Activated Dimethicone or Simethicone and Simethicone Emulsion Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Activated Dimethicone or Simethicone and Simethicone Emulsion, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal etc.

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Activated Dimethicone or Simethicone and Simethicone Emulsion: CAS Number: 8050-81-5, EINECS EC Number: 617-098, Molecular Formula: (C2H6OSi)n-SiO2, Molecular Weight: Varies, HS Code ---**

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Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Activated Dimethicone or Simethicone and Simethicone Emulsion.

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SDS MSDS Sheet of Activated Dimethicone or Simethicone and Simethicone Emulsion Manufacturers

Activated Dimethicone
Simethicone and Simethicone Emulsion Pure Suppliers
Activated Dimethicone Simethicone Emulsion

Activated Dimethicone or Simethicone, USP is an antifoaming agent that is used to reduce bloating from excessive gas. Activated Dimethicone IP (Simethicone IP) an active ingredient in many antacids, anti - flatulent preparations that causes small air bubbles in the intestines to coalesce and pass out easily. Can be easily incorporated into various Antacid - Anti Flatulent pharmaceutical formulations such as tablets & suspensions. It also finds its application in distilleries & food processing industries.

Specifications of Simeticone BP Ph Eur Grade:
Action and use: Silicon dioxide analogue; defoaming agent.

DEFINITION
Simeticone is prepared by incorporation of 4 per cent to 7 per cent silica into poly (dimethylsiloxane) with a degree of polymerization between 20 and 400.
Content: 90.5 per cent to 99.0 per cent of poly(dimethylsiloxane).

PRODUCTION
Poly(dimethylsiloxane) is obtained by hydrolysis and polycondensation of dichlorodimethylsilane and chlorotrimethylsilane and the silica is modified at the surface by incorporation of methylsilyl groups.

CHARACTERS
Appearance: Viscous, greyish-white, opalescent liquid.
Solubility: Practically insoluble in water, very slightly soluble or practically insoluble in anhydrous ethanol, practically insoluble in methanol, partly miscible with ethyl acetate, with methylene chloride, with methyl ethyl ketone and with toluene.

IDENTIFICATION
A. Infrared absorption spectrophotometry.
B. Heat 0.5 g in a test-tube over a small flame until white fumes begin to appear. Invert the tube over a 2nd tube containing 1 ml of a 1 g/l solution of chromotropic acid, sodium salt in sulphuric acid so that the fumes reach the solution. Shake the 2nd tube for about 10 seconds and heat on a water-bath for 5 minutes. The solution is violet.
C. The residue obtained in the test for silica under Assay, gives the reaction of silicates.

TESTS
Acidity: To 2.0 g add 25 ml of a mixture of equal volumes of anhydrous ethanol and ether previously neutralized to 0.2 ml of bromothymol blue solution and shake. Not more than 3.0 ml of 0.01 M sodium hydroxide is required to change the color of the solution to blue.
Defoaming activity:
Foaming solution: Dissolve 5.0 g of docusate sodium in 1 liter of water, warm to 50C if necessary.
Defoaming solution: To 50 ml of methyl ethyl ketone add 0.250 g of the substance to be examined, warm to not more than 50C with shaking. Into a 250 ml cylindrical tube about 5 cm in diameter introduce 100 ml of foaming solution and 1 ml of defoaming solution. Close tightly and fix the tube on a suitable oscillating shaker that complies with the following conditions:
— 250-300 oscillations per minute;
— angle of oscillation of about 10;
— oscillation radius of about 10 cm.
Shake for 10 seconds and record the time between the end of the shaking and the instant the 1st portion of foam-free liquid surface appears.
This duration is no longer than 15 seconds.
Mineral oils: Place 2.0 g in a test-tube and examine in ultraviolet light at 365 nm. The fluorescence is not more intense than that of a solution containing 0.1 ppm of quinine sulphate in 0.005 M sulphuric acid examined in the same conditions.
Phenylated compounds: To pass the test.
Heavy metals: Maximum 5 ppm.
Volatile matter: Maximum 1.0 per cent, determined on 1.00 g by heating in an oven at 150C for 2 h. Carry out the test using a dish 60 mm in diameter and 10 mm deep.


Specifications of Simethicone USP NF Grade:
-(Trimethylsilyl)- -methylpoly[oxy(dimethylsilylene)], mixture with silicon dioxide ---8050-81-5.

Simethicone is a mixture of fully methylated linear siloxane polymers containing repeating units of the formula [–(CH3)2SiO–]n, stabilized with trimethylsiloxy end-blocking units of the formula [(CH3)3 SiO–], and silicon dioxide. It contains not less than 90.5 percent and not more than 99.0 percent of polydimethylsiloxane ([–(CH3)2SiO–]n), and not less than 4.0 percent and not more than 7.0 percent of silicon dioxide.

Packaging and storage: Preserve in tight containers.
Identification: Infrared Absorption.
Defoaming activity:
Foaming solution: Dissolve 1 g of octoxynol 9 in 100 mL of water.
Test preparation: Transfer 200 mg of Simethicone to a 60-mL bottle, add 50 mL of tertiary butyl alcohol, cap the bottle, and shake vigorously. [NOTE—Warm slightly, if necessary, to dissolve.]
Procedure: [NOTE—For each test, employ a clean, unused, 250-mL glass jar.] Add, dropwise, 500 microL of the Test preparation to a clean, unused, cylindrical 250-mL glass jar, fitted with a 50-mm cap, containing 100 mL of the Foaming solution. Cap the jar and clamp it in an upright position on a wrist-action shaker. Employing a radius of 13.3 ± 0.4 cm (measured from center of shaft to center of bottle), shake for 10 seconds through an arc of 10 degrees at a frequency of 300 ± 30 strokes per minute. Record the time required for the foam to collapse. The time, in seconds, for foam collapse is determined at the instant the first portion of foam-free liquid surface appears, measured from the end of the shaking period. The defoaming activity time does not exceed 15 seconds.
Loss on heating: Heat about 15 g, accurately weighed, in an open, tared vessel having a diameter of 5.5 ± 0.5 cm and a wall height of 2.5 ± 1.0 cm at 200 in a circulating air oven for 4 hours, and allow to come to room temperature in a desiccator before weighing: it loses not more than 18.0% of its weight.
Heavy metals: To pass the test (5 microg per g).
Content of silicon dioxide: To pass the test.


Simethicone Emulsion USP NF Grade:

Simethicone Emulsion is a water-dispersible form of Simethicone composed of Simethicone, suitable emulsifiers, preservatives, and water. It may contain suitable viscosity-increasing agents. It contains an amount of polydimethylsiloxane ([–(CH3)2SiO–]n) that is not less than 85.0 percent and not more than 110.0 percent of the labeled amount of simethicone.

Packaging and storage: Preserve in tight containers.
Identification: The IR absorption spectrum.
Microbial limits: Its total aerobic microbial count does not exceed 100 cfu per g.
Heavy metals: To pass the test -- The limit is 5 microg per g.
Defoaming activity: To pass the test -- The defoaming activity time does not exceed 15 seconds.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

Manufacturers:

MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +912223770100, +912223726950
Current Date Time in India GMT+5:30

e-mail: info@mubychem.com

USA, Canada, Mexico and other American
neighbouring buyers may
e-mail: us@mubychem.com
Call toll-free 1-844-682-9243 (1-844-MUBYCHEM)

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Copyright and Usual Disclaimer is Applicable.
Last 27 August, 2022

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Activated Dimethicone or Simethicone SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet
16-Nov-20

Section 1: Chemical Product and Company Identification

Product Name & Other Names: Activated Dimethicone or Simethicone.
CAS Number: 8050-81-5
EINECS EC Code: 617-098
Molecular Formula: (C2H6OSi)n-SiO2
Molecular Weight: Varies.
Recommended usage: Industrial Manufacturing.
Suppliers: As per letterhead.

Section 2: Hazards Identification

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Hazard Class and Category Code(s), Regulation (EC) No 1272/2008 (CLP)

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Labeling Regulation as per GHS & EC 1272/2008 (CLP) & GHS

GHS Label Elements
NONE

Signal Word: None

Hazards not otherwise classified (HNOC):
May causes mild skin irritation.
May causes mild eye irritation.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352 - IF ON SKIN: Wash with plenty of soap and water.
P303+P361+P353 - IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

Section 3: Composition and Information on Ingredients

Product Name & Other Names: Activated Dimethicone or Simethicone.
CAS Number: 8050-81-5
EINECS EC Code: 617-098

Section 4: First Aid Measures

Always seek medical advice after the first aid treatment.

Skin: Rinse with water. Soap may be used. Seek Medical Aid.
Eyes: Wash eyes with plenty of water for at least 15 minutes, lifting lids occasionally. Seek Medical Aid.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Ingestion: If swallowed, induce vomiting immediately after giving two glasses of water. Never give anything by mouth to an unconscious person.

Section 5: Fire and Explosion Data

Flammability of the Product: It is flammable on heating.
Products of Combustion: Oxides of Carbon, Silicone and fumes.
Fire Fighting Media and Instructions: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Section 6: Accidental Release Measures

Personal precautions, protective equipment and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Ensure adequate ventilation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil or water sources.
Methods and materials used for containment Cleanup procedures and Storage:
Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to legal requirements.
Large Spill: Do not inhale vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.

Section 7: Handling and Storage

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat or smoke while handling. Avoid contact with skin, eyes and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing agents, acids.

Section 8: Exposure Controls/Personal Protection

Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants low.
Exposure Guidelines: This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Section 9: Physical and Chemical Properties

Physical state and appearance: Clear viscous light gray liquid.
Odor: Not available.
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Melting point/freezing point: Not available.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Practically insoluble in water, very slightly soluble or practically insoluble in anhydrous ethanol, practically insoluble in methanol, partly miscible with ethyl acetate, with methylene chloride, with methyl ethyl ketone and with toluene.
Viscosity: Not available.
Molecular Formula: (C2H6OSi)n-SiO2
Molecular Weight: Varies.

Section 10: Stability and Reactivity Data

Stability: It is stable in room temperature in closed containers under normal storage & handling.
Conditions of instability: Incompatible materials, Heat.
Incompatibility with various substances: Avoid high temperatures, sparks, open flames and moisture. Avoid contact with strong oxidizing agents, acids.
Polymerization: Will not occur.

Section 11: Toxicological Information

LD50 Oral - Rat - Not available.
Carcinogenic Effects: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC, NTP, ACGIH, OSHA.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.

Section 12: Ecological Information

Toxicity to fish: No information available.
Persistence and Degradability: No information available.
Mobility: No information available.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.

Section 13: Disposal Considerations

Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations.

Section 14: Transport Information

DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
IMDG/IMO: Not dangerous goods.
IATA: Not dangerous goods.

Section 15: Other Regulatory Information

USA Regulations:
OSHA: None of the chemicals in this product are considered highly hazardous by OSHA.
California Prop 65: California No Significant Risk Level: None of the chemicals in this product are listed.

Section 16 - Additional Information

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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