Calcium pantothenate or Calcium D-pantothenate USP BP EP Ph Eur IP FCC Food Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Calcium pantothenate or Calcium D-pantothenate USP BP EP Ph Eur IP FCC Food Grade, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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Calcium pantothenate or Calcium D-pantothenate: CAS Number: 137-08-6, EINECS EC Number: 205-278-9, Molecular Formula: C18H32CaN2O10, Molecular Weight: 476.5, HS Code 29362400

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail prices, Uses etc available on these pages for Calcium pantothenate or Calcium D-pantothenate.

Pantothenic acid, also called vitamin B5 (a B vitamin), is a water-soluble vitamin. Pantothenic acid is an essential nutrient. Calcium Pantothenate or D-calcium pantothenate is the calcium salt of the water-soluble vitamin B5, ubiquitously found in plants and animal tissues with antioxidant property. Calcium Pantothenate is the calcium salt of pantothenic acid and is used in a combination with other vitamins to treat vitamin deficiency conditions.

Calcium Pantothenate USP Grade
C18H32CaN2O10 --- 476.53
-Alanine, N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-, calcium salt (2:1), (R)-.
Calcium D-pantothenate (1:2) --- CAS 137-08-6

Calcium Pantothenate is the calcium salt of the dextrorotatory isomer of pantothenic acid. It contains not less than 5.7 percent and not more than 6.0 percent of nitrogen (N), and not less than 8.2 percent and not more than 8.6 percent of calcium (Ca), both calculated on the dried basis.

Packaging and storage: Preserve in tight containers.
Identification:
A: Infrared Absorption.
B: A solution (1 in 20) responds to the tests for Calcium.
Specific rotation: between +25.0 and +27.5 .
Test solution: 50 mg per mL, in water.
Alkalinity: Dissolve 1.0 g in 15 mL of carbon dioxide-free water in a small flask. As soon as solution is complete, add 1.0 mL of 0.10 N hydrochloric acid, then add 0.05 mL of phenolphthalein, and mix: no pink color is produced within 5 seconds.
Loss on drying: Dry it at 105C for 3 hours: it loses not more than 5.0% of its weight.
Heavy metals: ---: the limit is 0.002%.
Nitrogen content: To pass the test.
Content of calcium: Dissolve about 800 mg of Calcium Pantothenate, accurately weighed, in 150 mL of water containing 2 mL of 3 N hydrochloric acid. Add 15 mL of 1 N sodium hydroxide and 300 mg of hydroxy naphthol blue, and titrate with 0.05 M edetate disodium until the solution is a distinct blue in color. Each mL of 0.05 M edetate disodium is equivalent to 2.004 mg of Ca.

Calcium Pantothenate BP Ph Eur
Ph. Eur.
C18H32CaN2O10 --- 476.5 --- CAS 137-08-6
Action and use: Component of vitamin B.

DEFINITION
Calcium pantothenate contains not less than 98.0 per cent and not more than the equivalent of 101.0 per cent of calcium bis[3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate], calculated with reference to the dried substance.

CHARACTERS
A white or almost white powder, slightly hygroscopic, freely soluble in water, slightly soluble in alcohol.

IDENTIFICATION
A. Specific optical rotation.
B. Examine the chromatograms.
C. To 1 mL of solution S (see Tests) add 1 mL of dilute sodium hydroxide solution and 0.1 mL of copper sulfate solution. A blue colour develops.
D. It gives reaction (a) of calcium.

TESTS
Solution S: Dissolve 2.50 g in carbon dioxide-free water and dilute to 50.0 mL with the same solvent.
Appearance of solution: Solution S is clear and colourless.
pH: The pH of solution S is 6.8 to 8.0.
Specific optical rotation: + 25.5 to + 27.5, determined on solution S and calculated with reference to the dried substance.
3-Aminopropionic acid: To pass the test.
Chlorides: 5 mL of solution S diluted to 15 mL with water complies with the limit test for chlorides (200 ppm).
Loss on drying: Not more than 3.0 per cent, determined on 1.000 g by drying in an oven at 105C.

ASSAY
Dissolve 0.180 g in 50 mL of anhydrous acetic acid. Titrate with 0.1 M perchloric acid determining the end-point potentiometrically.
1 mL of 0.1 M perchloric acid is equivalent to 23.83 mg of C18H32CaN2O10.

Calcium Pantothenate FCC Food Grade
D-Calcium Pantothenate; Dextro Calcium Pantothenate
HOCH2C(CH3)2CH(OH)CONH(CH2)2COO Ca2
C18H32CaN2O10 Formula weight 476.54
CAS 137-08-6

DESCRIPTION
Calcium Pantothenate occurs as a slightly hygroscopic, white powder. It is the calcium salt of the dextrorotatory isomer of pantothenic acid. It is stable in air. One gram dissolves in about 3 mL of water. It is soluble in glycerin, but is practically insoluble in alcohol, in chloroform, and in ether.
Function: Nutrient.

REQUIREMENTS
Identification:
A. A 1:20 aqueous solution gives positive tests for Calcium.
B. The infrared absorption spectrum of a potassium bromide dispersion of the sample, previously dried at 105C for 3 h, exhibits relative maxima at the same wavelengths as those of a similar preparation of USP Calcium Pantothenate.
C. Boil 50 mg of sample in 5 mL of 1 N sodium hydroxide for 1 min, cool, and add 5 mL of 1 N hydrochloric acid and 2 drops of ferric chloride. A strong yellow color appears.
Assay: Not less than 97.0% and not more than 103.0% of Dextrorotatory Calcium Pantothenate (C18H32CaN2O10) after drying.
Alkalinity: Passes test.
Alkaloids: Passes test.
Calcium Content: Not less than 8.2% and not more than 8.6% of calcium (Ca) after drying.
Lead: Not more than 2 mg/kg.
Loss on Drying: Not more than 5.0%.
Optical (Specific) Rotation 25C: Between +25.0° and +27.5° after drying.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

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Calcium pantothenate or Calcium D-pantothenate SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 07-Oct-20

Product Name & Other Names: Calcium pantothenate or Calcium D-pantothenate.
CAS No.: 137-08-6
EINECS EC Code number: 205-278-9
Molecular Weight: 476.5
Chemical Formula: C18H32CaN2O10
Relevant uses and uses advised against (if any): Laboratory Chemicals and Industrial Manufacturing Use.
Supplier: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Hazards not otherwise classified (HNOC):
May causes mild skin irritation.
May causes mild eye irritation.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

Product Name/ Synonyms: Calcium pantothenate or Calcium D-pantothenate.
CAS No.: 137-08-6
EINECS EC Code number: 205-278-9

Inhalation: Remove to fresh air. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases, and groin. Cold water may be used. Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash contaminated clothing & Shoes before reusing.
Eye Contact: Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Do not use an eye ointment. Seek medical attention.
Notes to Physician: Treat symptomatically.

Fire: Not considered to be a fire hazard.
Explosion: Not considered to be an explosion hazard.
Fire Extinguishing Media: In case of fire, use carbon dioxide, water spray, dry chemical powder or appropriate foam.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. Water mist may be used to keep containers cool.
Special Hazards arising from the substance or mixture: Fumes, Carbon oxides, Nitrogen oxides (NOx), Calcium oxide.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage:
Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to legal requirements.
Large Spill: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents.

Airborne Exposure Limits: This product does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: A white or almost white powder, slightly hygroscopic.
Odor: Odorless.
Odor threshold: Not available.
pH: 6 to 8
Relative density: Not available.
Melting Point: 195C literature.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility(ies): Not available.
Viscosity: Not available.
Molecular Weight: 476.5
Chemical Formula: C18H32CaN2O10

Stability: Stable under ordinary storage conditions. Moisture sensitive. Heat sensitive.
Hazardous Decomposition Products: At higher temperatures, substance decomposes into Calcium oxide and Nitrogen oxides, Carbon dioxide and Carbon monoxide and fumes.
Hazardous Polymerization: This substance does not polymerize.
Incompatibilities: Oxidizing agents.
Conditions to Avoid: Oxidizing agents and heat.

Oral LD50 Rat: >10 gm/kg
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as possible or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Mutagenic Effects: No information available
Reproductive Effects: No information available.
Developmental Effects: No information available.
Teratogenicity: No information available.

Environmental Toxicity: No information found.
Persistence and Degradability: No information available.
Mobility: No information available.
Results of PBT and vPvB assessment: No information available.

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused material in accordance with federal, state, and local requirements.

DOT USA & ADR/RID Europe: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods.

USA:
California Proposition 65: Not listed.
SARA 311/312 Hazards: See section 2.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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