Methylparaben or Methyl paraben BP USP NF FCC Food Grade Methyl Hydroxybenzoate Methyl Parahydroxybenzoate Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Methylparaben or Methyl paraben, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal etc.

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Methylparaben or Methyl paraben: CAS Number: 99-76-3, EINECS EC Number: 202-785-7, Molecular Formula: C8H8O3, Molecular Weight: 152.15, HS Code ---**

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Methylparaben or Methyl paraben or Methyl Hydroxybenzoate or Methyl Parahydroxybenzoate.

Parabens are a class of widely used preservatives in cosmetic and pharmaceutical products. Chemically, they are a series of parahydroxybenzoates or esters of parahydroxybenzoic acid (also known as 4-hydroxybenzoic acid). Parabens are effective preservatives in many types of formulas. These compounds, and their salts, are used primarily for their bactericidal and fungicidal properties. They are found in shampoos, commercial moisturizers, shaving gels, personal lubricants, topical/parenteral pharmaceuticals, suntan products, makeup, and toothpaste. They are also used as food additives. Parabens are active against a broad spectrum of microorganisms.

Parabens are esters of para-hydroxybenzoic acid, from which the name is derived. Common parabens include methylparaben (E number E218), ethylparaben (E214), propylparaben (E216), butylparaben and heptylparaben (E209). Less common parabens include isobutylparaben, isopropylparaben, benzylparaben and their sodium salts. All commercially used parabens are synthetically produced, although some are identical to those found in nature. They are produced by the esterification of para-hydroxybenzoic acid with the appropriate alcohol, such as methanol, ethanol, or n-propanol.

Methylparaben, also methyl paraben, one of the parabens, is a preservative with the chemical formula CH3(C6H4(OH)COO). It is the methyl ester of p-hydroxybenzoic acid. It is also used as a food preservative and has the E number E218.

Methyl Hydroxybenzoate BP Grade
Methylparaben
Methyl Parahydroxybenzoate, Ph Eur
C8H8O3 --- 152.1 --- CAS 99-763-3
Action and use: Antimicrobial preservative.

DEFINITION
Methyl 4-hydroxybenzoate.
Content: 98.0 per cent to 102.0 per cent.

CHARACTERS
Appearance: White or almost white, crystalline powder or colourless crystals.
Solubility: Very slightly soluble in water, freely soluble in alcohol and in methanol.

IDENTIFICATION
First identification A, B.
Second identification A, C, D.
A. Melting point: 125C to 128C.
B. Infrared absorption spectrophotometry. Comparison methyl parahydroxybenzoate CRS.
C. Examine the chromatograms obtained in the test for related substances.
Results: The principal spot in the chromatogram obtained with test solution (b) is similar in position and size to the principal spot in the chromatogram obtained with reference solution (b).
D. To about 10 mg in a test-tube add 1 ml of sodium carbonate solution, boil for 30 s and cool (solution A). To a further 10 mg in a similar test-tube add 1 ml of sodium carbonate solution; the substance partly dissolves (solution B). Add at the same time to solution A and solution B 5 ml of aminopyrazolone solution and 1 ml of potassium ferricyanide solution and mix. Solution B is yellow to orange-brown. Solution A is orange to red, the colour being clearly more intense than any similar colour which may be obtained with solution B.

TESTS
Solution S: Dissolve 1.0 g in alcohol and dilute to 10 ml with the same solvent.
Appearance of solution: Solution S is clear and not more intensely coloured than reference solution.
Acidity: To 2 ml of solution S add 3 ml of alcohol, 5 ml of carbon dioxide-free water and 0.1 ml of bromocresol green solution. Not more than 0.1 ml of 0.1 M sodium hydroxide is required to change the colour of the indicator to blue.
Related substances: To pass the test (0.5 per cent).
Sulphated ash: Maximum 0.1 per cent, determined on 1.0 g.

ASSAY
To 1.000 g add 20.0 ml of 1 M sodium hydroxide. Heat at about 70C for 1 h. Cool rapidly in an ice bath. Prepare a blank in the same manner. Carry out the titration on the solutions at room temperature. Titrate the excess sodium hydroxide with 0.5 M sulphuric acid , continuing the titration until the second point of inflexion and determining the end-point potentiometrically.
1 ml of 1 M sodium hydroxide is equivalent to 152.1 mg of C8H8O3.

IMPURITIES
A. R = H: 4-hydroxybenzoic acid,
B. R = CH2-CH3: ethyl 4-hydroxybenzoate,
C. R = CH2-CH2-CH3: propyl 4-hydroxybenzoate,
D. R = CH2-CH2-CH2-CH3: butyl 4-hydroxybenzoate.

Methylparaben USP NF Grade
C8H8O3 152.15
Benzoic acid, 4-hydroxy-, methyl ester.
Methyl p-hydroxybenzoate [CAS 99-76-3].
Methylparaben contains not less than 98.0 percent and not more than 102.0 percent of C8H8O3.

Identification:
A: Infrared Absorption 197M.
B: Melting range: between 125C and 128C.
Color of solution: Dissolve 1 g in alcohol, dilute with alcohol to 10 mL, and mix (Methylparaben solution). This solution is clear and not more intensely colored than alcohol or a solution prepared immediately before use by mixing 2.4 mL of ferric chloride, 1.0 mL of cobaltous chloride, and 0.4 mL of cupric sulfate CS with 0.3 N hydrochloric acid to make 10 mL, and diluting 5 mL of this solution with 0.3 N hydrochloric acid to make 100 mL. Make the comparison by viewing the solutions downward in matched color-comparison tubes against a white surface.
Acidity: To 2 mL of Methylparaben solution prepared in the Color of solution test add 3 mL of alcohol, 5 mL of carbon dioxide-free water, and 0.1 mL of bromocresol green, and titrate with 0.10 N sodium hydroxide: not more than 0.1 mL is required to produce a blue color.
Residue on ignition: not more than 0.1%, determined on 1.0 g.
Related substances: To pass the test.
Assay: To about 1.000 g of Methylparaben, accurately weighed, add 20.0 mL of 1 N sodium hydroxide, and heat at about 70 for 1 hour. Cool rapidly in an ice bath. Carry out the titration on the solutions at room temperature. Titrate the excess sodium hydroxide with 1 N sulfuric acid, continuing the titration until the second point of inflection and determining the endpoint potentiometrically. Perform a blank. Each mL of 1 N sodium hydroxide is equivalent to 152.1 mg of C8H8O3.

Methylparaben FCC Food Grade
Methyl p-Hydroxybenzoate
HO COOCH3
C8H8O3 Formula wt 152.15
INS: 218 CAS: [99-76-3]
DESCRIPTION
Methylparaben occurs as small, colorless crystals or as a white, crystalline powder. One gram dissolves in about 400 mL of water at 25C, in about 50 mL of water at 80C, in about 2.5 mL of alcohol, in about 7 mL of ether, and in about 4 mL of propylene glycol. It is slightly soluble in glycerin and in fixed oils.
Function: Preservative; antimicrobial agent.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

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Methyl Paraben SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 06-Nov-20

Product Name & Other Names: Methyl Paraben, Methyl 4-Hydroxybenzoate
CAS No.: 99-76-3
EINECS EC Number: 202-785-7
Molecular Formula: C8H8O3
Molecular Weight: 152.15
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Skin irritation Category 2, H315
Serious eye damage/eye irritation Category 2A, H319
Specific target organ toxicity - single exposure, Target Organs - Respiratory system. Category 3, H335

Hazard statements:
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
Precautionary statements:
P264: Wash … thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P337+P313: If eye irritation persists: Get medical advice/ attention.
P362: Take off contaminated clothing and wash before reuse.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
Xi: Irritant
Risk Phrases:
R36/37/38 Irritating to eyes, respiratory system, and skin.

Product Name & Other Names: Methyl Paraben, Methyl 4-Hydroxybenzoate
CAS No.: 99-76-3
EINECS EC Number: 202-785-7

Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen and get medical attention immediately.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention. Wash clothing and shoes before reuse.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

Fire: As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source.
Explosion: Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard.
Fire Extinguishing Media: Water spray, dry chemical, alcohol foam, or carbon dioxide.
Hazardous decomposition products formed under fire conditions: Carbon oxides.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Ensure adequate ventilation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil or water sources.
Methods and materials used for containment Cleanup procedures and Storage:
Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Avoid generation of dust during clean-up of spills. Use a soft bristle brush or conductive rubber or conductive plastic shovel. Use caution, material is sensitive to initiation from sources such as heat, flame, shock, friction, or sparks. Use only non-sparking tools.
Large Spill: Contain spilled material. Pick up or sweep and place in suitable disposal container. Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray to reduce vapors. Prevent entry into sewers, basements, or confined areas; dike if needed. Eliminate all ignition sources.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizers, acids, and bases. May form combustible dust concentrations in air. Use care during processing to minimize generation of dust. Containers may be hazardous when empty. Avoid dust formation and control ignition sources. Employ grounding, venting and explosion relief provisions in accord with accepted engineering practices in any process capable of generating dust and/or static electricity.

Airborne Exposure Limits: None established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator (NIOSH type N95 or better filters) may be worn. If oil particles (e.g. lubricants, cutting fluids, glycerin, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: White crystals or powder.
Odor: Odorless.
Odor threshold: Not available.
pH: 1.0 - 2 at 150 g/l at 25C (77F).
Relative density: 1.38
Boiling Point: 270-280C
Melting Point: 125-131C
Flash point: Not available.
Auto-ignition Temperature: > 403C
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor Density (Air=1): 5.23
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Slightly soluble in water.
Viscosity: Not available.
Molecular Formula: C8H8O3
Molecular Weight: 152.15

Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: Carbon dioxide and carbon monoxide may form when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizers, acids and bases.
Conditions to Avoid: Direct sunlight. Extremely high or low temperatures, Heat, dusting, and incompatibles.

LD50 oral rat: 2100 mg/kg
LD50 Oral mouse: > 8,000 mg/kg
LD50 dermal rat: NA
LD50 Intravenous - mouse - 485 mg/kg
LD 50 Oral Rabbit: 6000 mg/kg
Carcinogenicity: Not know to be or anticipated to be a carcinogen.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.
Teratogenicity: no data available.

EC50 Daphnia: 0.56 mg/l.
LC50 Fish: 59.5 mg/l
Results of PBT and vPvB assessment: This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Mobility in soil: No data available.

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused material in accordance with legal requirements.

DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods.

USA:
SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313: This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards: Acute Health Hazard
SARA 313 (TRI reporting): Not applicable.
California Prop. 65 Components: This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.

European Labeling in Accordance with EC Directives:
H315 = Causes skin irritation.
H319 = Causes serious eye irritation.
H335 = May cause respiratory irritation.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
Xi: Irritant
Risk Phrases:
R36/37/38 Irritating to eyes, respiratory system, and skin.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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