Cyanocobalamin or 5,6-Dimethylbenzimidazolyl cyanocobamide or Vitamin B12 Manufacturers, with SDS GHS MSDS Sheet |
Supplier, Manufacturer, Exporter of Cyanocobalamin or 5,6-Dimethylbenzimidazolyl cyanocobamide or Vitamin B12, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc. The products are offered as per required specifications and in correct shape and size in mm or meshs or microns as specified by the buyer. The participating units have one or more accreditations like FDA - cGMP and GLP approval, ISO-9001 Certified, "REACH" Registered, ISO-14001, ISO/IEC 17025, ISO-22000, FSSC 22000, ISO 45001, Kosher Certified, Halal Certified, HACCP, FSSAI. We offer Commercial Pure & IP BP EP Ph Eur USP NF JP FCC Food Grade Analytical Reagent Grades of Chemicals |
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Cyanocobalamin or 5,6-Dimethylbenzimidazolyl cyanocobamide or Vitamin B12 CAS Number 68-19-9, EINECS EC Number: 200-680-0, Molecular Formula: C63H88CoN14O14P, Molecular Weight: 1355.37, HS Code 29362610
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SDS MSDS Sheet of Cyanocobalamin or 5,6-Dimethylbenzimidazolyl cyanocobamide or Vitamin B12 Manufacturers
Cyanocobalamin
5,6-Dimethylbenzimidazolyl cyanocobamide or Vitamin B12 USP BP Ph Eur FCC Food Grade Suppliers
Cyanocobalamin is a form of vitamin B12 used to treat vitamin B12 deficiency. It is used in pharmaceutical industry and in supplements.
General Properties and Specifications of Cyanocobalamin or 5,6-Dimethylbenzimidazolyl cyanocobamide or Vitamin B12:
Appearance: Dark red powder or crystals.
Odor: Odorless.
Assay on dried basis: 96% to 102% minimum.
Loss on drying: 12% maximum.
Melting point: >300C.
Solubility: Slightly soluble in water.
Storage: 2C to 8C.
Cyanocobalamin USP Grade Specifications:
C63H88CoN14O14P -- 1355.37
Vitamin B12 --- CAS 68-19-9
UNII: P6YC3EG204
DEFINITION
Cyanocobalamin contains NLT 96.0% and NMT 102.0% of cyanocobalamin (C63H88CoN14O14P), calculated on the dried basis.
IDENTIFICATION
A. Ultraviolet Absorption: To pass the test.
B.
Sample solution: Fuse 1 mg of Cyanocobalamin with 50 mg of potassium pyrosulfate in a porcelain crucible. Cool, break up the mass with a glass rod, add 3 mL of water, and dissolve by boiling.
Analysis: Add 1 drop of phenolphthalein and add sodium hydroxide solution (100 mg/mL), dropwise, until just pink. Add 500 mg of sodium acetate, 0.5 mL of 1 N acetic acid, and 0.5 mL of nitroso salt solution (2 mg/mL). Add 0.5 mL of hydrochloric acid, and boil for 1 min.
Acceptance criteria: A red or orange-red color appears immediately after the addition of nitroso salt. The red color persists after boiling with the addition of hydrochloric acid.
C. HPLC: To pass the test.
Related Compounds: To pass the test by Chromatography.
Loss on Drying:
Sample: 25 mg.
Analysis: Dry the Sample in a suitable vacuum drying apparatus at 105C and at a pressure of NMT 5 mm of mercury for 2 h.
Acceptance criteria: NMT 12.0%
Packaging and Storage: Preserve in tight, light-resistant containers, and store at controlled room temperature.
Cyanocobalamin BP Ph Eur Grade Specifications:
C63H88CoN14O14P – 1355 – CAS 68-19-9
Action and use: Vitamin B12 analogue.
IDEFINITION
α-(5,6-Dimethylbenzimidazol-1-yl)cobamide cyanide.
Content: 96.0 per cent to 102.0 per cent (dried substance).
CHARACTERS
Appearance: Dark red, crystalline powder or dark red crystals.
Solubility: Sparingly soluble in water and in ethanol (96 per cent), practically insoluble in acetone.
The anhydrous substance is very hygroscopic.
IDENTIFICATION
A. Ultraviolet and visible absorption spectrophotometry: To pass the test.
B. Thin-layer chromatography: To pass the test.
Related substances: To pass the test by Liquid chromatography.
Loss on drying: Maximum 12.0 per cent, determined on 40.00 mg by drying in vacuo at 105C for 2 h.
STORAGE
In an airtight container, protected from light.
Vitamin B12 FCC Food Grade
Cyanocobalamin FCC Food Grade Specifications:
C63H88CoN14O14P Formula weight --- 1355.38
CAS 68-19-9
DESCRIPTION
Vitamin B12 occurs as dark red crystals or as an amorphous or crystalline powder. In the anhydrous form, it is very hygroscopic, and when exposed to air, it may absorb about 12% of water. It is sparingly soluble in water; soluble in alcohol; and insoluble in acetone, in chloroform, and in ether.
Function: Nutrient.
Identification:
A. The absorption spectrum of the Sample Solution used to measure absorbance in the Assay (below) exhibits maxima within _1 nm at 278 nm and 361 nm, and within _2 nm at 550 nm. The ratio A361/A278 is between 1.70 and 1.90, and the ratio A361/A550 is between 3.15 and 3.40.
B. Fuse about 1 mg of sample with about 50 mg of potassium pyrosulfate in a porcelain crucible, cool, and break up the mass with a glass rod. Add 3 mL of water, and dissolve by boiling. Add 1 drop of phenolphthalein, mix, and then add drops of a 1:10 solution of sodium hydroxide until just pink. Add 500 mg of sodium acetate, 0.5 mL of 1 N acetic acid, and 0.5 mL of a 1:500 solution of nitroso salt. A red or orange-red color appears at once. Add 0.5 mL of hydrochloric acid, and boil for 1 min. The red color persists.
C. Dissolve about 5 mg of sample in 5 mL of water contained in a 50-mL distilling flask connected to a short, watercooled, vertical condenser, the tip of which dips into a test tube containing 1 mL of a 1:50 solution of sodium hydroxide. Add 2.5 mL of hypophosphorous acid to the flask, then close the flask, heat at simmering for 10 min, and distill 1 mL into the test tube. Add 4 drops of cold, saturated ferrous ammonium sulfate solution to the tube, shake gently, then add about 30 mg of sodium fluoride, and bring the contents to a boil. Immediately add drops of 1:7 sulfuric acid until a clear solution results, and then add 3 to 5 drops more of the acid. A blue or blue-green color appears within a few minutes.
Assay: Not less than 96.0% and not more than 100.5% of C63H88CoN14O14P, calculated on the dried basis.
Loss on Drying: Not more than 12.0%.
Pseudo Cyanocobalamin: Passes test.
For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.
We also manufacture and supply as under:
Acetone Cyanohydrin or 2-Hydroxyisobutyronitrile
Biotin or D-Biotin or Vitamin B7 or Vitamin H
Niacin or Nicotinic Acid Vitamin B3
Thiamine Hydrochloride or Vitamin B1.
Manufacturers:
MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +912223770100, +912223726950
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e-mail: info@mubychem.com
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Last
15 July, 2024
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Cyanocobalamin or Vitamin B12 SDS Sheet, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 02-Jul-23
1. Product Identification
Product Name & Other Names: Cyanocobalamin or 5,6-Dimethylbenzimidazolyl cyanocobamide or Vitamin B12.
CAS No.: 68-19-9
EINECS EC Code: 200-680-0
Molecular Weight: 1355.37anhydrous.
Chemical Formula: C63H88CoN14O14P anhydrous.
Relevant uses and uses advised against (if any): Industrial Manufacturing.
SUPPLIER: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements NONE |
Signal Words: None
Hazards not otherwise classified (HNOC):
May cause mild skin irritation.
May cause mild eye irritation.
May cause mild respiratory irritation.
Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352 - IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.
3. Composition/Information on Ingredients
Product Name & Other Names: Cyanocobalamin or 5,6-Dimethylbenzimidazolyl cyanocobamide or Vitamin B12.
CAS No.: 68-19-9
EINECS EC Code: 200-680-0
4. First Aid Measures
Always seek medical advice after the first aid treatment.
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Contact medical center quickly. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Get medical attention.
5. Fire Fighting Measures
Combustible at high temperature. High heat or direct flame is necessary to cause ignition. Toxic fumes, carbon monoxide nitrogen oxides and phosphorous compounds may be formed in fire.
Explosion: At high temperature, explosive vapor-air mixtures may be formed.
Fire Extinguishing Media: Dry chemical, foam, water spray or carbon dioxide. Do not use a solid stream of water since the stream will scatter and spread the fire. Water spray may be used to keep fire exposed containers cool.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and a suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: Mop and pick up the material and place in an appropriate waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill: Avoid dust formation. Keep away from heat. Keep away from sources of ignition. Provide ventilation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Keep away from heat and source of fire. Store in cold, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not breathe dust. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing material. Storage: 2C to 8C.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: The product does not contain any relevant quantities of materials with critical values that have to be monitored at the workplace.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to the substance is apparent and engineering controls are not feasible, consult an industrial hygienist. For emergencies, or instances where the exposure levels are not known, use a full-face piece positive-pressure, air-supplied respirator. WARNING: Air purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron, or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or a full-face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. Physical and Chemical Properties
Appearance: Dark red powder or crystals.
Odor: Odorless.
Odor threshold: Not applicable.
pH: around 4.5 to 7
Melting point: > 300C.
Boiling point: Not available.
Relative density: Not available.
Flash point: Not available.
Auto-ignition temperature: > 400C.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Slightly soluble in water.
Viscosity: Not available.
Molecular Weight: 1355.37anhydrous.
Chemical Formula: C63H88CoN14O14P anhydrous.
10. Stability and Reactivity
Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, nitrogen oxides, phosphorous compounds and toxic fumes may form when heated to decomposition.
Hazardous Polymerization: Not reported. However, it can explode under certain conditions.
Incompatibilities: Oxidizing agents, bases, heat, and sparks.
Conditions to Avoid: Heat, flames, sunlight, ignition sources and incompatibles.
11. Toxicological Information
Acute toxicity:
LD50 Oral - Mouse - > 5.000 mg/kg.
Inhalation: No data available.
Dermal: No data available.
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as possible or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Teratogenic Effects: Not available.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.
12. Ecological Information
Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h.
Mobility: Likely to be mobile.
Biodegradability: Expected to be biodegradable
Results of PBT and vPvB assessment: No data available for assessment.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of containers and unused contents in accordance with federal, state, and local requirements.
14. Transport Information
DOT USA, TDG Canada & ADR/RID Europe: Not regulated
IMDG/IMO: Not regulated
IATA/ICAO: Not regulated.
15. Regulatory Information
USA:
SARA 311/312 Hazards: See section 2.
California Prop. 65 Components: This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm.
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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