Caffeine Anhydrous or 1,3,7-Trimethylxanthine USP BP Ph Eur FCC Food Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Caffeine Anhydrous or 1,3,7-Trimethylxanthine, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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Caffeine Anhydrous or 1,3,7-Trimethylxanthine CAS Number 58-08-2, EINECS EC Number: 200-362-1, Molecular Formula: C8H10N4O2, Molecular Weight: 194.19, HS Code 29393000

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SDS MSDS Sheet of Caffeine Anhydrous or 1,3,7-Trimethylxanthine Manufacturers

Caffeine Anhydrous
1,3,7-Trimethylxanthine USP BP Ph Eur FCC Food Grade Suppliers
Caffeine Anhydrous

Caffeine is a naturally occurring central nervous system (CNS) stimulant of the methylxanthine class and is the most widely taken psychoactive stimulant globally.

General Properties and Specifications of Caffeine Anhydrous or 1,3,7-Trimethylxanthine:
Appearance: White to almost white crystalline powder.
Solubility of 1% aq. solution: Clear colourless.
Assay: 98.5% minimum.
Loss on Drying: 0.5% maximum.
Sulfated Ash: 0.1% maximum.
Acidity: Passes test.
Heavy Metals (Pb): 0.002% maximum.
Sulfate (SO4): 0.05% maximum.
pH: around 7
Relative Density: around 1.23
Solubility: Soluble in water.
Melting Point: 234C to 239C.
Boiling Point: 416C.
Flash Point: 206C.
Storage: Room temperature.

Caffeine USP Grade Specifications:
C8H10N4O2-H2O -- 212.21
C8H10N4O2 -- 194.19
1H -Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-;
1,3,7-Trimethylxanthine CAS 58-08-2
Monohydrate CAS 5743-12-4
UNII: 3G6A5W338E
UNII: 9T65I06326

Caffeine is anhydrous or contains one molecule of water of hydration. It contains NLT 98.5% and NMT 101.0% of C8H10N4O2, calculated on the anhydrous basis.

A. Infrared Absorption
B. The retention time of the caffeine peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.
Residue on Ignition: NMT 0.1%
Organic Impurities: To pass the test.
Individual impurities: NMT 0.1%
Total impurities: NMT 0.1%
Water Determination: Dry a sample at 80° for 4 h: the anhydrous form loses NMT 0.5% of its weight, and the hydrous form loses NMT 8.5% of its weight.

Caffeine BP Ph Eur Grade Specifications:
Anhydrous Caffeine
C8H10N4O2 --- 194.2 CAS 58-08-2
Action and use: Central nervous system stimulant.

Content: 98.5 per cent to 101.5 per cent (dried substance).

Appearance: White or almost white, crystalline powder or silky, white or almost white, crystals.
Solubility: Sparingly soluble in water, freely soluble in boiling water, slightly soluble in ethanol (96 per cent). It dissolves in concentrated solutions of alkali benzoates or salicylates.
It sublimes readily.

First identification: A, B, E
Second identification: A, C, D, E, F
A. Melting point 234C to 239C.
B. Infrared absorption spectrophotometry.
C. To 2 mL of a saturated solution add 0.05 mL of iodinated potassium iodide solution. The solution remains clear. Add 0.1 mL of dilute hydrochloric acid; a brown precipitate is formed. Neutralise with dilute sodium hydroxide solution, the precipitate dissolves.
D. In a ground-glass-stoppered tube, dissolve about 10 mg in 0.25 mL of a mixture of 0.5 mL of acetylacetone and 5 mL of dilute sodium hydroxide solution. Heat in a water-bath at 80C for 7 min. Cool and add 0.5 mL of dimethylaminobenzaldehyde solution. Heat again in a water-bath at 80C for 7 min. Allow to cool and add 10 mL of water; an intense blue colour develops.
E. Loss on drying. Maximum 0.5 per cent, determined on 1.000 g by drying in an oven at 105C for 1 h.
F. It gives the reaction of xanthines.

Solution S: Dissolve 0.5 g with heating in 30 mL of carbon dioxide-free water prepared from distilled water, cool and dilute to 50 mL with the same solvent.
Appearance of solution: Solution S is clear and colourless.
Acidity: To 10 mL of solution S add 0.05 mL of bromothymol blue solution; the solution is green or yellow. No more than 0.2 mL of 0.01 M sodium hydroxide is required to change the colour of the indicator to blue.
Related substances: To pass the test by chromatography.
Sulfates: Maximum 500 ppm, determined on 15 mL of solution S.
Loss on drying: Maximum 0.5 per cent, determined on 1.000 g by drying in an oven at 105C for 1 h.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.

Caffeine Hydrate BP Ph Eur Grade is also available.
C8H10N4O2,H2O -- 212.2 CAS 5743-12-4

Caffeine FCC Food Grade Specifications:
C8H10N4O2 Formula weight, anhydrous 194.19
C8H10N4O2-H2O Formula weight, monohydrate 212.21
CAS: anhydrous 58-08-2

Caffeine occurs as a white powder or as white, glistening needles, usually matted together. It may be compacted or compressed into free-flowing granules or pellets. It is odorless and has a bitter taste. Caffeine is anhydrous or contains one molecule of water of hydration. Its solutions are neutral to litmus. The hydrate is efflorescent in air, and 1 g is soluble in about 50 mL of water, in 75 mL of alcohol, in about 6 mL of chloroform, and in 600 mL of ether.
Function: Flavoring agent.

Labeling: Indicate whether it is anhydrous or hydrous.
A. Dissolve about 5 mg of sample in 1 mL of hydrochloric acid contained in a porcelain dish, add 50 mg of potassium chlorate, and evaporate on a steam bath to dryness. Invert the dish over a vessel containing a few drops of 6 N ammonium hydroxide. The residue acquires a purple color, which disappears on the addition of a solution of a fixed alkali.
B. The infrared absorption spectrum of a mineral oil dispersion of the sample, previously dried at 80° for 4 h, exhibits relative maxima at the same wavelengths as those of a similar preparation of USP Caffeine Reference Standard.
Assay: Not less than 98.5% and not more than 101.0% of C8H10N4O2, calculated on the anhydrous basis.
Lead: Not more than 1 mg/kg.
Melting Range Anhydrous: Between 235° and 237.5°.
Other Alkaloids: Passes test.
Readily Carbonizable Substances: Passes test.
Residue on Ignition: Not more than 0.1%.
Water Anhydrous: Not more than 0.5%; Hydrous: Not more than 8.5%.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

We also manufacture and supply as under:

Caffeine Anhydrous or 1,3,7-Trimethylxanthine

N,O-Bis-(Trimethylsilyl) Trifluoro Acetamide

Cetyltrimethylammonium Bromide

Decyltrimethylammonium Bromide

Isooctane or 2,2,4-Trimethylpentane

Trimethylolpropane Trioleate

Xanthan Gum,


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Last 15 April, 2024

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Caffeine Anhydrous or 1,3,7-Trimethylxanthine SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet

1. Product Identification

Product Name & Other Names: Caffeine Anhydrous or 1,3,7-Trimethylxanthine.
CAS No.: 58-08-2
EINECS EC Number: 200-362-1
Molecular Weight: 194.19
Chemical Formula: C8H10N4O2
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.

2. Hazards Identification

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Acute toxicity, Oral (Category 4), H302

Labeling according to GHS & Regulation (EC) No 1272/2008

GHS Label Elements

Signal Words: Warning

Hazard statements:
H302: Harmful if swallowed.

Precautionary statements:
P264: Wash … thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P330: Rinse mouth.
P302+352: IF ON SKIN: Wash with soap and water.
P332+313: If skin irritation occurs: Get medical advice/attention.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.
P501: Dispose of contents/container to authorized agents only.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbols:
Xn Harmful.
Risk Phrases:
R22 Harmful if swallowed.

3. Composition/Information on Ingredients

Product Name & Other Names: Caffeine Anhydrous or 1,3,7-Trimethylxanthine.
CAS No.: 58-08-2
EINECS EC Number: 200-362-1

4. First Aid Measures

Always seek medical attention after first aid measures are provided.

Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

5. Fire Fighting Measures

Flammability of the Product: Non-flammable. However, it may burn at high temperature.
Products of Combustion: Carbon oxides, Nitrogen oxides (NOx) and fumes.
Explosion: Not an Explosive item.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Use means suitable for extinguishing surrounding fire.
Special Information: Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and a suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place. Containers may explode on heating.

6. Accidental Release Measures

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: Avoid dust/mist formation. Avoid breathing dust/mist/vapor. Ensure adequate ventilation. Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill: Contain spilled material. Avoid touching the spilled material. Do not let the product enter drains. Sweep up or vacuum up spillage and collect in suitable container for disposal. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system.

7. Handling and Storage

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents and bases. Keep away from direct sunlight and heat source. Storage: Room temperature.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

9. Physical and Chemical Properties

Appearance: White to almost white crystalline powder.
Odor: Odorless.
Odor threshold: Not available.
pH: Not available.
Relative density: around 1.23
Melting Point: 234C to 239C.
Initial boiling point and boiling range: 416C.
Flash point: 206C.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Very slightly soluble in water. Soluble in ethanol and acetone.
Viscosity: Not available.
Molecular Weight: 194.19
Chemical Formula: C8H10N4O2

10. Stability and Reactivity

Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: It emits carbon oxides, nitrogen oxides and toxic fumes when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents.
Conditions to Avoid: Incompatibles heat, light, and moisture.

11. Toxicological Information

Toxicity data
LD50 Oral - Rat - - 367.7 mg/kg.
LC50 Inhalation - Rat - 4 h – 4.94 mg/l - aerosol.
LD50 Dermal - Rat - >2000 mg/kg
Carcinogenic Effects: Not a reported carcinogen by IARC NTP ACGIH OSHA.
Mutagenic Effects: Not available.
Teratogenic Effects: Not available.
Developmental Toxicity: Not available.

12. Ecological Information

Toxicity to fish: static test LC50 - Leuciscus idus (Golden orfe) - ca. 87 mg/l - 96 h.
Toxicity to daphnia and other aquatic invertebrates: static test EC50 - Daphnia magna (Water flea) - 182 mg/l - 48 h.
Environmental Fate: Not classified as environmentally hazardous.
Persistence and Degradability: Unlikely to persist.
Bioaccumulation/ Accumulation: No information available.
Mobility: Likely to be mobile.

13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of containers and unused contents in accordance with federal, state, and local requirements.

14. Transport Information

DOT USA, TDG Canada & ADR/RID Europe: Not regulated.
IMDG/IMO & IATA/ICAO: Not regulated.

15. Regulatory Information

SARA 311/312 Hazards
: Immediate (acute) health hazard as per section 2.
California Prop.65: Not Listed.

16. Other Information
European Labeling in Accordance with EC Directives:
H302: Harmful if swallowed.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbols:
Xn Harmful.
Risk Phrases:
R22 Harmful if swallowed.

Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.