1,2-Dioleyloxy-3-dimethylamino-propane or Cationics DODMA or N,N-dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of 1,2-Dioleyloxy-3-dimethylamino-propane, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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1,2-Dioleyloxy-3-dimethylamino-propane or Cationics DODMA or N,N-dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine: CAS Number: 104162-47-2, EINECS EC Number: NA, Molecular Formula: C41H81NO2, Molecular Weight: 620.09, HS Code ---**

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for 1,2-Dioleyloxy-3-dimethylamino-propane or Cationics DODMA or N,N-dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine.

Cationics DODMA
1,2-Dioleyloxy-3-dimethylamino-propane or Cationics DODMA or N,N-dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine

1,2-Dioleyloxy-3-dimethylamino-propane or Cationics DODMA or N,N-dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of lipospomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.

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1,2-Dioleyloxy-3-dimethylamino-propane or Cationic DODMA or N,N-dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine SDS Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 25-Nov-20

Product Name & Other Names: 1,2-Dioleyloxy-3-dimethylamino-propane or Cationic DODMA or N,N-dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine.
CAS No.: 104162-47-2
EINECS EC Code: NA
Molecular Weight: 620.09
Chemical Formula: C41H81NO2
Relevant uses and uses advised against (if any): Laboratory and R&D in Industrial Manufacturing.
Suppliers: As per letterhead

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Hazards: 1,2-Dioleyloxy-3-dimethylamino-propane is non-hazardous. However, if its solution is used, then the hazards related to its solvent are applicable.

Hazards not otherwise classified (HNOC):
The toxicology properties of this item are not fully studied and hence it should be handled with a lot of precautions.

Precautionary Statements
P220: Keep/Store away from clothing/other combustible materials.
P221: Take any precaution to avoid mixing with combustibles.
P234 Keep only in original container.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P272: Contaminated work clothing should not be allowed out of the workplace
P273 Avoid release to the environment.
P280-Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P301+P310+330: IF SWALLOWED: Rinse mouth and immediately call a POISON CENTER or doctor/physician.
P302+P352: IF ON SKIN: Wash with soap and water.
P303 + P361 + P352 IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P304 + P341 + P311 IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P310 Immediately call a POISON CENTER or doctor/physician.
P314: Get Medical advice/attention if you feel unwell.
P330: If swallowed, rinse mouth.
P308+313: IF exposed or concerned: Get medical advice/attention.
P337+P313 If eye irritation persists: Get medical advice/ attention.
P360: Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P363: Wash contaminated clothing before reuse.

Product Name & Other Names: 1,2-Dioleyloxy-3-dimethylamino-propane or Cationic DODMA or N,N-dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine.
CAS No.: 104162-47-2
EINECS EC Code: NA

The product may also be supplied in a solvent like ethanol or chloroform. 1,2-Dioleyloxy-3-dimethylamino-propane is non-hazardous. However, if its solution is used, then the hazards related to its solvent are applicable.

Inhalation: If inhaled, it may cause irritation and damage to nose and throat. It can cause headache, bleeding from nose coughing and chest discomfort. Remove the victim to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: It may cause irritation and burns to mouth, digestive tract and stomach. It may lead to pain, nausea, vomiting, and even collapse. Contact medical center quickly. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: On contact, it may cause itching, pain, swelling and redness. Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: It may cause damage to eyes. Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Get medical attention.

Fire: Flash point: NA.
Toxic fumes, carbon dioxide, carbon monoxide and nitrogen oxides may be formed in fire.
Fire Extinguishing Media: Dry chemical, foam or carbon dioxide and water spray jet.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

If supplied as a solution in a solvent, fire hazard of the solvent is applicable.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil or water sources.
Methods and materials used for containment Cleanup procedures and Storage:
Small Spill: Mop and pick up the material and place in an appropriate waste disposal container. Soak up with inert absorbent material and dispose of as hazardous waste. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Avoid dust/mist formation. Wear full protective equipment and ensure proper ventilation. Keep away from heat. Keep away from sources of ignition. Provide ventilation. Vacuum or sweep up and remove to an approved disposal container. Contact Environment Agency.

Precautions for safe handling: Keep away from heat and source of fire preferably in a ventilated area. Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust/mist/vapor generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cold, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Keep locked up in tightly closed container. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Do not ingest. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing agents etc. Storage: -20C. Short term shipping may be at preferably with ice.

Airborne Exposure Limits: Not established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to the substance is apparent and engineering controls are not feasible, consult an industrial hygienist. For emergencies, or instances where the exposure levels are not known, use a full-face piece positive-pressure, air-supplied respirator. WARNING: Air purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: Colorless to dark yellow liquid.
Odor: Not available.
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Melting point/freezing point: Not available.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Soluble in ethanol and chloroform. DODMA is generally supplied as a solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice. DODMA is soluble in dimethyl formamide at a concentration of approximately 12 mg/ml. DODMA is sparingly soluble in aqueous solutions.
Viscosity: Not available.
Molecular Weight: 620.09
Chemical Formula: C41H81NO2

Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, nitrogen oxides (NOx) and toxic fumes may form when heated to decomposition.
Hazardous Polymerization: Not reported.
Incompatibilities: Oxidizing agents.
Conditions to Avoid: Heat, flames, ignition sources and incompatibles.

Acute toxicity: Not available.
Carcinogenic Effects: Not available. Not a reported carcinogen.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.

Environmental Toxicity: Not available.
Persistence and Degradability: No information available.
Mobility: No information available.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state, and local requirements.

DOT USA, TDG Canada & ADR/RID Europe: Not regulated.
IMDG/IMO & IATA/ICAO: No information available or not regulated.

15. Regulatory Information

USA:
California Proposition 65: Not listed.
SARA 311/312 Hazards: See section 2.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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