Folic Acid or Folate BP Ph Eur FCC Food Grade Manufacturers, with SDS GHS MSDS Sheet |
Supplier, Manufacturer, Exporter of Folic Acid, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc. The products are offered as per required specifications and in correct shape and size in mm or meshs or microns as specified by the buyer. The participating units have one or more accreditations like FDA - cGMP and GLP approval, ISO-9001 Certified, "REACH" Registered, ISO-14001, ISO/IEC 17025, ISO-22000, FSSC 22000, ISO 45001, Kosher Certified, Halal Certified, HACCP, FSSAI. We offer Commercial Pure & IP BP EP Ph Eur USP NF JP FCC Food Grade Analytical Reagent Grades of Chemicals |
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Folic Acid or Folate: CAS Number: 59-30-3, EINECS EC Number: 200-419-0, Molecular Formula: C19H19N7O6, Molecular Weight: 441.40, HS Code ---**
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SDS MSDS Sheet of Folic Acid or Folate Manufacturers
Folic Acid
Folate BP Ph Eur FCC Food Grade Suppliers
Folic acid, also known as folate, is one of the B vitamins and has other industrial uses. Folic acid (also known as vitamin B9, vitamin Bc or folacin) and folate, as well as pteroyl-L-glutamic acid, pteroyl-L-glutamate, and pteroylmonoglutamic acid are forms of the water-soluble vitamin B9. Folic acid is itself not biologically active, but its biological importance is due to tetrahydrofolate and other derivatives after its conversion to dihydrofolic acid in the liver.
Specifications of Folic Acid:
Appearance: Faint yellow-orange to dark yellow-orange powder.
Water by KF: maximum 9%.
Sulfated ash: maximum 0.1%.
Assay: minimum 98%.
Melting point 250C literature.
Folic Acid BP Ph Eur Specifications:
C19H19N7O6 --- 441.4 CAS 59-30-3
Action and use: Vitamin B component.
DEFINITION
(2S)-2-[[4-[[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]benzoyl]amino]pentanedioic acid.
Content: 96.0 per cent to 102.0 per cent (anhydrous substance).
CHARACTERS
Appearance: Yellowish or orange, crystalline powder.
Solubility: Practically insoluble in water and in most organic solvents. It dissolves in dilute acids and in alkaline solutions.
IDENTIFICATION
First identification: A, B
Second identification: A, C
A. Specific optical rotation: + 18 to + 22 (anhydrous substance).
Dissolve 0.25 g in 0.1 M sodium hydroxide and dilute to 25.0 mL with the same solvent.
B. Examine the chromatograms obtained in the assay.
C. Thin-layer chromatography.
Related substances: To pass the test by liquid chromatography.
Water: 5.0 per cent to 8.5 per cent, determined on 0.150 g.
Sulfated ash: Maximum 0.2 per cent, determined on 1.0 g.
Folic Acid USP Grade Specifications:
C19H19N7O6 --- 441.40
l-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-;
N-[p-[[(2-Amino-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-l-glutamic acid CAS 59-30-3
DEFINITION
Folic Acid contains NLT 97.0% and NMT 102.0% of folic acid (C19H19N7O6), calculated on the anhydrous basis.
IDENTIFICATION
A. Ultraviolet Absorption:
Sample solution: 10 µg/mL in 0.1 N sodium hydroxide solution.
Acceptance criteria: Meets the requirements. The ratio A 256 / A 365 is 2.80–3.00.
Related Compounds: To pass the test.
Water Determination: NMT 8.5%
Folic Acid FCC Food Grade:
N- [4- [[(2-Amino-1,4-dihydro-4-oxo-6- pteridinyl) methyl]amino]benzoyl]-L-glutamic Acid;N-[p-[[(2-Amino-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]glutamic Acid; Pteroylglutamic Acid.
C19H19N7O6 --- Formula wt 441.40 --- CAS: [59-30-3]
DESCRIPTION
Folic Acid occurs as yellow or yellow-orange crystals or crystalline powder. About 1.6 mg dissolves in 1 mL of water. It is insoluble in acetone, in alcohol, in chloroform, and in ether, but dissolves in solutions of alkali hydroxides and carbonates. The pH of a suspension of 1 g in 10 mL of water is between 4.0 and 4.8.
Function: Nutrient.
REQUIREMENTS
Identification: The ultraviolet absorption spectrum of a 1:100,000 aqueous solution in 1:250 sodium hydroxide solution exhibits maxima and minima at the same wavelengths as those of a similar solution of USP Folic Acid Reference Standard, concomitantly measured. The ratio A256/A365 is between 2.80 and 3.00.
Assay: Not less than 95.0% and not more than 102.0% of C19H19N7O6, calculated on the anhydrous basis.
Lead: Not more than 2 mg/kg.
Residue on Ignition: Not more than 0.3%.
Water: Not more than 8.5%.
For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective eb-pages or books.
We also manufacture and supply as under:
Thiamine Hydrochloride or Vitamin B1
Methyl Folate Calcium or Calcium levomefolate or Vitamin B9 or L-Methylfolate Calcium.
Manufacturers:
MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +912223770100, +912223726950
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Folic Acid SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 21-Oct-20
1. Product Identification
Product Name & Other Names: Folic Acid or Folate.
CAS No.: 59-30-3
EINECS EC Number: 200-419-0
Molecular Weight: 441.40
Chemical Formula: C19H19N7O6
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements NONE |
Signal Word: None
Hazards not otherwise classified (HNOC):
May causes mild skin irritation.
May causes mild eye irritation.
Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352 - IF ON SKIN: Wash with plenty of soap and water.
P303+P361+P353 - IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.
3. Composition/Information on Ingredients
Product/Synonyms: Folic Acid or Folate.
CAS No.: 59-30-3
EINECS EC Number: 200-419-0
4. First Aid Measures
Always get medical attention after the first aid is over.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Wash affected areas with soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention if symptoms occur.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
5. Fire Fighting Measures
Fire: Not considered to be a fire hazard.
Explosion: Reactions with incompatibles and fine dust on heating may pose an explosion hazard.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Use means suitable for extinguishing surrounding fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. Can form products including ammonia, oxides of nitrogen, carbon oxide and toxic fumes on burning.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents and bases.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: Not established.
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is high and engineering controls are not feasible, a half face piece particulate respirator (NIOSH type N95 or better filters) may be worn for up to ten times the exposure limit or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest. A full-face piece particulate respirator (NIOSH type N100 filters) may be worn up to 50 times the exposure limit, or the maximum use concentration specified by the appropriate regulatory agency, or respirator supplier, whichever is lowest. If oil particles (e.g. lubricants, cutting fluids, glycerin, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-face piece positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres. If heat is involved, an ammonia/methylamine, dust/mist cartridge may be necessary.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection:: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. Physical and Chemical Properties
Appearance: Faint yellow-orange to dark yellow-orange powder.
Odor: Odorless.
Odor threshold: Not available.
pH: 4 to 5.
Relative density: about 1.6
Melting Point: 250C.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Not available.
Viscosity: Not available.
Molecular Weight: 441.40
Chemical Formula: C19H19N7O6.
10. Stability and Reactivity
Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: Decomposes upon heating and can form products including ammonia, oxides of nitrogen, carbon oxide and toxic fumes.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents and bases.
11. Toxicological Information
Oral rat LD50: Not available. Oral LD50 (mouse): 10 gm/kg. Intraperitoneal LD50 (mouse): 85 mg/kg. Subcutaneous LDLO (mouse): 200 mg/kg.
Carcinogenicity: Not listed by IARC, ACGIH, OSHA and NTP.
Reproductive toxicity: Not available.
Germ cell mutagenicity: Not available.
12. Ecological Information
Toxicity to fish: Not available. Avoid release into the environment.
Environmental Fate: Not available.
Results of PBT and vPvB assessment: Not available. Soluble in water Persistence is unlikely based on information available.
Mobility: Will likely be mobile in the environment due to its water solubility.
13. Disposal Considerations
Not considered a hazardous waste under Federal Hazardous Waste Regulations 40 CFR 261. Follow standard disposal procedures. Dispose of container and unused contents in accordance with legal requirements.
14. Transport Information
DOT USA & ADT/RID Europe: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods: Not dangerous goods.
15. Regulatory Information
USA Regulations:
SARA Section 302 Extremely Hazardous Substances: Not listed.
SARA Codes: Immediate.
Section 313: No chemicals are reportable under Section 313.
California Proposition 65: Not listed.
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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