Niacin or Nicotinic Acid or Pyridine-3-Carboxylic Acid or Vitamin B3 USP BP Ph Eur FCC Food Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Niacin or Nicotinic Acid or Pyridine-3-Carboxylic Acid or Vitamin B3, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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Niacin or Nicotinic Acid or Pyridine-3-Carboxylic Acid or Vitamin B3 CAS Number 59-67-6, EINECS EC Number: 200-441-0, Molecular Formula: C6H5NO2 or 3-(COOH)-C5H4N, Molecular Weight: 123.11, HS Code 29362920

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Niacin or Nicotinic Acid or Pyridine-3-Carboxylic Acid or Vitamin B3.

Niacin or Nicotinic Acid or Pyridine-3-Carboxylic Acid or Vitamin B3 as a dietary supplement is used to treat pellagra, a disease caused by niacin deficiency. It is an essential human nutrient. Many countries mandate its addition to wheat flour or other food grains. Niacin is both a vitamin, i.e., an essential nutrient, marketed as a dietary supplement, and in the prescription medicine.
General Properties and Specifications of Nicotinic Acid or Niacin or Pyridine-3-Carboxylic Acid or Vitamin B3:

Appearance: White to off-white translucent crystals.
Odor: Odorless.
Assay: 99%
Heavy metals: 0.001% maximum.
Sulfated ash: 0.1% maximum.
Appearance of 5% water solution in NaoH: Clear and colorless to slight yellow.
Relative density: 1.47
Melting point: 234C and 238C literature.
Flash point: 193C literature.
Loss on drying: 0.1% maximum.
Auto-ignition temperature: 365C literature.
Solubility: Slightly soluble in water and in ethanol at room temperature. Freely soluble in boiling water and ethanol.

Niacin USP Grade Specifications:
C6H5NO2 --- 123.11
3-Pyridinecarboxylic acid;
Nicotinic acid CAS 59-67-6
UNII: 2679MF687A

DEFINITION
Niacin contains NLT 98.0% and NMT 102.0% of niacin (C6H5NO2 ), calculated on the dried basis.

IDENTIFICATION
A. Infrared Absorption
B. Ultraviolet Absorption
C. The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.
ASSAY
Acceptance criteria: 98.0%–102.0% on the dried basis
Residue on Ignition: NMT 0.1%
Chloride and Sulfate, Chloride: Acceptance criteria: NMT 0.02%
Chloride and Sulfate, Sulfate: Acceptance criteria: NMT 0.02%
Related Compounds: To pass the test.
Loss on Drying at 105C for 1hr: NMT 1.0%
Packaging and Storage: Preserve in well-closed containers.

Nicotinic Acid BP Ph Eur Grade Specifications:
C6H5NO2 --- 123.1 CAS 59-67-6
Action and use: Component of vitamin B.
Preparation: Nicotinic Acid Tablets

DEFINITION
Pyridine-3-carboxylic acid.
Content: 99.5 per cent to 100.5 per cent (dried substance).

CHARACTERS
Appearance: White or almost white, crystalline powder.
Solubility: Sparingly soluble in water, soluble in boiling water and in boiling ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides and carbonates.

IDENTIFICATION
First identification: A, B
Second identification: A, C
A. Melting point: 234C to 240.
B. Infrared absorption spectrophotometry.
C. Ultraviolet and visible absorption spectrophotometry. To pass the tests.

TESTS
Related substances: To pass the tests.
Chlorides: Maximum 200 ppm.
Loss on drying: Maximum 1.0 per cent, determined on 1.000 g by drying in an oven at 105C for 1 h.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
ASSAY
Dissolve 0.250 g in 50 mL of water. Add 0.25 mL of phenolphthalein solution. Titrate with 0.1 M sodium hydroxide until a pink colour is obtained. Carry out a blank titration.
1 mL of 0.1 M sodium hydroxide is equivalent to 12.31 mg of C6H5NO2.

Niacin FCC Food Grade Specifications:
Nicotinic Acid; 3-Pyridinecarboxylic Acid
C6H5NO2 Formula weight --- 123.11
CAS 59-67-6

DESCRIPTION
Niacin occurs as white or light-yellow crystals or as a crystalline powder. One gram of sample dissolves in 60 mL of water. It is freely soluble in boiling water and in boiling alcohol and also in a solutions of alkali hydroxides and carbonates. It is almost insoluble in ether.
Function: Nutrient.

REQUIREMENTS
Identification:
A. The infrared absorption spectrum of a mineral oil dispersion of the sample, previously dried at 105C for 1 h, exhibits maxima only at the same wavelengths as those of a similar preparation of USP Niacin Reference Standard.
B. Dissolve about 50mg of sample in 20mLof water, neutralize to litmus paper with 0.1 N sodium hydroxide, and add 3 mL of cupric sulfate. A blue precipitate gradually forms.
C. Determine the absorbance of a solution containing 20 µg of sample in each milliliter of water, in a 1-cm cell, at 237 nm and 262 nm, using water as the blank. The ratio A237/A262 is between 0.35 and 0.39.
Assay: Not less than 99.5% and not more than 101.0% of C6H5NO2, calculated on the dried basis.
Loss on Drying: Not more than 1.0%.
Melting Range: Between 234C and 238C.
Residue on Ignition: Not more than 0.1%.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

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Niacin or Nicotinic Acid or Pyridine-3-Carboxylic Acid or Vitamin B3 SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 14-Aug-23

Product Name & Other Names: Niacin or Nicotinic Acid or Pyridine-3-Carboxylic Acid or Vitamin B3.
CAS No.: 59-67-6
EINECS: EC Number: 200-441-0
Molecular Weight: 123.11
Molecular Formula: C6H5NO2 or 3-(COOH)-C5H4N
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Supplier: As per letterhead above.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Precautionary statements:
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash skin thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352-IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/ attention.
P362: Take off contaminated clothing and wash before reuse.
P501: Dispose of contents/container in accordance with local/regional/national/international regulations.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
Xi Irritant
Risk Phrases:
R36 Irritating to eyes skin.

Product Name & Other Names: Niacin or Nicotinic Acid or Pyridine-3-Carboxylic Acid or Vitamin B3.
CAS No.: 59-67-6
EINECS: EC Number: 200-441-0

Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

Flammability of the Product: Combustible at high temperature.
Auto-Ignition Temperature: 365C literature.
Flash Points: 193C literature.
Products of Combustion: Nitrogen oxides, Carbon dioxide, Carbon monoxide, fumes.
Fire Extinguishing Media: Use any means suitable for extinguishing surrounding fire. Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and a suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation. Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill: Contain spilled material. Avoid touching the spilled material. Do not let the product enter drains. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a disposal container.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Do not ingest. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents, strong acids, strong bases.

Airborne Exposure Limits: Not Established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: White to off-white translucent crystals.
Odor: Odorless.
Odor threshold: Not available.
pH: Not available.
Relative density: 1.47 literature.
Boiling Point: 204C to 206C.
Melting Point: 234C and 238C literature.
Flash point: 193C literature.
Auto-ignition temperature: 365C literature.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Slightly soluble in water and in ethanol at room temperature. Freely soluble in boiling water and ethanol.
Viscosity: Not available.
Molecular Weight: 123.11
Molecular Formula: C6H5NO2 or 3-(COOH)-C5H4N

Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: It emits Oxides of Nitrogen, Carbon dioxide, Carbon monoxide & Fumes.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents, strong acids, strong bases.
Conditions to Avoid: Incompatibles, heat & light, spark, flame.

Toxicity data
LD50 Oral - Rat - > 7 g/kg
LD50 Dermal - Rat - > 2,000 mg/kg
Carcinogenic Effects: Not know as carcinogen.
Mutagenic Effects: Not available.
Reproductive Effects: No information available.

Toxicity to fish: static test LC50 - Salmo trutta - 520 mg/l - 96 h.
Persistence and Degradability: Soluble in water Persistence is unlikely based on information available.
Mobility: Will likely be mobile in the environment due to its water solubility.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with law.

DOT USA, TDG Canada & ADR/RID Europe: Not regulated
IATA & IMDG/IMO: Not regulated.

USA:
SARA 311/312 Hazards: Immediate Health Hazard. See section 2.
California prop. 65: Contains no chemical subject to California Prop 65.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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