Tris Buffer or Tris(hydroxymethyl)aminomethane or Tris (Hydroxymethyl) Aminomethane or 2-Amino-2-(hydroxymethyl)-1,3-propanediol or THAM or Trometamol or Tromethamine BP Ph Eur USP Grade Manufacturers, with SDS GHS MSDS Sheet

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Tris Buffer or Tris(hydroxymethyl)aminomethane or Tris (Hydroxymethyl) Aminomethane or 2-Amino-2-(hydroxymethyl)-1,3-propanediol or THAM or Trometamol or Tromethamine CAS Number 77-86-1, EINECS EC Number: 201-064-4, Molecular Formula: C4H11NO3 or NH2C(CH2OH)3, Molecular Weight: 121.14, HS Code 29211190

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Tris Buffer or Tris(hydroxymethyl)aminomethane or Tris (Hydroxymethyl) Aminomethane or 2-Amino-2-(hydroxymethyl)-1,3-propanediol or THAM or Trometamol or Tromethamine.

Tris Buffer or Tris(hydroxymethyl)aminomethane or Tris or Tris (Hydroxymethyl) Aminomethane or 2-Amino-2-(hydroxymethyl)-1,3-propanediol or THAM or Trometamol or Tromethamine is extensively used in biochemistry and molecular biology as a component of buffer solutions.

General Properties and Specifications of Tris Buffer or Tris(hydroxymethyl)aminomethane or Tris (Hydroxymethyl) Aminomethane or 2-Amino-2-(hydroxymethyl)-1,3-propanediol or THAM or Trometamol or Tromethamine:
Appearance: White crystalline powder or lumps.
Assay: 99% to 100.5%
Insoluble matter: 0.005% maximum.
Water: 0.5% maximum.
Melting point: 168C to 172C literature.
Iron: 5 ppm maximum.
Heavy metals as Pb: 5 ppm maximum.
Solubility: Soluble in water.

Tromethamine USP Grade Specifications:
C4H11NO3 --- 121.14
1,3-Propanediol, 2-amino-2-(hydroxymethyl)-;
2-Amino-2-(hydroxymethyl)-1,3-propanediol CAS 77-86-1
UNII: 023C2WHX2V

DEFINITION
Tromethamine contains NLT 99.0% and NMT 101.0% of tromethamine (C4H11NO3), calculated on the dried basis.
IDENTIFICATION
A. Infrared Absorption
B.
Sample solution: 1 in 5
Analysis: To 4.5 mL of a saturated solution of salicylaldehyde add 0.5 mL of glacial acetic acid, and mix. Add 4.0 mL of the Sample solution, and mix.
Acceptance criteria: A yellow color is produced.
C.
Sample solution: 1 in 5
Analysis: To 0.5 mL of a solution (4 in 10) of ceric ammonium nitrate in 2 N nitric acid add 3 mL of water and 0.5 mL of the Sample solution, and mix.
Acceptance criteria: The color changes from light yellow to orange.

Residue on Ignition: NMT 0.1%
Melting Range or Temperature: 168C –172C
pH:
Sample solution: 1 in 20
Acceptance criteria: 10.0–11.5
Loss on Drying:
Analysis: Dry at 105C for 3 h.
Acceptance criteria: NMT 1.0%

Trometamol BP Ph Eur Grade Specifications:
C4H11NO3 --- 121.1 --- CAS 77-86-1
Action and use: Organic amine proton acceptor; alkalinizing agent.

DEFINITION
Trometamol contains not less than 99.0 per cent and not more than the equivalent of 100.5 per cent of aminomethylidynetri(methanol), calculated with reference to the dried substance.

CHARACTERS
A white or almost white, crystalline powder, or colourless crystals, freely soluble in water, sparingly soluble in alcohol, very slightly soluble in ethyl acetate.

IDENTIFICATION
First identification: B, C
Second identification: A, B, D
A. Solution S is strongly alkaline.
B. Melting point: 168C to 174C.
C. Infrared absorption spectrophotometry.
D. Examine the chromatograms obtained in the test for related substances. The principal spot in the chromatogram obtained with test solution (b) is similar in position, colour and size to the principal spot in the chromatogram obtained with reference solution (a).

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Tris Buffer or Tris(hydroxymethyl)aminomethane or Tris (Hydroxymethyl) Aminomethane or 2-Amino-2-(hydroxymethyl)-1,3-propanediol or THAM or Trometamol or Tromethamine SDS Sheet, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 15-July-23

Product Name & Other Names: Tris Buffer or Tris(hydroxymethyl)aminomethane or Tris (Hydroxymethyl) Aminomethane or 2-Amino-2-(hydroxymethyl)-1,3-propanediol or THAM or Trometamol or Tromethamine.
CAS No.: 77-86-1
EINECS EC Code: 201-064-4
Molecular Weight: 121.14
Chemical Formula: C4H11NO3 or NH2C(CH2OH)3
Relevant uses and uses advised against (if any): Industrial Manufacturing.
SUPPLIER: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Hazards not otherwise classified (HNOC):
May cause mild skin irritation.
May cause mild eye irritation.
May cause mild respiratory irritation.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Contact medical center quickly. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: Check for and remove any contact lenses. Immediately flush your eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Get medical attention.

Combustible. High heat or direct flame is necessary to cause ignition. Toxic fumes and carbon monoxide and nitrogen oxides may be formed in fire.
Explosion: Above the flash point, explosive vapor-air mixtures may be formed.
Fire Extinguishing Media: Water spray, Dry chemical, foam, or carbon dioxide. Do not use a solid stream of water, as the stream will scatter and spread the fire. Water spray may be used to keep fire exposed containers cool. Suppress (knock down) gases/vapors/mists with a water spray jet.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and a suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: Mop and pick up the material and place in an appropriate waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill: Avoid dust formation. Keep away from heat. Keep away from sources of ignition. Provide ventilation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Keep away from heat and source of fire. Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not breathe dust. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store along with incompatible materials like oxidizing agents and bases. Store in light-resistant containers. Prevent any electrostatic discharge.

Airborne Exposure Limits: Contains no substances with occupational exposure limit values.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to the substance is apparent and engineering controls are not feasible, consult an industrial hygienist. For emergencies, or instances where the exposure levels are not known, use a full-face piece positive-pressure, air-supplied respirator. WARNING: Air purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: White crystalline powder or lumps.
Odor: Not available.
Odor threshold: Not available.
pH: 10-11.5 in 1% aqueous solution.
Relative density: 1.2
Melting Point: 168C to 172C literature.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Soluble in water.
Viscosity: Not available.
Molecular Weight: 121.14
Chemical Formula: C4H11NO3 or NH2C(CH2OH)3

Stability: Stable under ordinary conditions of use and storage. Hygroscopic: absorbs moisture or water from the air.
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, nitrogen oxides and toxic fumes may form when heated to decomposition.
Hazardous Polymerization: Not reported. However, it can explode under certain conditions.
Incompatibilities: Bases, oxidizing agents, heat, and sparks.
Conditions to Avoid: Heat, flames, ignition sources and incompatibles.

Oral - Rat LD50 >5000 mg/kg.
Dermal - Rat LD50 >5000 mg/kg.
Mutagenic Effects: NA.
Reproductive Effects: No information available.
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible, or confirmed carcinogen by IARC, ACGIH, NTP or OSHA.

Toxicity to daphnia and other aquatic invertebrates: static test EC50 - Daphnia magna (Water flea) - > 980 mg/l - 48 h.
Biodegradability: Readily biodegradable
Mobility in soil: Likely to be mobile due to water solubility.
Persistence and degradability: Unlikely to persist due to water solubility.

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. Dispose of containers and unused contents in accordance with federal, state, and local requirements.

DOT USA, TDG Canada & ADR/RID Europe: Not regulated.
IMDG/IMO & IATA/ICAO: Not regulated.

USA:
SARA 311/312: See section 2.
USA California Proposition 65: No ingredient regulated by CA Prop 65 present.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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