Povidone-Iodine or PVP-I or Poly(vinylpyrrolidone)–Iodine complex BP Ph Eur USP Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Povidone-Iodine or PVP-I or Poly(vinylpyrrolidone)–Iodine complex, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal etc.

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Povidone-Iodine or PVP-I or Poly(vinylpyrrolidone)–Iodine complex BP Ph Eur USP Grade Manufacturers, SDS GHS MSDS Sheet

Povidone-Iodine or PVP-I or Poly(vinylpyrrolidone)–Iodine complex: CAS Number: 25655-41-8, EINECS EC Number: 607-771-8 or (918-309-2), Molecular Formula: (C6H9NO)n-xI, Molecular Weight: Variable, HS Code ---**

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SDS MSDS Sheet of Povidone-Iodine or PVP-I or Poly(vinylpyrrolidone)–Iodine complex Manufacturers

Povidone-Iodine
PVP-I or Poly(vinylpyrrolidone)–Iodine complex Pure Suppliers
Povidone-Iodine or PVP-I

We manufacture and supply as under:

Crospovidone

Povidone-Iodine

Povidone; Polyvinylpyrrolidone.

Povidone-iodine (PVP-I), also known as iodopovidone, is an antiseptic used for skin disinfection before and after surgery. It may be used both to disinfect the skin of the patient and the hands of the healthcare providers. It may also be used for minor wounds.It may be applied to the skin as a liquid or a powder. Povidone-iodine is a broad spectrum antiseptic for topical application in the treatment and prevention of wound infection. It may be used in first aid for minor cuts, grazes, burns, abrasions and blisters.

General specifications of Povidone-Iodine are as under:
Appearance: Brown to Red powder.
Solubility: Soluble in water.
Solubility @ 100mg/ml in water: Brown.
Loss on drying: maximum 8%.
Nitrogen (Dry Basis): 9.5 - 11.5 %.
Iodine: 9.0 - 12.0 %.
Residue on ignition: Negligible.
Heavy Metals (as Lead): maximum 20 ppm.


Povidone-Iodine USP Grade
(C6H9NO)n.xI
2-Pyrrolidinone, 1-ethenyl-, homopolymer, compound with iodine.
1-Vinyl-2-pyrrolidinone polymer, compound with iodine [25655-41-8].
Povidone-Iodine is a complex of Iodine with Povidone. It contains not less than 9.0 percent and not more than 12.0 percent of available iodine (I), calculated on the dried basis.

Packaging and storage: Preserve in tight containers.
Identification:
A: Add 1 drop of a solution (1 in 10) to a mixture of 1 mL of starch TS and 9 mL of water: a deep blue color is produced.
B: Spread 1 mL of a solution (1 in 10) over an area of about 20 cm × 20 cm on a glass plate, and allow to air-dry at room temperature in an atmosphere of low humidity overnight: a brown, dry, non-smearing film is formed, and it dissolves readily in water.
Loss on drying: Dry 5.0 g of it at 105 until the difference between two successive weighings at 1-hour intervals is not greater than 5.0 mg: it loses not more than 8.0% of its weight.
Residue on ignition: not more than 0.025%, from 2 g.
Iodide ion: Determination of total iodine: Dissolve about 500 mg of Povidone-Iodine, accurately weighed, in 100 mL of water in a 250-mL conical flask. Add sodium bisulfite until the color of iodine has disappeared. Add 25.0 mL of 0.1 N silver nitrate and 10 mL of nitric acid, and mix. Titrate the excess silver nitrate with 0.1 N ammonium thiocyanate, using ferric ammonium sulfate as the indicator. Perform a blank determination. Each mL of 0.1 N silver nitrate is equivalent to 12.69 mg of I. From the percentage of total iodine, calculated on the dried basis, subtract the percentage of available iodine (see Assay for available iodine), to obtain the percentage of iodide ion. Not more than 6.6%, calculated on the dried basis, is found.
Heavy metals: 0.002%.
Nitrogen content: Not less than 9.5% and not more than 11.5% of N is found, calculated on the dried basis.
Assay for available iodine: Place about 5 g of Povidone-Iodine, accurately weighed, in a 400-mL beaker, and add 200 mL of water. Cover the beaker, and stir by mechanical means at room temperature for not more than 1 hour to dissolve as completely as possible. Titrate immediately with 0.1 N sodium thiosulfate, adding 3 mL of starch as the endpoint is approached. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N sodium thiosulfate is equivalent to 12.69 mg of I.


Povidone-Iodine Solution BP Ph Eur Grade
Povidone-Iodine Cutaneous Solution
Action and use: Disinfectant.

DEFINITION
Povidone-Iodine Solution is either an aqueous solution of Iodinated Povidone or it is prepared by the interaction between Iodine and Povidone. It is a cutaneous solution. The solution complies with the requirements stated under Liquids for Cutaneous Application and with the following requirements.
Content of available iodine, I: 0.85 to 1.20% w/v.

CHARACTERISTICS
A deep brown liquid.

IDENTIFICATION
A. Dilute 1 mL to 20 mL with water and add 1 mL of the resulting solution to a mixture of 1 mL of starch mucilage and 9 mL of water. A deep blue colour is produced.
B. Transfer 10 mL to a small flask and cover the mouth of the flask with filter paper moistened with 0.05 mL of starch mucilage. No blue colour is produced on the paper within 60 seconds.
C. Dilute 20 mL to 100 mL with water. To 10 mL add drop wise 0.1M sodium thiosulfate until the colour of the iodine is just discharged. Reserve 5 mL of the resulting solution for test D. To 5 mL of the solution add 10 mL of 1M hydrochloric acid and 5 mL of a 7.0% w/v solution of potassium dichromate. A red precipitate is produced.
D. To 5 mL of the solution reserved in test C add 2 mL of ammonium cobaltothiocyanate solution previously acidified with 5M hydrochloric acid. A blue precipitate is produced.

TESTS
Acidity: pH, 3.0 to 6.5.
Iodide: Not more than 0.6% w/v when determined by the following method. Dilute 5 mL of the solution being examined to 100 mL with water and add sodium metabisulfite until the colour of iodine has disappeared. Add 25 mL of 0.1M silver nitrate VS, 10 mL of nitric acid and 5 mL of ferric ammonium sulfate solution. Titrate with 0.1M ammonium thiocyanate. Repeat the procedure without the solution being examined. Each mL of 0.1M silver nitrate is equivalent to 12.69 mg of total iodine. Calculate the percentage content of total iodine and subtract the percentage content of available iodine determined in the Assay to obtain the percentage content of iodide.

ASSAY
To 10 mL add 10 mL of 0.1M hydrochloric acid and sufficient water to produce 150 mL and titrate with 0.02Msodium thiosulfate determining the end point potentiometrically. Each mL of 0.02M sodium thiosulfate is equivalent to 2.538 mg of I.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

We manufacture and supply iodine chemicals or derivatives a under:

Ammonium Iodate

Ammonium Iodide

4-Bromoiodobenzene

Butyl Iodide

Calcium Iodate

Calcium Iodide

4-Chloroiodobenzene

Chloroiodomethane

Clioquinol

Cuprous Iodide

Dess Martin Periodinane

4,4'-Diiodobiphenyl

1,4-Diiodobenzene

Diiodomethane

3,5-Diiodosalicylic Acid

Ethylenediamine dihydroiodide

Ethylhexyl Iodide

Ethyl Iodide

Hydroiodic Acid

Iodoquinol or Diiodohydroxyquinoline

Iodic Acid

Iodine Monochloride

4-lodo Oxindole

6 lodo Oxindole

3-Iodoaniline

4-Iodoaniline

4-Iodoanisole

Iodobenzene

Iodobenzene Diacetate

Iodoform

4-Iodophenol

4-Iodotoluene

5-Iodoanthranilic acid or 2-Amino-5-Iodobenzoic acid

2-Iodobenzoic Acid

5-Iodo-2-Methylbenzoic Acid

Iodopropynyl Butyl Carbamate

N-Iodosuccinimide

Iron Iodide or Ferrous Iodide

Methyltriphenylphosphonium Iodide

Mercury Iodide

Methyl Iodide

Methyl-2-Iodobenzoate

Periodic Acid

Potassium Iodate

Potassium Iodide

Povidone-Iodine

Propyl Iodide

Sodium Iodide

Sodium Metaperiodate

Tetrabutylammonium Iodide

Thymol Iodide

Trimethylsulfoxonium Iodide

Zinc Iodide.

Manufacturers:

MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +912223770100, +912223726950
Current Date Time in India GMT+5:30

e-mail: info@mubychem.com

USA, Canada, Mexico and other American
neighbouring buyers may
e-mail: us@mubychem.com
Call toll-free 1-844-682-9243 (1-844-MUBYCHEM)

Manufacturers india
Copyright and Usual Disclaimer is Applicable.
Last 27 August, 2022

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Povidone-Iodine or PVP-I SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet
15-Nov-20

Section 1 - Chemical Product and Identification

Product Name & Other Names: Povidone-Iodine or PVP-I or Poly(vinylpyrrolidone)–Iodine complex.
CAS Number: 25655-41-8
EINECS EC Code: 607-771-8 or (918-309-2)
Chemical Formula: (C6H9NO)n-xI
Molecular Weight: Variable
Relevant uses and uses advised against (if any): Laboratory Chemicals and Industrial Use.
Supplier: As per letterhead.

Section 2 - Hazards Identification

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Labeling according GHS & Regulation (EC) No 1272/2008

GHS Label Elements
NONE

Signal Word: None

Hazards not otherwise classified (HNOC):
May causes mild skin irritation.
May causes mild eye irritation.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352 - IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

Section 3 - Composition, Information on Ingredients

Product Name & Other Names: Povidone-Iodine or PVP-I or Poly(vinylpyrrolidone)–Iodine complex.
CAS Number: 25655-41-8
EINECS EC Code: 607-771-8 or (918-309-2)

Section 4 - First Aid Measures

Always seek medical advice after the first aid treatment.
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid. Wash mouth out with water.
Inhalation: Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.

Section 5 - Fire Fighting Measures

General Information: Water runoff can cause environmental damage. Dike and collect water used to fight fire. Wear appropriate protective clothing to prevent contact with skin and eyes. Wear a self-contained breathing apparatus (SCBA) to prevent contact with thermal decomposition products.
Extinguishing Media: For small fires, use water spray, dry chemical, carbon dioxide or chemical foam.
Special hazards arising from the substance: Hydrogen iodide, Ammonia and Nitrogen oxides, Toxic fumes.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Section 6 - Accidental Release Measures

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.

Section 7 - Handling and Storage

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents, moist air or water, strong acids.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls: Good general ventilation should be sufficient to control airborne levels. Facilities storing or utilizing the material should be equipped with an eyewash facility and a safety shower.
Exposure Limits: Not listed.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Section 9 - Physical and Chemical Properties

Appearance: Brown liquid.
Odor: Typical.
Odor threshold: Not available.
pH: 3 to 6.5
Relative density: Between 1 and 1.1
Melting point/freezing point: Not available.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Soluble in water.
Viscosity: Not available.
Chemical Formula: (C6H9NO)n-xI
Molecular Weight: Variable.

Section 10 - Stability and Reactivity

Chemical Stability: Stable.
Conditions to Avoid: High temperatures, light, exposure to moist air or water, strong acids, strong oxidizing agents.
Hazardous Decomposition Products: Toxic fumes of iodine or hydrogen iodide and ammonia and nitrogen oxide.
Hazardous Polymerization: Has not been reported.

Section 11 - Toxicological Information

LD50 Oral - Rat - Not available
LD50 Dermal - Rat - > 2.500 mg/kg
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as possible or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Teratogenic Effects: Not available.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.

Section 12 - Ecological Information

Toxicity to fish: static test LC50 - Leuciscus idus (Golden orfe) - 4,6 - 10 mg/l - 96 h.
Toxicity to daphnia and other aquatic invertebrates: static test EC50 - Daphnia magna (Water flea) - 2,79 mg/l - 48 h
Mobility in soil: No information reported.
Persistence and degradability: No information reported.
Results of PBT and vPvB assessment: No information reported.
Other adverse effects: Discharge into the environment must be avoided.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.

Section 14 - Transport Information

DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods
IMDG/IMO: Not dangerous goods
IATA: Not dangerous goods.

Section 15 - Regulatory Information

USA Regulations:
SARA 311/312 Hazards: No SARA Hazards
California Prop. 65 Components: Not listed.

Section 16 - Additional Information

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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