Calcium Folinate BP Ph Eur Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Calcium Folinate BP Ph Eur, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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Calcium Folinate: CAS Number: 1492-18-8 (anhydrous), EINECS EC Number: yyyyy, Molecular Formula: C20H21CaN7O7-xH2O, Molecular Weight: 511.50 (anhydrous), HS Code ---**

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail prices, Uses etc available on these pages for Calcium Folinate.

Calcium Folinate BP Ph Eur Grade Specifications
Ph Eur
C20H21CaN7O7,xH2O --- 511.5 --- 1492-18-8
Action and use: Antidote to folic acid antagonists.

DEFINITION
Calcium (2S)-2-[[4-[[[(6RS)-2-amino-5-formyl-4-oxo1,4,5,6,7,8-hexahydropteridin-6-yl]methyl]amino]benzoyl]amino]pentanedioate.
Content:
calcium folinate (C20H21CaN7O7): 97.0 per cent to 102.0 per cent (anhydrous substance);
calcium (Ca; A r 40.08): 7.54 per cent to 8.14 per cent (anhydrous substance). It contains a variable amount of water.

CHARACTERS
Appearance: White or light yellow, amorphous or crystalline powder.
Solubility: Sparingly soluble in water, practically insoluble in acetone and in ethanol (96 per cent). The amorphous form may produce supersaturated solutions in water.

IDENTIFICATION
First identificationı A, B, D.
Second identificationı A, C, D.
A. Specific optical rotation.
B. Infrared absorption spectrophotometry.
C. Thin-layer chromatography.
D. It gives reaction of calcium.
Carry out the tests and the assay as rapidly as possible, protected from actinic light.

TESTS
Solution S: Dissolve 1.25 g in carbon dioxide-free water, heating at 40C if necessary, and dilute to 50.0 ml with the same solvent.
Appearance of solution: Solution S is clear and its absorbance at 420 nm is not greater than 0.60.
pH: 6.8 to 8.0 for solution S.
Specific optical rotation: + 14.4 to + 18.0 (anhydrous substance), determined on solution S.
Acetone, ethanol and methanol Limits:
acetone: maximum 0.5 per cent;
ethanol: maximum 3.0 per cent;
methanol: maximum 0.5 per cent.
Related substances: To pass the test,
Chlorides: Maximum 0.5 per cent.
Heavy metals: Maximum 50 ppm.
Platinum: Maximum 20.0 ppm.
Water: Maximum 17.0 per cent, determined on 0.200 g (ground to a very fine powder ).
Bacterial endotoxins: Less than 0.5 IU/mg, if intended for use in the manufacture of parenteral dosage forms without a further appropriate procedure for the removal of bacterial endotoxins.

STORAGE
In an airtight container, protected from light. If the substance is sterile, store in a sterile, airtight, tamper-proof container .

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

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Calcium Folinate SDS, SAFETY DATA SHEET
MSDS Sheet, MATERIAL SAFETY DATA SHEET 05-Oct-20

Product Name & Other Names: Calcium Folinate
CAS Number: 1492-18-8 (anhydrous)
Molecular Formula: C20H21CaN7O7-xH2O
Molecular Weight: 511.50
Relevant uses and uses advised against (if any): Laboratory and Industrial Manufacturing.
SUPPLIER: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Skin corrosion/irritation Category 2, H315
Sensitization, Skin Category 1, H317
Serious eye damage/eye irritation Category 2A, H319
Sensitization, respiratory Category 1, H334
Specific target organ toxicity, single exposure; Respiratory tract irritation Category 3, H335

Hazard Statements:
H315: Causes skin irritation.
H317: May cause an allergic skin reaction.
H319: Causes serious eye irritation.
H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H335: May cause respiratory irritation.

Precautionary Statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P264: Wash … thoroughly after handling.
P272: Contaminated work clothing should not be allowed out of the workplace.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+352: IF ON SKIN: Wash with soap and water.
P332+313: If skin irritation occurs: Get medical advice/attention.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
P333+313: If skin irritation or a rash occurs: Get medical advice/attention.
P337+313: If eye irritation persists get medical advice/attention.
P362: Take off contaminated clothing and wash before reuse.
P391: Collect spillage.
P501: Dispose of contents/container in accordance with local/national regulation.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
Xi Irritant
Risk Phrase:
R36/37/38: Irritating to eyes, respiratory system, and skin.
R43 May cause sensitization by skin contact.

Eye Contact: Rinse immediately with plenty of water for 10 minutes at least. Contact a physician if symptoms persist.
Skin Contact: Wash thoroughly with soap and water; flush with plenty of water. Take off spoilt clothes. Contact physician if symptoms persist.
Ingestion: Wash the mouth with water; seek medical advice immediately.
Inhalation: Remove from exposure site to fresh air and keep at rest. Obtain medical advice.

Extinguishing Media Recommended: Water spray, CO2, foam, dry chemicals. Use an extinguishing agent suitable for the surrounding fire.
Non-Recommended: Do not use direct water jet on burning material.
Extinguishing Procedure: Closed containers may build up pressure at elevated temperatures. If possible, containers should be cooled with a water spray.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law. Avoid open flames or other sources of ignition.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents, strong acids, alkali. Keep away from ignition sources and naked flame.

Respiratory Protection: Avoid to breath directly on the product. Apply local ventilations when appropriate.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: Light yellow crystalline powder
Odor: Odorless.
Odor threshold: Not available.
pH: 6.8 - 8.0 at 25 g/l
Relative density: around 1.01
Melting point/freezing point: Not available.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition Temperature: 240C - 250C
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Soluble in water.
Viscosity: Not available.

Reactivity: It presents no significant reactivity hazards, by itself or in contact with water. Avoid contact with strong acids, alkali, or oxidizing agents.
Decomposition: Carbon monoxide Carbon oxides, Nitrogen oxides (NOx), Calcium oxide and toxic unidentified organic compounds may be formed during combustion.

LD 50 ORAL/RAT (mg/Kg): 8000
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as possible or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Teratogenic Effects: Not available.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.

Toxicity to fish: No data available
Results of PBT and vPvB assessment: This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Precautions: Prevent contamination of soil, ground and surface water.

In accordance with local environmental laws. Avoid disposing into drainage systems and into the environment.

DOT USA: Not regulated as dangerous goods.
ADR/RID Europe: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods.

USA:
SARA 302: No Data available.
SARA 313: No Data available.
SARA 311/312 Hazards: Acute Health Hazard.
California Prop 65 Components: This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.

European Labeling in Accordance with EC Directives:
H315: Causes skin irritation.
H317: May cause an allergic skin reaction.
H319: Causes serious eye irritation.
H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H335: May cause respiratory irritation.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
Xi Irritant
Risk Phrase:
R36/37/38 Irritating to eyes, respiratory system, and skin.
R43 May cause sensitization by skin contact.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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