Valproic Acid or 2-Propylpentanoic Acid USP BP Ph Eur Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Valproic Acid or 2-Propylpentanoic Acid USP BP Ph Eur Grade, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy Portugal, Bangladesh, etc.

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Valproic Acid or 2-Propylpentanoic Acid CAS Number 99-66-1, EINECS EC Number: 202-777-3, Molecular Formula: C8H16O2, Molecular Weight: 144.21, HS Code 29159090

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Valproic Acid or 2-Propylpentanoic Acid.

Valproic acid or VPA or Dipropylacetic acid or 2-Propylvaleric acid or 2-Propylpentanoic acid is a as a highly prevalent medication with multifaceted therapeutic applications in various neurological and psychiatric disorders. The therapeutic uses of VPA include epilepsy treatment across different seizure types, bipolar disorder management, and migraine prophylaxis. Divalproex sodium, valproate sodium, and valproic acid, are all similar medications that are used by the body as valproic acid.

General Properties and Specifications of Valproic acid or VPA or Dipropylacetic acid or 2-Propylvaleric acid or 2-Propylpentanoic acid:
Appearance: Colorless liquid.
Assay: >99%
Odor: Characteristic odor.
Relative Density: about 0.92
Boiling Point: 222C literature.
Flash Point: 111C.
Solubility: Very slightly soluble in water. Freely soluble in methanol, alcohol, acetone.
Storage: Room temperature. Preferably refrigerated.

Valproic Acid USP Grade Specifications:
C8H16O2 --- 144.21
Pentanoic acid, 2-propyl-;
Propylvaleric acid
CAS 99-66-1
UNII: 614OI1Z5WI

DEFINITION
Valproic Acid contains NLT 98.0% and NMT 102.0% of valproic acid (C8H16O2), calculated on the anhydrous basis.

IDENTIFICATION
A. Infrared Absorption
B. The retention time of the major peak of the Sample solution corresponds to that of the Standard solution.
Residue on Ignition: NMT 0.1%
Organic Impurities: To pass the test by chromatography.
Water Determination: NMT 1.0%
Packaging and Storage: Preserve in tight glass, stainless steel, or polyethylene (HDPE) containers.

Valproic Acid BP Ph Eur Grade Specifications:
C8H16O2 --- 144.2 CAS 99-66-1
Action and use: Antiepileptic.

DEFINITION
2-Propylpentanoic acid.
Content: 99.0 per cent to 101.0 per cent.

CHARACTERS
Appearance: Colourless or very slightly yellow, clear liquid, slightly viscous.
Solubility: Very slightly soluble in water, miscible with ethanol (96 per cent) and with methylene chloride. It dissolves in dilute solutions of alkali hydroxides.

TESTS
Appearance of solution: The solution is clear and not more intensely coloured than reference solution.
Dissolve 2.0 g in dilute sodium hydroxide solution and dilute to 10 mL with the same alkaline solution.
Related substances: To pass the test by Gas chromatography.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
Storage: In an airtight container.

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Valproic Acid or 2-Propylpentanoic Acid SDS GHS Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 03-Oct-24

Product Name & Other Names: Valproic Acid or 2-Propylpentanoic Acid.
CAS Number: 99-66-1
EINECS EC Number: 202-777-3
Molecular Formula: C8H16O2
Molecular Weight: 144.21
Relevant uses and uses advised against (if any): Fracturing and Industrial Manufacturing Use.
Supplier: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Acute toxicity, Oral (Category 4), H302
Skin irritation Category 2, H315
Serious eye damage (Category 1), H318
Reproductive toxicity Category 1B - H360

Hazard Statements:
H302 Harmful if swallowed.
H315 Causes skin irritation.
H318 Causes serious eye damage.
H360: May damage fertility and the unborn child.

Precautionary Statements:
P201: Obtain special instructions before use.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P264: Wash contaminated parts thoroughly after handling.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P281: Use personal protective equipment as required.
P362: Take off contaminated clothing and wash before reuse.
P301+330+331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 P352: IF ON SKIN: Wash with plenty of soap and water.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes.
P308+P310: IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
P405: Store locked up.
P501: Dispose of contents/container in accordance with local/national regulation.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
C = Corrosive.
Xn = Harmful.
Risk Phrases:
R22 Harmful if swallowed.
R38 Irritating to skin.
R41 Risk of serious damage to eyes.
R60 May impair fertility.
R61 May cause harm to the unborn child.

Product Name & Other Names: Valproic Acid or 2-Propylpentanoic Acid.
CAS Number: 99-66-1
EINECS EC Number: 202-777-3

Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention. Wash clothing and shoes before reuse.
Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention if irritation occurs.

Flash Point: Closed cup: 111C.
Fire: Combustible. Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating. Development of hazardous combustion gases or vapors possible in the event of fire. In a fire or if heated, a pressure increase will occur and the container may burst.
Suitable extinguishing media: Water spray, dry powder, foam, carbon dioxide. Avoid solid water stream. Use means suitable for extinguishing surrounding fire.
Products of Combustion: Oxides of carbon and toxic fumes will be formed.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the positive pressure mode.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: For small spills use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to legal requirements.
Large Spill: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to legal requirements.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Product should be worked up in closed equipment as far as possible. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing. Storage: Room temperature. Preferably refrigerated.

Airborne Exposure Limits: Contains no substances with occupational exposure limit values. Ensure minimum contact.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): If the exposure limit is exceeded and engineering controls are not feasible, a full face piece particulate respirator (NIOSH type N100 filters) may be worn for up to 50 times the exposure limit or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest. If oil particles (e.g., lubricants, cutting fluids. glycerin, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-face piece positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.

Appearance: Colorless liquid.
Odor: Characteristic odor.
Odor threshold: Not available.
pH: Not available.
Relative density: about 0.92
Melting point/freezing point: Not available.
Initial boiling point and boiling range: 222C literature.
Flash Point: 111C.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Very slightly soluble in water. Freely soluble in methanol, alcohol, acetone.
Viscosity: Not available.
Molecular Formula: C8H16O2
Molecular Weight: 144.21

Stability: It is stable under ordinary conditions of use and storage. Forms explosive mixtures with air on intense heating. Dust explosion for fine distribution, when whirled up in air.
Hazardous Decomposition Products: Toxic gases and vapors may be released if involved in a fire. Oxides of carbon and nitrogen along with toxic fumes will be formed.
Hazardous Polymerization: Will not occur.
Incompatibilities: Oxidizing agents.
Conditions to Avoid: Incompatibles, heat, sunlight.

LD50 oral mouse: 1998 mg/kg
Carcinogenic Effects: Not a reported carcinogen.
Reproductive Toxicity: May damage the unborn child.
Developmental Toxicity: Not available.

Toxicity to fish: semi-static test LC50 - Danio rerio (zebra fish) - 66 mg/l - 96 h.
Toxicity to daphnia and other aquatic invertebrates: static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h.
Persistence and Degradability: Degradable.
Mobility: No information available.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused material in accordance with law.

USA:
SARA 311/312: Acute, Chronic. See section 2.
California Proposition 65: Not listed.

H302 Harmful if swallowed.
H315 Causes skin irritation.
H318 Causes serious eye damage.
H360: May damage fertility and the unborn child.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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