Venlafaxine HCl or Venlafaxine Hydrochloride USP IP BP Ph Eur JP Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Venlafaxine HCl or Venlafaxine Hydrochloride USP IP BP Ph Eur JP Grade, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy Portugal, Bangladesh, etc.

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Venlafaxine HCl or Venlafaxine Hydrochloride CAS Number 99300-78-4, EINECS EC Number: 200-659-6, Molecular Formula: C17H28ClNO2 or C17H27NO2-HCl, Molecular Weight: 313.86, HS Code 29225090 or 38220090

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Venlafaxine HCl or Venlafaxine Hydrochloride.

Venlafaxine Hydrochloride USP Grade Speicifications:
C17H27NO2-HCl --- 313.86
Cyclohexanol, 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-, hydrochloride;
(±)-1-[α-[(Dimethylamino)methyl]-p-methoxybenzyl]cyclohexanol hydrochloride
CAS 99300-78-4
UNII: 7D7RX5A8MO
UNII: GRZ5RCB1QG

DEFINITION
Venlafaxine Hydrochloride contains NLT 98.0% and NMT 102.0% of venlafaxine hydrochloride (C17H27NO2-HCl), calculated on the dried basis.

IDENTIFICATION
A. Infrared Absorption
B. The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.
C. Identification Tests—General, Chloride: Meets the requirements
Residue on Ignition: NMT 0.1%
Organic Impurities: To pass the test by chromatography.
Loss on Drying: Dry under vacuum at 105C for 3 h. Acceptance criteria: NMT 0.5%
Packaging and Storage: Preserve in well-closed containers, and store at controlled room temperature.

Venlafaxine Hydrochloride BP Ph Eur Grade:
C17H28ClNO2 --- 313.9 CAS 99300-78-4
Action and use: Inhibition of 5HT and noradrenaline reuptake; antidepressant.

DEFINITION
1-[(1RS)-2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride.
Content: 99.0 per cent to 101.0 per cent (dried substance).

CHARACTERS
Appearance: White or almost white powder.
Solubility: Freely soluble in water and in methanol, soluble in anhydrous ethanol, slightly soluble or practically insoluble in acetone. It shows polymorphism.

IDENTIFICATION
A. Infrared absorption spectrophotometry.
B. It gives reaction of chlorides.

TESTS
Acidity or alkalinity: Dissolve 0.20 g in carbon dioxide-free water and dilute to 10 mL with the same solvent. Add 0.05 mL of methyl red solution and 0.1 mL of 0.01 M hydrochloric acid. The solution is pink. Not more than 0.2 mL of 0.01 M sodium hydroxide is required to change the colour of the indicator to yellow.
Related substances: To pass the test by Liquid chromatography.
Loss on drying: Maximum 0.5 per cent, determined on 1.000 g by drying in vacuo at 80C for 3 h.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.

For Original Monographs of IP Indian Pharmacopoeia EP Ph Eur European Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

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Venlafaxine Hydrochloride or Venlafaxine HCL SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 20-Sept-24

Product Name & Other Names: Venlafaxine Hydrochloride or Venlafaxine HCL.
CAS No.: 99300-78-4
EINECS, EC Number: 200-659-6
Molecular Weight: 313.86
Chemical Formula: C17H28ClNO2
Relevant uses and uses advised against (if any): Laboratory chemicals, Manufacture of substances
Supplier: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Specific target organ toxicity - repeated exposure (Category 1), H372
Chronic aquatic toxicity (Category 2), H411

Hazard statements:
H372 Causes damage to organs through prolonged or repeated exposure.
H410: Toxic to aquatic life with long lasting effects.

Precautionary statements:
P202: Do not handle until all safety precautions have been read and understood.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P264 Wash thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308+313: IF exposed or concerned: Get medical advice/attention.
P337+313: If eye irritation persists get medical advice/attention.
P342+311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P391: Collect spillage.
P405: Store locked up.
P501: Dispose of contents/container in accordance with local/regional/national/international regulation.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
N Dangerous for Environment.
Risk Phrase:
R48 Danger of serious damage to health by prolonged exposure.
R 51/53 Toxic to aquatic organisms, may cause long term adverse effects in the aquatic environment.

Product Name & Other Names: Venlafaxine Hydrochloride or Venlafaxine HCL.
CAS No.: 99300-78-4
EINECS, EC Number: 200-659-6

Eyes: Immediately flush eyes with excess water for 15 minutes, lifting lower and upper eyelids occasionally.
Skin: Immediately flush skin with excess water for 15 minutes while removing contaminated clothing.
Ingestion: Call Emergency Medical immediately. Rinse mouth with cold water. Give the victim 1-2 cups of water or milk to drink. Induce vomiting immediately.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration.
Notes to Physician: Treat symptomatically.

It is a non-flammable solid. However, it can burn at high temperature.
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Avoid solid water jet as it can scatter the fire.
Protective equipment and precautions for firefighters: Use water spray, foam, or dry chemical to extinguish fire. Firefighters should wear full firefighting turn-out gear and respiratory protection. Cool container with water spray.
Special hazards arising from the substance: Hydrogen chloride, carbon oxides, nitrogen oxide and fumes.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Storage: Room Temperature. Recommended in a cool and dark place, <15C. Ok to freeze. Light Sensitive.

Exposure guidelines: This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Physical state and appearance: White to almost white powder or crystal.
Odor: Not available.
Odor threshold: Not available.
pH (1% soln/water): Not available.
Relative density: Not available.
Melting Point: 217C literature.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Soluble in methanol.
Viscosity: Not available.
Molecular Weight: 313.86
Chemical Formula: C17H28ClNO2

Avoid heat and ignition sources.
Stability: Stable under normal conditions of use and storage.
Incompatibility: Heat and strong oxidizing agents. Heat.
Hazardous Decomposition Products: Hydrogen chloride, carbon oxides, nitrogen oxide and fumes.
Hazardous Polymerization: Has not been reported.

LD50 Oral Rat No information found.
Acute inhalation toxicity: LC50, 4 h, Rat, 4.47 mg/l
Carcinogenicity: No information found.
Reproductive toxicity: No information found.
Developmental Effects: No information found.
Teratogenicity: No information found.

Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna (Water flea) - 38 mg/l - 48 h.
Ecotoxicity (aquatic and terrestrial): Toxic to aquatic life with long lasting effects.
Persistence and Degradability: Not available.
Mobility: Not available.
Results of PBT and vPvB assessment: Not available.

DOT USA and ADR/RID Europe:
UN-No: UN3077
Proper Shipping Name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
Proper technical name: ((Venlafaxine hydrochloride)
Hazard Class: 9; Packing Group: III.
TDG:
UN-No: UN3077
Proper Shipping Name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
Proper technical name: ((Venlafaxine hydrochloride)
Hazard Class: 9; Packing Group: III.
IATA
UN-No: UN3077
Proper Shipping Name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
Proper technical name: ((Venlafaxine hydrochloride)
Hazard Class: 9; Packing Group: III.
IMDG/IMO
UN-No: UN3077
Proper Shipping Name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
Proper technical name: ((Venlafaxine hydrochloride)
Hazard Class: 9; Packing Group: III.

USA:
SARA 313 Components: Not Listed
SARA 311/312 Hazard Categories: Acute Health Hazard, Chronic Health Hazard
California Proposition 65: Not listed.

European Labeling in Accordance with EC Directives:
H372 Causes damage to organs through prolonged or repeated exposure.
H411: Toxic to aquatic life with long lasting effects.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
N Dangerous for Environment.
Risk Phrase:
R20 Harmful by inhalation.
R48 Danger of serious damage to health by prolonged exposure.
R 51/53 Toxic to aquatic organisms, may cause long term adverse effects in the aquatic environment.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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