Nebivolol Hydrochloride or Narbivolol or Nebilet IP BP EP Ph Eur USP Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Nebivolol Hydrochloride or Narbivolol or Nebilet, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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Nebivolol Hydrochloride or Narbivolol or Nebilet CAS Number 152520-56-4 (also 169293-50-9), EINECS EC Number: 690-990-6, Molecular Formula: C22H25F2NO4-HCl, Molecular Weight: 441.9, HS Code 29322090

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SDS MSDS Sheet of Nebivolol Hydrochloride or Narbivolol or Nebilet Manufacturers

Nebivolol Hydrochloride
Narbivolol or Nebilet IP BP EP Ph Eur USP Suppliers
Nebivolol Hydrochloride

Nebivolol is used to treat high blood pressure (hypertension). Nebivolol is a beta-blocker.

General Properties and Specifications of Nebivolol Hydrochloride or Narbivolol, or Nebilet:
Appearance: White to off-white powder.
Assay: Between 98% and 102%
Identifications: By comparison with standard. IR and HPLC.
Solubility: Soluble in water. Sparingly soluble in Dimethylformamide and slightly soluble in Methanol.
Related substance impurity: Single impurity >0.5% and total impurity >1%
Heavy metals: >20 ppm.
Sulfated ash: >0.2%
Residual solvent:
Methanol: >3000 ppm.
Acetonitrile: >410 ppm.
Isopropyl alcohol: >5000 ppm.
Diisopropyl ether: >1000 ppm.
Water by KF: >1%
Melting point: 219C to 222C.
Storage: 2C to 8C Refrigerate. OK to freeze. Shipping may be at room temperature. Protect from light.

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We also manufacture and supply as under:

Nebivolol Hydrochloride or Narbivolol or Nebilet

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Manufacturers:

MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
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Last 16 June, 2024

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Nebivolol Hydrochloride or Narbivolol, or Nebilet SDS Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet
18-Jan-23

1. Product Identification

Product Name & Other Names: Nebivolol Hydrochloride or Narbivolol, or Nebilet.
CAS No.: 152520-56-4 (also 169293-50-9)
EINECS EC Code: 690-990-6
Molecular Weight: 139.63
Chemical Formula: C22H25F2NO4-HCl
Relevant uses and uses advised against (if any): Industrial Manufacturing.
SUPPLIER: AS per letterhead.

2. Hazards Identification

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Labeling according to GHS & Regulation (EC) No 1272/2008

GHS Label Elements
None

Signal Words: None

Hazards not otherwise classified (HNOC):
May cause harm if swallowed.
May causes mild skin irritation.
May causes mild eye irritation.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

3. COMPOSITION/INFORMATION ON INGREDIENTS

Product Name & Other Names: Nebivolol Hydrochloride or Narbivolol, or Nebilet.
CAS No.: 152520-56-4 (also 169293-50-9)
EINECS EC Code: 690-990-6

4. FIRST AID MEASURES

Always get medical attention after the first aid is over.

Emergency and First Aid Procedures:
Eyes - Flush with water for at least 15 minutes, raising and lowering eyelids occasionally. Get medical attention if irritation persists.
Skin - Thoroughly wash exposed area for at least 15 minutes. Remove contaminated clothing. Launder contaminated clothing before reuse. Get medical attention if irritation persists.
Ingestion - If swallowed, if conscious, give plenty of water. Immediately call a physician.
Inhalation - Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Keep a person warm, quiet, and get medical attention.

5. FIREFIGHTING PROCEDURES

Extinguisher Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Avoid solid water jet as it can spread fire.
Special Firefighting Procedures: Firefighters should wear full protective equipment and NIOSH approved self-contained breathing apparatus.
Unusual Fire and Explosion Hazards: Heated to decomposition, however, toxic oxides of sulfur, chlorine compounds, oxides of nitrogen and oxides of carbon along with fumes may be evolved.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes.

6. SPILL OR LEAK PROCEDURES

Personal precautions, protective equipment, and emergency procedures: Ventilate area of spill. Avoid creating dust. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container.

7. SPECIAL PRECAUTIONS

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Provide appropriate exhaust ventilation at places where dust is formed. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like Strong oxidizing agents, Strong bases. Storage: 2C to 8C Refrigerate. OK to freeze. Shipping may be at room temperature. Protect from light.

8. SPECIAL PROTECTION INFORMATION

Exposure limits: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Respiratory Protection (Specify Type): None needed under normal conditions of use with adequate ventilation. NIOSH approved equipment should be worn if PELs are exceeded.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

9. PHYSICAL DATA

Physical State: White to off-white powder.
Odor: Not available.
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Melting Point: 219C to 222C.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility in Water: Not available.
Viscosity: Not available.
Molecular Weight: 139.63
Chemical Formula: C22H25F2NO4-HCl

10. REACTIVITY DATA

Stability: Stable.
Conditions to Avoid: Dust generation, Incompatibles
Incompatibility (Materials to Avoid): Strong oxidizing agents, Strong bases.
Hazardous Decomposition Products: Compounds of fluorine, chlorine compounds, nitrogen, and carbon oxides along with fumes.
Hazardous Polymerization: Will not occur.

11. TOXICITY DATA

Toxicity Data: Not available.
Carcinogenicity: Not listed as carcinogen by IARC, ACGIH, OSHA and NTP.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.

12. ECOLOGICAL DATA

Toxicity to fish, daphnia, and other aquatic invertebrates: No data available.
Persistence and Degradability: Not available.
Mobility: Not available.
Results of PBT and vPvB assessment: No data available for assessment.

13. DISPOSAL INFORMATION
Waste Disposal Methods: Dispose in accordance with all applicable regulations.

14. TRANSPORT INFORMATION

DOT (USA) & ADT/RID Europe: Not dangerous goods.
IMDG & IATA: Not dangerous goods.

15. REGULATORY INFORMATION

USA Regulations:
SARA 311/312 Hazard Categories: See section 2 for more information.

16. ADDITIONAL INFORMATION

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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