Metoprolol Succinate IP BP Ph Eur EP USP Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Metoprolol Succinate IP BP Ph Eur EP USP Grade, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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Metoprolol Succinate CAS Number 98418-47-4 or 123245-49-8, EINECS EC Number: 620-476-9, Molecular Formula: C34H56N2O10, Molecular Weight: 652.82, HS Code 30049099 or 29420090 or 29420090

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Metoprolol Succinate.

Metoprolol Succinate is a beta-blocker used to treat chest pain, heart failure, and high blood pressure. Metoprolol Succinate. Metoprolol Succinate is a long-acting beta blocker that works specifically on the heart. It works by slowing down the heart rate and makes the heart more efficient at pumping blood around the body. Metoprolol succinate is a white crystalline powder with a molecular weight of 652.8. It is freely soluble in water; soluble in methanol; sparingly soluble in ethanol.

General Properties and Specifications of Metoprolol Succinate:
Appearance: White or almost white, crystalline powder.
Assay: 985 minimum.
Melting Point: 142C to 148C.
Boiling Point: 399C.
Solubility: It is freely soluble in water; soluble in methanol; sparingly soluble in ethanol.
Storage: Store at 4C in tightly closed containers, protected from light.

Metoprolol Succinate USP Grade Specifications:
(C15H25NO3)2-C4H6O4 --- 652.82
2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (±)-, butanedioate (2:1) (salt).
(±)-1-(Isopropylamino)-3-[p-(2-methoxyethyl)phenoxy]-2-propanol succinate (2:1) (salt) CAS 98418-47-4.
UNII: TH25PD4CCB
UNII: GEB06NHM23

Metoprolol Succinate contains not less than 98.0 percent and not more than 102.0 percent of (C15H25NO3)2-C4H6O4, calculated on the dried basis.

Clarity and color of solution: A solution of Metoprolol Succinate having a concentration of 20 mg per mL is not less clear than an equal volume of water in a test tube of similar size. The absorbance of the solution determined at 440 nm in a 5-cm cell, using water as the blank, is not more than 0.1.
Identification: Infrared Absorption.
pH: between 7.0 and 7.6, in a solution containing 65 mg per mL.
Loss on drying: Dry it in vacuum at 60C for 4 hours: it loses not more than 0.2% of its weight.
Residue on ignition: not more than 0.1%.
Related compounds: To pass the test.

DEFINITION
Bis[(2RS)-1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]propan-2-ol] butanedioate.
Content: 99.0 per cent to 101.0 per cent (dried substance).

CHARACTERS
Appearance: White or almost white, crystalline powder.
Solubility: Freely soluble in water, soluble in methanol, slightly soluble in ethanol (96 per cent), very slightly soluble in ethyl acetate.

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Metoprolol Succinate SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 07-Feb-24

Product Name & Other Names: Metoprolol Succinate.
CAS No.: 98418-47-4 or 123245-49-8
EINECS, EC Number: 620-476-9
Molecular Weight: 652.82
Molecular Formula: C34H56N2O10
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Supplier: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Skin corrosion/irritation Category 2, H315
Serious eye damage/eye irritation Category 2A, H319
Specific target organ toxicity, single exposure; Respiratory tract irritation Category 3, H335
Specific target organ toxicity - single exposure, Category 1, H370

Hazard statements:
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
H370: Causes damage to organs.

Precautionary statements:
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash skin thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352-IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
P332+313: If skin irritation occurs: Get medical advice/attention.
P337+P313: If eye irritation persists: Get medical advice/ attention.
P362: Take off contaminated clothing and wash before reuse.
P501: Dispose of contents/container in accordance with local/regional/national/international regulations.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
Xi Irritant
Risk Phrases:
R36/37/38 Irritating to eyes, respiratory system, and skin.
R48 Danger of serious damage to health by prolonged exposure.

Product Name & Other Names: Metoprolol Succinate.
CAS No.: 98418-47-4 or 123245-49-8
EINECS, EC Number: 620-476-9

Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

Flammability of the Product: Combustible at high temperature.
Products of Combustion: Nitrogen oxides, Carbon dioxide, Carbon monoxide, fumes.
Fire: Flammable in the presence of open flame.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Avoid heavy water jet. Use any means suitable for extinguishing surrounding fire.
Special Information: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place. In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation. Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.

7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Storage: Store at 4C in tightly closed containers, protected from light.

Airborne Exposure Limits: Not Established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: White or almost white, crystalline powder.
Odor: Not available.
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Melting Point: 142C to 148C.
Initial boiling point and boiling range: 399C.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: It is freely soluble in water; soluble in methanol; sparingly soluble in ethanol.
Viscosity: Not available.
Molecular Weight: 652.82
Molecular Formula: C34H56N2O10

Stability: Stable under recommended conditions of use and storage.
Hazardous Decomposition Products: It emits Oxides of Nitrogen, Carbon dioxide, Carbon monoxide & Fumes.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents.
Conditions to Avoid: Incompatibles, heat & direct sunlight.

Toxicity data: Not available.
Carcinogenic Effects: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible, or confirmed human carcinogen by IARC.
Reproductive toxicity: Not available.
Germ cell mutagenicity: Not available.
Danger of serious damage to health by prolonged exposure.

Environmental Fate: Not available.
Environmental Toxicity: Not available.
Persistence and degradability: Unlikely to persist due to water solubility.
Bioaccumulative potential: Not available.
Mobility in soil: Likely to be mobile due to water solubility.
Results of PBT and vPvB assessment: Not available.

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of containers and unused contents in accordance with federal, state, and local requirements.

DOT USA, TDG Canada & ADR/RID Europe: Not regulated.
IATA: Not regulated.
IMDG/IMO: Not regulated.

USA:
SARA 311/312 Hazards: Immediate Health Hazard. See section 2.
California prop. 65: Contains no chemical subject to California Prop 65.

European Labeling in Accordance with EC Directives:
H315 = Causes skin irritation.
H319 = Causes serious eye irritation.
H335 = May cause respiratory irritation.
H370: Causes damage to organs.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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