Riboflavin Sodium Phosphate or Riboflavin 5'-phosphate Sodium or Riboflavin 5′-Monophosphate Sodium Salt BP Ph Eur EP USP FCC Food Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Riboflavin Sodium Phosphate or Riboflavin 5'-phosphate Sodium or Riboflavin 5′-Monophosphate Sodium BP Ph Eur EP USP FCC Food Grade, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy Portugal, Bangladesh, etc.

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Riboflavin Sodium Phosphate or Riboflavin 5'-phosphate Sodium or Riboflavin 5′-Monophosphate Sodium CAS Number 130-40-5 or 6184-17-4, EINECS EC Number: 204-988-6 or 244-868-0, Molecular Formula: C17H20N4NaO9P-2H2O or C17H20N4NaO9P, Molecular Weight: 514.4 or 478.33, HS Code 29362990 or 29362310

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Riboflavin Sodium Phosphate or Riboflavin 5'-phosphate Sodium or Riboflavin 5′-Monophosphate Sodium.

Riboflavin Sodium Phosphate or Riboflavin 5'-phosphate Sodium or Riboflavin 5′-Monophosphate Sodium Salt is used as a micronutrient that is the principal growth-promoting factor in naturally occurring vitamin B complexes.

General Properties and Specifications of Riboflavin Sodium Phosphate or Riboflavin 5'-phosphate Sodium or Riboflavin 5′-Monophosphate Sodium Salt:
Appearance: Yellow or orange-yellow, crystalline, hygroscopic powder.
Assay: 73.0 per cent to 79.0 per cent of riboflavin (C17H20N4O6; Mr 376.4) (dried substance).
Melting Point: 240C to 245C literature.
Solubility: Soluble in water.
Storage: Refrigerate. 2C to 8C. Hygroscopic.

Riboflavin 5′-Phosphate Sodium USP Grade Specifications:
C17H20N4NaO9P-2H2O --- 514.36
C17H20N4NaO9P --- 478.33
Riboflavin 5′-(dihydrogen phosphate), monosodium salt, dihydrate;
Riboflavine 5′-(sodium hydrogen phosphate), dihydrate
Anhydrous CAS 130-40-5
UNII: 957E53WV42

DEFINITION
Riboflavin 5′-Phosphate Sodium contains NLT the equivalent of 73.0% and NMT the equivalent of 79.0% of riboflavin (C17H20N4O6), calculated on the dried basis.

IDENTIFICATION
A. Color and Fluorescence of Solution:
Sample solution: 0.01 mg/mL in water
Analysis: Alternately expose to transmitted light and long-wavelength UV light.
Acceptance criteria: The solution is pale greenish yellow by transmitted light, and it exhibits an intense yellowish green fluorescence by reflected light under long-wavelength UV light that disappears upon the addition of mineral acids or alkalies.
B. Identification Tests: General, Sodium and Phosphate.
Free Phosphate: To pass the test by Ultraviolet-Visible Spectroscopy. --- NMT 1% as PO4.
Free Riboflavin and Riboflavin Diphosphates: To pass the test by chromatography.
Limit of Lumiflavin: To pass the test by Ultraviolet-Visible Spectroscopy.
Residue on Ignition: NMT 25.0%
Optical Rotation, Specific Rotation:
Sample solution: 15 mg/mL in 5 N hydrochloric acid. Use the solution within 15 min.
Acceptance criteria: +37.0° to +42.0°
pH: 10 mg/mL solution. Acceptance criteria: 5.0–6.5
Loss on Drying Dry a sample under vacuum over phosphorus pentoxide at 100C for 5 h: it loses NMT 7.5% of its weight.
Packaging and Storage: Preserve in tight, light-resistant containers.

Riboflavin Sodium Phosphate BP Ph Eur Grade Specifications:
C17H20N4NaO9P --- 478.3 CAS 130-40-5
Action and use: Vitamin B2.

DEFINITION
Mixture containing riboflavin 5′-(sodium hydrogen phosphate) as the main component and other riboflavin sodium monophosphates.
Content: 73.0 per cent to 79.0 per cent of riboflavin (C17H20N4O6; Mr 376.4) (dried substance). It contains a variable quantity of water.

CHARACTERS
Appearance: Yellow or orange-yellow, crystalline, hygroscopic powder.
Solubility: Soluble in water, very slightly soluble in ethanol (96 per cent).

IDENTIFICATION
A. Ultraviolet and visible absorption spectrophotometry.
B. Examine the chromatograms.
C. Dissolve about 10 mg in dilute sodium hydroxide solution and dilute to 100 mL with the same solution. Expose 1 mL of this solution to ultraviolet light at 254 nm for 5 min, add sufficient acetic acid to make the solution acidic to blue litmus paper and shake with 2 mL of methylene chloride. The lower layer shows yellow fluorescence.

TESTS
pH: 5.0 to 6.5
Specific optical rotation: + 38.0 to + 43.0 (dried substance).
Dissolve 0.300 g in 18.2 mL of hydrochloric acid and dilute to 25.0 mL with water.
Impurity E: To about 35 mg add 10 mL of methylene chloride, shake for 5 min and filter. The filtrate is not more intensely coloured than reference solution.
Related substances: To pass the test by Liquid chromatography.
Inorganic phosphate: Maximum 1.5 per cent.
Storage: In an airtight container, protected from light.

Riboflavin 5′-Phosphate Sodium FCC Food Grade:
Flavin Mononucleotide, Sodium Salt; Riboflavin 5′-Phosphate Ester Monosodium Salt; Riboflavin 5′-Phosphate Ester Monosodium Salt, Dihydrate.
C17H20N4NaO9P-2H2O Formula weight 514.36
INS: 101(ii) CAS: 130-40-5

DESCRIPTION
Riboflavin 5′-Phosphate Sodium occurs as a fine, orange-yellow, crystalline powder. One-gram dissolves in about 30 mL of water. When dry, it is not affected by diffused light, but when in solution, light induces deterioration rapidly. It is hygroscopic.
Function: Nutrient.

REQUIREMENTS
Identification: A 1.5:100 (w/v) aqueous solution responds to the Identification Test in the monograph for Riboflavin.
Assay: Not less than the equivalent of 73.0% and not more than the equivalent of 79.0% of riboflavin (C17H20N4O6), calculated on the dried basis.
Free Phosphate: Not more than 1.0%, calculated as PO4.
Free Riboflavin: Not more than 6.0%, calculated on the dried basis.
Lead: Not more than 2 mg/kg.
Loss on Drying: Not more than 7.5%.
Optical (Specific) Rotation [α]D25°: Between +37.0° and +42.0°, calculated on the dried basis.
pH of a 1:100 Solution: Between 5.0 and 6.5
Residue on Ignition: Not more than 25.0%.
Riboflavin Diphosphate: Not more than 6.0% as riboflavin (C17H20N4O6), calculated on the dried basis.

Riboflavin Sodium Phosphate or Riboflavin 5'-phosphate Sodium or Riboflavin 5′-Monophosphate Sodium Salt is found in BP Ph Eur EP JP IP USP FCC Food Grade monographs.

For Original Monographs of IP Indian Pharmacopoeia EP Ph Eur European Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

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Riboflavin Sodium Phosphate or Riboflavin 5'-phosphate Sodium or Riboflavin 5′-Monophosphate Sodium Salt SDS GHS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 04-Sept-24

Product Name & Other Names: Riboflavin Sodium Phosphate or Riboflavin 5'-phosphate Sodium or Riboflavin 5′-Monophosphate Sodium Salt.
CAS Number: 130-40-5 or 6184-17-4
EINECS EC Code: 204-988-6 or 244-868-0
Molecular Formula: C17H20N4NaO9P-2H2O or C17H20N4NaO9P
Molecular Weight: 514.4
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Hazard Class and Category Code(s), Regulation (EC) No 1272/2008 (CLP)

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Hazards not otherwise classified (HNOC):
May causes mild skin irritation.
May causes mild eye irritation.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

Skin: Rinse with water. Soap may be used. Seek Medical Aid.
Eyes: Wash eyes with plenty of water for at least 15 minutes, lifting lids occasionally. Seek Medical Aid.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Ingestion: If swallowed, induce vomiting immediately after giving two glasses of water. Never give anything by mouth to an unconscious person.

Fire: Not a fire hazard. However, it can burn at high temperature.
Flammability of the Product: Non-flammable. However, it will burn at high temperature.
Products of Combustion: Fumes and Oxides of Carbon, Phosphorous and Nitrogen.
Fire Fighting Media and Instructions: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary. Avoid solid water jet as it can scatter the fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and a suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to legal requirements.
Large Spill: Contain spilled material. Do not inhale vapors, mist, or gas. Avoid dust formation. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of it according to legal requirements.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing agents. Storage: Refrigerate. 2C to 8C. Hygroscopic. Preserve in tight, light-resistant containers.

Occupational Exposure Limits: No exposure limits known for ingredient.
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume, or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Physical state and appearance: Yellow or orange-yellow, crystalline, hygroscopic powder.
Odor: Not available.
Odor threshold: Not available.
pH: 10 mg/mL solution 5.0–6.5
Relative density: Not available.
Melting point/freezing point: 240C to 245C literature.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Soluble in water.
Viscosity: Not available.
Molecular Formula: C17H20N4NaO9P-2H2O or C17H20N4NaO9P
Molecular Weight: 514.4

Stability: It is stable at recommended storage temperature closed containers under normal storage & handling.
Hazardous decomposition products: Fumes and Oxides of Carbon, Phosphorous, Sodium, and Nitrogen compounds.
Conditions of instability: Incompatible materials, heat flame
Incompatibility with various substances: Avoid high temperatures, sparks, open flames, and moisture. Avoid contact with strong oxidizing agents.
Polymerization: Will not occur.

LD50 Oral – Rat: Not available.
Carcinogenic Effects: Not a reported carcinogen by IARC, NTP, ACGIH, OSHA.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.

Toxicity to fish: Not available.
Products of Biodegradation: Not available.
Ecotoxicity: Not regarded as dangerous for the environment. However, large, or frequent spills may have hazardous effects on the environment.
Persistence and Degradability: Not likely to persist due to water solubility.
Mobility: Likely to be mobile due to water solubility.
Bioaccumulation/ Accumulation: Degradable.
Results of PBT and vPvB assessment: No data available for assessment.

Waste Disposal: Waste must be disposed of in accordance with federal, state, and local environmental control regulations.

DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods
IMDG/IMO: Not dangerous goods
IATA: Not dangerous goods.

USA Regulations:
SARA 311/312 Hazard Categories: Not applicable. See section 2.
California Prop 65: None of the chemicals in this product are listed.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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