Sodium Salicylate BP Ph Eur USP Grade n Pure Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Sodium Salicylate, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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Sodium Salicylate: CAS Number: 54-21-7, EINECS EC Number: 200-198-0, Molecular Formula: HOC6H4COONa, Molecular Weight: 160.11, HS Code ---**

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Sodium Salicylate.

Sodium Salicylate is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug.

Sodium Salicylate BP Ph Eur Grade Specifications
Ph Eur
C7H5NaO3 -- 160.1 -- 54-21-7
Action and use: Anti-inflammatory; analgesic.

DEFINITION
Sodium 2-hydroxybenzenecarboxylate.
Content: 99.0 per cent to 101.0 per cent (dried substance).

CHARACTERS
Appearance: White or almost white, crystalline powder or small, colourless crystals or shiny flakes.
Solubility: Freely soluble in water, sparingly soluble in ethanol (96 per cent).

IDENTIFICATION
First identificationıA, C.
Second identificationıB, C.
A. Infrared absorption spectrophotometry.
B. Solution S (see Tests) gives the reactions of salicylates.
C. It gives reaction (b) of sodium.

TESTS
Solution S: Dissolve 5.0 g in carbon dioxide-free water prepared from distilled water and dilute to 50 ml with the same solvent.
Appearance of solution: Solution S is clear and not more intensely coloured than reference solution BY6.
Acidity: To 20 ml of solution S add 0.1 ml of phenol red solution. The solution is yellow. Not more than 2.0 ml of 0.01 M sodium hydroxide is required to change the colour of the indicator to violet-red.
Chlorides: Maximum 200 ppm.
Sulphates: Maximum 600 ppm.
Heavy metals: Maximum 20 ppm.
Loss on drying: Maximum 0.5 per cent, determined on 1.00 g by drying in an oven at 105C.

ASSAY
Dissolve 0.130 g in 30 ml of anhydrous acetic acid. Titrate with 0.1 M perchloric acid, determining the end-point potentiometrically.
1 ml of 0.1 M perchloric acid is equivalent to 16.01 mg of C7H5NaO3.

Sodium Salicylate USP Grade Specifications
C7H5NaO3 --- 160.10
Benzoic acid, 2-hydroxy-, monosodium salt.
Monosodium salicylate --- [54-21-7].

Sodium Salicylate contains not less than 99.5 percent and not more than 100.5 percent of C7H5NaO3, calculated on the anhydrous basis.

Packaging and storage: Preserve in well-closed, light-resistant containers.
Identification: A solution (1 in 20) responds to the tests for Sodium and for Salicylate.
Water: not more than 0.5%.
Sulfite or thiosulfate: Add 1 mL of hydrochloric acid to a solution of 1.0 g in 20 mL of water, and filter the liquid: not more than 0.15 mL of 0.10 N iodine is required to produce a yellow color in the filtrate.
Heavy metals: Dissolve 2 g in 46 mL of water. Add, with constant stirring, 4 mL of 3 N hydrochloric acid, filter, and use 25 mL of the filtrate: the limit is 0.002%.
Assay: Transfer about 700 mg of Sodium Salicylate, accurately weighed, to a 250-mL beaker. Add 100 mL of glacial acetic acid, stir until the sample is completely dissolved, add crystal violet, and titrate with 0.1 N perchloric acid. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 16.01 mg of C7H5NaO3.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

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Sodium Salicylate SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 06-Nov-20

Product Name & Other Names: Sodium Salicylate or 2-Hydroxybenzoic acid sodium salt, Salicylic acid sodium salt.
CAS No.: 54-21-7
EINECS EC Number: 200-198-0
Molecular Weight: 160.1
Chemical Formula: HOC6H4COONa
Relevant uses and uses advised against (if any): Industrial use only.
Suppliers: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Acute toxicity, Oral (Category 4), H302
Skin irritation (Category 2), H315
Eye irritation (Category 2), H319

Hazard statements:
H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.

Precautionary statements:
P264: Wash … thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P330: Rinse mouth.
P362: Take off contaminated clothing and wash before reuse.
P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302+352: IF ON SKIN: Wash with soap and water.
P332+313: If skin irritation occurs: Get medical advice/attention.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.
P501: Dispose of contents/container to authorized agents only.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbols:
Xn Harmful.
Xi = Irritant.
Risk Phrases:
R22 Harmful if swallowed.
R36/38 Irritating to eyes and skin.

Product Name & Other Names: Sodium Salicylate or 2-Hydroxybenzoic acid sodium salt, Salicylic acid sodium salt.
CAS No.: 54-21-7
EINECS EC Number: 200-198-0

Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

Flammability of the Product: May be combustible at high temperature.
Auto-Ignition Temperature: Not applicable.
Products of Combustion: Fumes, Metallic Oxide Carbon dioxide & Carbon Monoxide.
Fire: Sodium Salicylate is slightly flammable on heating.
Explosion: Slightly explosive on heating.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Use means suitable for extinguishing surrounding fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures or when moistened under fire conditions, it may produce toxic or irritating fumes. On decomposition it may emit carbon monoxide. Containers may explode on heating.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage:
Small Spill: Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation. Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents, acids, strong bases, ferric salts, lead acetate, lead, lime water, silver nitrate, iodine. Keep away from heat and sun light.

Airborne Exposure Limits: Not Specified.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: Colorless white powder flakes or crystals.
Odor: It is odorless.
Odor threshold: Not available.
pH: 5-6
Relative density: about 2.5
Melting point/freezing point: Not available.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: It is soluble in water.
Viscosity: Not available.
Molecular Weight: 160.1
Molecular formula: HOC6H4COONa

Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: It emits carbon monoxide & fumes when heated to decomposition. It may form metallic oxide harmful gases.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents, acids, strong bases, ferric salts, lead acetate, lead, lime water, silver nitrate, iodine.
Conditions to Avoid: Incompatible materials, light, dust generation, excess heat, exposure to moist air or water.

Toxicity data
ORL-RAT LD50 930 mg kg-1
ORL-Mouse LD50 540 mg kg-1
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as possible or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Mutagenic Effects: Mutagenic effects have occurred in experimental animals.
Teratogenic Effects: Teratogenic effects have occurred in experimental animals.
Developmental Toxicity: Adverse reproductive effects have occurred in experimental animals.

Toxicity to fish: LC50 - Pimephales promelas (fathead minnow) - 1.370 mg/l - 96 h
Environmental Fate: This substance is expected to have a high biological oxygen demand. It is readily biodegradable and has low bioconcentration potential.
Persistence and Degradability: Unlikely to persist due to water solubility.
Mobility: Likely to be mobile due to water solubility.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state, and local requirements.

DOT USA, TDG Canada & ADR/RID Europe: Not regulated.
IMDG/IMO & IATA: Not regulated.

OSHA Hazards: Not classed as Highly Hazardous as per OSHA
SARA 302 Components: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA Codes: CAS # 54-21-7: immediate, delayed. See section 2.
SARA 313 Components: No chemicals in this material are subject to the reporting requirements
California Prop. 65 Components: This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.

European Labeling in Accordance with EC Directives:
H302 = Harmful if swallowed.
H315 = Causes skin irritation.
H319 = Causes serious eye irritation.

DISCLAIMER: The information and recommendations set forth herein are presented in good faith and believed correct as of the date hereof. It is compiled from various sources and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules or insurance requirements applicable. This MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.

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