Streptomycin Sulfate or Streptomycin Sulphate USP BP Ph Eur Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Streptomycin Sulfate or Streptomycin Sulphate, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal etc.

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Streptomycin Sulfate or Streptomycin Sulphate CAS Number 3810-74-0, EINECS EC Number: 223-286-0, Molecular Formula: (C21H39N7O12)2-3H2SO4, Molecular Weight: 1457.38, HS Code 29412010

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Streptomycin Sulfate or Streptomycin Sulphate.

Streptomycin sulfate is an aminocyclitol glycoside antibiotic which interferes with protein synthesis in prokaryotes. This antibiotic is effective against both gram-positive and gram-negative bacteria and is frequently used in cell culture media.

General Properties and Specifications of Streptomycin Sulfate or Streptomycin Sulphate:
Appearance: White to off - white Crystalline powder.
Odor: Faint amine-like odor.
Solubility of 20% aq. solution: Clear, pale yellow.
pH: 4.5 - 7.0 20% aq. solution.
Potency: 720 unit/mg minimum.
Identification Test: Passes test.
Solubility: Soluble in water.
Storage: 2C to 8C (Refrigerate).

Streptomycin Sulfate USP Grade Specifications:
(C21H39N7O12)2-3H2SO4 --- 1457.38
d-Streptamine, O-2-deoxy-2-(methylamino)-α-l-glucopyranosyl-(1→2)-O-5-deoxy-3-C-formyl-α-l-lyxofuranosyl-(1→4)-N,N ′-bis(aminoiminomethyl)-, sulfate (2:3) (salt).
Streptomycin sulfate (2:3) (salt) CAS 3810-74-0
UNII: CW25IKJ202
UNII: Y45QSO73OB

Streptomycin Sulfate has a potency equivalent to not less than 650 µg and not more than 850 µg of streptomycin (C21H39N7O12) per mg.

Identification:
A: Dissolve 5 g of ferric chloride in 50 mL of 0.1 N hydrochloric acid. Transfer 2.5 mL of this stock solution to a 100-mL volumetric flask, dilute with 0.01 N hydrochloric acid to volume, and mix. Prepare Iron reagent at the time of use. Dissolve the specimen in water and dilute with water to obtain a solution containing about 1 mg of streptomycin per mL. To 5 mL of this solution add 2.0 mL of 1 N sodium hydroxide, and heat in a water bath for 10 minutes. Cool in ice water for 3 minutes, then add 2.0 mL of 1.2 N hydrochloric acid, and mix. Add 5 mL of Iron reagent, and mix: a violet color is produced.
B: It responds to the tests for Sulfate.

pH: between 4.5 and 7.0, in a solution containing 200 mg of streptomycin per mL.
Loss on drying: Dry about 100 mg, accurately weighed, in a capillary-stoppered bottle in vacuum at a pressure not exceeding 5 mm of mercury at 60C for 3 hours: it loses not more than 5.0% of its weight.

DEFINITION
Streptomycin sulfate is bis[N,N′-bis(aminoiminomethyl)-4-O-[5-deoxy-2-O-[2-deoxy-2-(methylamino)-α-L-glucopyranosyl]-3-C-formyl-α-L-lyxofuranosyl]-D-streptamine] trisulfate, a substance produced by the growth of certain strains of Streptomyces griseus or obtained by any other means. Stabilisers may be added. The potency is not less than 720 IU/mg, calculated with reference to the dried substance.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +912223770100, +912223726950
Current Date Time in India GMT+5:30

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Call toll-free 1-877-682-9243 (1-877-MUBYCHEM)

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Streptomycin Sulfate or Streptomycin Sulphate SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 13-Dec-23

Product Name & Other Names: Streptomycin Sulfate or Streptomycin Sulphate
CAS Number: 3810-74-0
EINECS EC Number: 223-286-0
Molecular Weight: 1457.38
Chemical Formula: (C21H39N7O12)2-3H2SO4
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Hazard Statements:
H302: Harmful if swallowed.
H361: Suspected of damaging fertility or the unborn child.

Precautionary Statements:
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash contaminated parts thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310: IF SWALLOWED: Immediately call a POSION CENTER or doctor/physician.
P314: Get medical advice/attention if you feel unwell.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P302+352: IF ON SKIN: Wash with plenty of soap and water.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
P308 + P313: IF exposed or concerned: Get medical advice/ attention.
P360: Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P403 P404: Store in well-ventilated place. Keep container tightly closed.
P501: Dispose of contents/container in accordance with local/national regulation.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbols:
Xn Harmful.
Xi Irritant.
Risk Phrases:
R22 Harmful if swallowed.
R60 May impair fertility.
R61 May cause harm to the unborn child.

Product Name & Other Names: Streptomycin Sulfate or Streptomycin Sulphate
CAS Number: 3810-74-0
EINECS EC Number: 223-286-0

Inhalation: Remove affected person to fresh air; if normal breathing has not returned within a few minutes after exposure, get medical attention.
Skin: Remove contaminated clothing; wash affected area with soap and water; launder contaminated clothing before reuse. Seek medical attention.
Eyes: Immediately, flush eyes for 15 minutes in clear running water while holding eyelids open; seek medical attention immediately.
Ingestion: Drink two glasses of water followed by milk, milk of magnesia or other non-alcoholic liquids; Do not induce vomiting; seek medical attention immediately.
Physician may treat symptomatically.

General Hazards: Product will support combustion.
Extinguishing Media: Carbon dioxide, water fog, dry chemical, chemical foam. Keep containers cool by spraying with water. Use extinguishing media appropriate for surrounding fire.
Fire & Explosion Hazard: May evolve oxides of carbon (COx), nitrogen oxides, sulfur oxides and fumes under fire conditions.
In case of fire, wear a full face positive-pressure self-contained breathing apparatus and protective suit. Self - contained respiratory equipment; cool containers to prevent pressure buildup and explosion when exposed to extreme heat. Caution - material will support combustion!
Unusual Fire and Explosion Hazards: Closed containers can explode due to buildup of pressure when exposed to extreme heat.
Hazardous Combustion Products: Products of combustion include nitrogen oxides, sulfur oxides, CO, CO2 and toxic fumes.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and a suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter sewer, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Contain spilled material. Vacuum or sweep up and remove to an approved disposal container.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Keep containers closed when not in use; protect containers from abuse; protect from extreme temperatures, open flames. This material will support combustion. Storage: 2C to 8C (Refrigerate).

Engineering Controls: The use of local exhaust ventilation is recommended to control emissions near the source. Provide mechanical ventilation of confined spaces. Use corrosion-resistant, explosion-proof ventilation equipment.
Exposure Limits: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: White to off - white Crystalline powder.
Odor: Faint amine-like odor.
Odor threshold: Not available.
pH: 4.5 - 7.0 20% aq. solution.
Relative density: Not available.
Melting point/freezing point: Not available.
Boiling Point: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor Pressure (MM Hg): Not available.
Vapor Density (Air = 1): Not available.
Evaporation Rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility in Water: Soluble.
Viscosity: Not available.
Molecular Weight: 1457.38
Chemical Formula: (C21H39N7O12)2-3H2SO4

Stability: Stable at recommended temperatures and operating conditions.
Conditions to Avoid: Avoid excessively high temperatures, sunlight, air, and incompatibles.
Incompatibilities: Strong oxidizing agents.
Decomposition: Decomposition yields nitrogen oxides, sulfur oxides, carbon monoxide & dioxide, fumes.
Polymerization: Polymerization will not occur.

Reproduction: Suspected of damaging the unborn child. Suspected of damaging fertility.
Mutagenicity: Not mutagenic in AMES Test or via micronucleus test on mice.
Carcinogenicity: Not listed as a human carcinogen by OSHA, IARC, ACGIH & NTP.
Acute Oral Effects: Oral LD50 – Rats 430 mg/kg.
Acute Dermal Toxicity: LD50 Dermal - Rat - 3129 mg/kg.

Toxicity to fresh-water fish: LC50 - Oncorhynchus mykiss (rainbow trout) - > 180 mg/l - 96 h.
Toxicity to daphnia and other aquatic invertebrates: EC50 - Ceriodaphnia (water flea) - 487 mg/l - 48 h.
Persistence and accumulation: Bioaccumulation is unlikely.
Mobility: Will be mobile in the environment due to its water solubility.

Dispose in accordance with Local, State, and Federal Regulations. Consult local, state, or Federal Environmental Protection Agency before disposing of any chemicals.

DOT USA, TDG Canada & ADR/RID Europe: Not regulated.
IMDG/IMO & IATA/ICAO: Not regulated.

UNITED STATES REGULATORY INFORMATION
SARA 311/312 Hazard Categories: See section 2 for more information
California Prop 65: Not listed.

European Labeling in Accordance with EC Directives:
H302: Harmful if swallowed.
H361: Suspected of damaging fertility or the unborn child.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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