplied.
C31H46O2 --- 450.7
Action and use: Vitamin K analogue.

DEFINITION
Mixture of 2-methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione (trans-phytomenadione), 2-methyl-3-[(2Z,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione (cis-phytomenadione) and 2,3-epoxy-2-methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]-2,3-dihydronaphthalene-1,4-dione (trans-epoxyphytomenadione).
Content:
-- trans-epoxyphytomenadione: maximum 4.0 per cent;
-- trans-phytomenadione: minimum 75.0 per cent;
-- sum of trans-phytomenadione, cis-phytomenadione and trans-epoxyphytomenadione: 97.0 per cent to 103.0 per cent.

CHARACTERS
Appearance: Clear, intense yellow, viscous, oily liquid.
Solubility: Practically insoluble in water, sparingly soluble in ethanol (96 per cent), miscible with fatty oils. It decomposes on exposure to actinic light.
Refractive index: About 1.526.

IDENTIFICATION
Carry out all operations as rapidly as possible, avoiding exposure to actinic light.
A. Ultraviolet and visible absorptionspectrophotometry.
B. Examine the chromatograms obtained in the assay.
C. Dissolve 50 mg in 10 mL of methanol and add 1 mL of a 200 g/L solution of potassium hydroxide in methanol. A green colour is produced which becomes violet-red on heating in a water bath at 40C and then reddish-brown on standing.

Appearance of solution: The solution is clear.
Dissolve 2.5 g in trimethylpentane and dilute to 25 mL with the same solvent.
Acid value: Maximum 2.0, determined on 2.00 g.
Impurity A: To pass the test by Thin-layer chromatography. --- 0.2 per cent.
Related substances: To pass the test by Liquid chromatography.
Storage: Protected from light.

Vitamin K FCC Food Grade Specifications:
1,4-Naphthalenedione; 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl); Phylloquinone; Phytonadione.
C31H46O2 Formula weight 450.71
CAS 84-80-0

DESCRIPTION
Vitamin K occurs as a clear, yellow to amber, very viscous liquid. It has a specific gravity of about 0.967. It is stable in air but decomposes on exposure to sunlight. It is insoluble in water; soluble in dehydrated alcohol, in chloroform, in ether, and in vegetable oils; and slightly soluble in alcohol.
Function: Nutrient.

For Original Monographs of IP Indian Pharmacopoeia EP Ph Eur European Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

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Vitamin K1 or Phytomenadione or Phytonadione SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 01-Dec-24

Product Name & Other Names: Vitamin K1 or Phytomenadione or Phytonadione.
CAS Number: 84-80-0 or 12001-79-5
EINECS EC Code: 201-564-2
Molecular Formula: C31H46O2
Molecular Weight: 450.7
Relevant uses and uses advised against (if any): Industrial Manufacturing only.
Suppliers: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Hazard Class and Category Code(s), Regulation (EC) No 1272/2008 (CLP)

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Hazards not otherwise classified (HNOC):
May causes mild skin irritation.
May causes mild eye irritation.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a comfortable position for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Product Name & Other Names: Vitamin K1 or Phytomenadione or Phytonadione.
CAS Number: 84-80-0 or 12001-79-5
EINECS EC Code: 201-564-2

Skin: Rinse with water. Soap may be used. Seek Medical Aid.
Eyes: Wash eyes with plenty of water for at least 15 minutes, lifting lids occasionally. Seek Medical Aid.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Ingestion: If swallowed, induce vomiting immediately after giving two glasses of water. Never give anything by mouth to an unconscious person.

Flammability of the Product: Flammable in high concentration of dust in air.
Products of Combustion: Oxides of Carbon.
Fire Fighting Media and Instructions: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to legal requirements.
Large Spill: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow it to evacuate as per law.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling it. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep the container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents.

Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume, or mist, use ventilation to keep exposure to airborne contaminants low.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Physical state and appearance: Yellow fine powder.
Odor: Not available.
Odor threshold: Not available.
pH (5% soln/water): Not available.
Relative density: Not available.
Melting point/freezing point: Not available.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Practically insoluble in water, sparingly soluble in ethanol (96 per cent), miscible with fatty oils.
Viscosity: Not available.
Molecular Formula: C31H46O2
Molecular Weight: 450.7

Stability: It is stable in room temperature in closed containers under normal storage & handling.
Conditions of instability: Incompatible materials, Moisture, light, heat.
Incompatibility with various substances: Avoid high temperatures, sparks, open flames, and moisture. Avoid contact with strong oxidizing agents.
Polymerization: Will not occur.

Section 11: Toxicological Information
LD50 Oral - Rat: >33487 mg/kg
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as possible or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Teratogenic Effects: Not available.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.

Toxicity to fish: No information available.
Persistence and Degradability: No information available.
Mobility: No information available.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.

Waste Disposal: Waste must be disposed of in accordance with federal, state, and local environmental control regulations.

DOT USA: Not dangerous goods.
IMDG: Not dangerous goods.
IATA: Not dangerous goods.
ADR/RID Europe: Not dangerous goods.

USA Regulations:
California Prop 65: California No Significant Risk Level: None of the chemicals in this product are listed.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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