Dexpanthenol or D-Panthenol or D-Pantothenyl Alcohol or Pantothenol USP BP Ph Eur FCC Food Grade Manufacturers, with SDS GHS MSDS Sheet |
Supplier, Manufacturer, Exporter of Dexpanthenol or D-Panthenol or D-Pantothenyl Alcohol or Pantothenol USP BP Ph Eur FCC Food Grade, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy Portugal, Bangladesh, etc. The products are offered as per required specifications and in correct shape and size in mm or meshs or microns as specified by the buyer. The participating units have one or more accreditations like FDA - cGMP and GLP approval, ISO-9001 Certified, "REACH" Registered, ISO-14001, ISO/IEC 17025, ISO-22000, FSSC 22000, ISO 45001, Kosher Certified, Halal Certified, HACCP, FSSAI. We offer Commercial Pure & IP BP EP Ph Eur USP NF JP FCC Food Grade Analytical Reagent Grades of Chemicals |
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Dexpanthenol or D-Panthenol or D-Pantothenyl Alcohol or Pantothenol CAS Number 81-13-0 or 16485-10-2, EINECS EC Number: 201-327-3 or 240-540-6, Molecular Formula: C9H19NO4, Molecular Weight: 205.25, HS Code 29362401 or 29241990 or 29362990
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SDS MSDS Sheet of Dexpanthenol or D-Panthenol or D-Pantothenyl Alcohol or Pantothenol Manufacturers
Dexpanthenol
D-Panthenol or D-Pantothenyl Alcohol or Pantothenol Suppliers
Dexpanthenol or D-Panthenol or D-Pantothenyl Alcohol or Pantothenol is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations. It is also used in nutritional supplements
Dexpanthenol BP Ph Eur Grade Specifications:
C9H19NO4 --- 205.3 --- 81-13-0
Action and use: Vitamin B5 analogue.
DEFINITION
Dexpanthenol contains not less than 98.0 per cent and not more than the equivalent of 101.0 per cent of (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide, calculated with reference to the anhydrous substance.
CHARACTERS
A colourless or slightly yellowish, viscous hygroscopic liquid, or a white or almost white, crystalline powder, very soluble in water, freely soluble in ethanol (96 per cent).
IDENTIFICATION
First identification: A, B
Second identification: A, C, D
A. Specific optical rotation.
B. Examine by infrared absorption spectrophotometry.
C. Examine the chromatograms obtained in the test for 3-aminopropanol. The principal spot in the chromatogram obtained with test solution is similar in position, colour and size to the principal spot in the chromatogram obtained with reference solution.
D. To 1 mL of solution S (see Tests) add 1 mL of dilute sodium hydroxide solution and 0.1 Ml of copper sulfate solution. A blue colour develops.
TESTS
Solution S: Dissolve 2.500 g in carbon dioxide-free water and dilute to 50.0 mL with the same solvent.
Appearance of solution: Solution S is clear and not more intensely coloured than reference solution.
pH: The pH of solution S is not greater than 10.5.
Specific optical rotation: The specific optical rotation is + 29.0 to + 32.0, determined on solution S and calculated with reference to the anhydrous substance.
3-Aminopropanol: To pass the test by thin-layer chromatography.
Water: Not more than 1.0 per cent, determined on 1.000 g.
Sulfated ash: Not more than 0.1 per cent, determined on 1.0 g.
Storage: In an airtight container.
Dexpanthenol USP Grade Specifications:
C9H19NO4 --- 205.25
Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (R)-;
d-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide
CAS 81-13-0
UNII: 1O6C93RI7Z
DEFINITION
Dexpanthenol contains NLT 98.0% and NMT 102.0% of dexpanthanol (C9H19NO4), calculated on the anhydrous basis.
IDENTIFICATION
A. Infrared Absorption
B.
Sample solution: 100 mg/mL of Dexpanthenol.
Analysis: To 1 mL of the Sample solution add 5 mL of 1 N sodium hydroxide and 1 drop of cupric sulfate and shake vigorously.
Acceptance criteria: A deep blue color develops.
C.
Sample solution: 10 mg/mL of Dexpanthenol.
Analysis: To 1 mL of the Sample solution add 1 mL of 1 N hydrochloric acid, and heat on a steam bath for 30 min. Cool, add 100 mg of hydroxylamine hydrochloride, and add 5 mL of 1 N sodium hydroxide. Allow to stand for 5 min, then adjust with 1 N hydrochloric acid to a pH of 2.5 to 3.0 and add 1 drop of ferric chloride.
Acceptance criteria: A purplish red color develops.
Residue on Ignition: NMT 0.1%
Limit of Aminopropanol: To pass the test.
Optical Rotation, Specific Rotation:
Sample solution: 50 mg/mL in water.
Acceptance criteria: +29.0° to +31.5°
Refractive Index: 1.495–1.502, at 20C
Water Determination: NMT 1.0%
Packaging and Storage: Preserve in tight containers.
Dexpanthenol FCC Food Grade Specifications:
D(+)-Pantothenyl Alcohol; Panthenol
C9H19NO4 Formula weight 205.25
CAS 81-13-0
DESCRIPTION
Dexpanthenol occurs as a clear, viscous, somewhat hygroscopic liquid. It is the dextrorotatory isomer of the alcohol analogue of pantothenic acid. Some crystallization may occur on standing. It is freely soluble in water, in alcohol, in methanol and in propylene glycol. It is soluble in chloroform and in ether and is slightly soluble in glycerin. Its solutions are alkaline to litmus.
Function: Nutrient.
REQUIREMENTS
Identification:
A. Add 5 mL of 1 N sodium hydroxide and 1 drop of cupric sulfate to 1 mL of a 10% aqueous solution and shake vigorously. Deep-blue color develops.
B. Add 1 mL of 1 N hydrochloric acid to 1 mL of a 1% aqueous solution, and heat on a steam bath for about 30 minutes. Cool, add 100 mg of hydroxylamine hydrochloride, mix, and add 5 mL of 1 N sodium hydroxide. Allow it to stand for 5minutes, then adjust the pH to within a range of 2.5 to 3.0 with 1 N hydrochloric acid and add 1 drop of ferric chloride. A purple-red color develops.
C. The infrared absorption spectrum of a film of the sample exhibits maxima only at the same wavelengths as those of a similar preparation of USP Dexpanthenol Reference Standard.
Assay: Not less than 98.0% and not more than 102.0% of C9H19NO4, calculated on the anhydrous basis.
Aminopropanol: Not more than 1%.
Lead: Not more than 5 mg/kg.
Optical (Specific) Rotation [α]D25°: Between +29.0° and +31.5°.
Refractive Index: Between 1.495 and 1.502 at 20°.
Residue on Ignition: Not more than 0.1%.
Water: Not more than 1%.
For Original Monographs of IP Indian Pharmacopoeia EP Ph Eur European Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.
We also manufacture and supply as under:
Dexpanthenol or D-Panthenol or D-Pantothenyl Alcohol or Pantothenol
Phenethyl Alcohol, 2-Phenyl Ethanol.
Manufacturers:
MUBY CHEMICALS
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Last
21 October, 2024
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Dexpanthenol or D-Panthenol or D-Pantothenyl Alcohol or Pantothenol
SDS Sheet, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 21-Oct-24
1. Product Identification
Product Name & Other Names: Dexpanthenol or D-Panthenol or D-Pantothenyl Alcohol or Pantothenol.
CAS No.: 81-13-0 or 16485-10-2
EINECS EC Code: 201-327-3 or 240-540-6
Molecular Weight: 205.25
Chemical Formula: C9H19NO4
Relevant uses and uses advised against (if any): Industrial Manufacturing.
SUPPLIER: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements NONE |
Signal Words: None
Hazards not otherwise classified (HNOC):
May cause mild skin irritation.
May cause mild eye irritation.
May cause mild respiratory irritation.
Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a comfortable position for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.
3. Composition/Information on Ingredients
Product Name & Other Names: Dexpanthenol or D-Panthenol or D-Pantothenyl Alcohol or Pantothenol.
CAS No.: 81-13-0 or 16485-10-2
EINECS EC Code: 201-327-3 or 240-540-6
4. First Aid Measures
Always seek medical advice after the first aid treatment.
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Contact the medical center quickly. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reusing. Thoroughly clean shoes before reuse.
Eye Contact: Check for and remove any contact lenses. Immediately flush your eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Get medical attention.
5. Fire Fighting Measures
Combustible at high temperature. High heat or direct flame is necessary to cause ignition. Toxic fumes, carbon monoxide and nitrogen oxides may be formed in fire.
Explosion: at high temperature, explosive vapor-air mixtures may be formed.
Fire Extinguishing Media: Dry chemical, foam, water spray or carbon dioxide. Do not use a solid stream of water since the stream will scatter and spread the fire. Water spray may be used to keep fire exposed containers cool.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and a suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved people should evacuate to a safe place.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: Mop and pick up the material and place it in an appropriate waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill: Avoid dust formation. Keep away from heat. Keep away from sources of ignition. Provide ventilation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove it into an approved disposal container.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling it. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep the container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Keep away from heat and source of fire. Store in cold, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original containers. Keep air contact to a minimum. Do not breathe dust. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing material. Prevent any electrostatic discharge. Storage: Room temperature. Recommended in a cool and dark place, <15C.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to the substance is apparent and engineering controls are not feasible, consult an industrial hygienist. For emergencies, or instances where the exposure levels are not known, use a full-face piece positive-pressure, air-supplied respirator. WARNING: Air purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or a full-face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. Physical and Chemical Properties
Appearance: Viscous liquid or white to almost white solid. Hygroscopic.
Odor: Not available.
Odor threshold: Not available.
pH: about 9.5
Relative density: about 1.2
Melting Point: around 25C.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Freely soluble in water. Soluble in methanol and alcohol.
Viscosity: Not available.
Molecular Weight: 205.25
Chemical Formula: C9H19NO4
10. Stability and Reactivity
Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, nitrogen oxides and toxic fumes may form when heated to decomposition.
Hazardous Polymerization: Not reported. However, it can explode under certain conditions.
Incompatibilities: Oxidizing agents, heat, and sparks.
Conditions to Avoid: Heat, flames, sunlight, ignition sources, moisture, and incompatibles.
11. Toxicological Information
Toxicity: LD50 Oral Mouse: >10000 mg/kg.
Mutagenic Effects: No information available.
Reproductive Effects: No information available.
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible, or confirmed human carcinogen by IARC, ACGIH, OSGHA or NTP.
12. Ecological Information
Toxicity to fish: Not available.
Biodegradability: Not available.
Mobility in soil: Not available.
Results of PBT and vPvB assessment: Not available.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of containers and unused contents in accordance with law.
14. Transport Information
DOT USA, TDG Canada & ADR/RID Europe: Not regulated.
IMDG/IMO: Not regulated.
IATA: Not regulated.
15. Regulatory Information
USA:
SARA 311/312 Hazards: No.
California Prop. 65 Components: This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm.
16. Other Information
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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