L-Proline or (S)-Pyrrolidine-2-carboxylic Acid USP BP Ph Eur Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of L-Proline or (S)-Pyrrolidine-2-carboxylic Acid, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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L-Proline or (S)-Pyrrolidine-2-carboxylic Acid CAS Number 147-85-3 or 4305-67-3, EINECS EC Number: 205-702-2, Molecular Formula: C5H9NO2, Molecular Weight: 115.13, FEMA: 3319, HS Code 29224990

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for L-Proline or (S)-Pyrrolidine-2-carboxylic Acid.

L-Proline or (S)-Pyrrolidine-2-carboxylic acid is an organic acid classed as a proteinogenic amino acid used in the biosynthesis of proteins. Proline and its derivatives are often used as asymmetric catalysts in proline organocatalysis reactions.

General Properties and Specifications of L-Proline or (S)-Pyrrolidine-2-carboxylic acid:
Appearance: White odorless crystals or powder.
Odor: Odorless.
Solubility: Freely soluble in water and in absolute alcohol.
Assay (On dry basis): 98.5 - 101.5%
pH: 5-7 @ 20°C for 100 g/L in water.
Residue on ignition: 0.4% maximum.
Chloride (CI): 0.05% maximum.
Sulfate (SO4): 0.03% maximum.
Iron (Fe): 30 ppm maximum.
Related impurities: To pass the test. Individual impurities : 0.5% maximum. Total impurities : 2.0% maximum.
Specific rotation [α]: -84.3° to -86.3° (40mg/ml in water).
Loss on drying: 0.4% maximum.
Relative density: 1.35-1.38 @ 25C.
Melting point: 220C to 222C.
Solubility: Soluble in water.
Storage: Room Temperature.

Proline USP Grade Specifications:
C5H9NO2 --- 115.13
l-Proline CAS 147-85-3
UNII: 9DLQ4CIU6V

DEFINITION
Proline contains NLT 98.5% and NMT 101.5% of l-proline (C5H9NO2), calculated on the dried basis.

IDENTIFICATION
A. Infrared Absorption
Residue on Ignition: NMT 0.4%
Chloride and Sulfate, Chloride: NMT 0.05%
Chloride and Sulfate, Sulfate: NMT 0.03%
Iron: NMT 30 ppm
Related impurities: To pass the test. Individual impurities : 0.5% maximum. Total impurities : 2.0% maximum.
Optical Rotation, Specific Rotation:
Sample solution: 40 mg/mL in water.
Acceptance criteria: −84.3° to −86.3°
Loss on Drying: Dry a sample at 105C for 3 h: it loses NMT 0.4% of its weight.

Proline BP Ph Eur Grade Specifications:
C5H9NO2 --- 115.1 CAS 147-85-3
Action and use: Amino acid.

DEFINITION
(2S)-Pyrrolidine-2-carboxylic acid.
Product of fermentation or of protein hydrolysis.
Content: 98.5 per cent to 101.0 per cent (dried substance).

CHARACTERS
Appearance: White or almost white, crystalline powder or colourless crystals.
Solubility: Very soluble in water, freely soluble in ethanol (96 per cent).

IDENTIFICATION
First identification: A, B
Second identification: A, C
A. Specific optical rotation.
B. Infrared absorption spectrophotometry.
C. Thin-layer chromatography.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

MUBY CHEMICALS
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TEL: (OFFICE) +912223770100, +912223726950
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L-Proline or (S)-Pyrrolidine-2-carboxylic Acid
SDS Sheet, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 12-Sept-23

Product Name & Other Names: L-Proline or (S)-Pyrrolidine-2-carboxylic Acid.
CAS No.: 147-85-3 or 4305-67-3
EINECS EC Code: 205-702-2
Molecular Weight: 115.13
Chemical Formula: C5H9NO2
Relevant uses and uses advised against (if any): Industrial Manufacturing.
SUPPLIER: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Hazards not otherwise classified (HNOC):
May cause mild skin irritation.
May cause mild eye irritation.
May cause mild respiratory irritation.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

Product Name & Other Names: L-Proline or (S)-Pyrrolidine-2-carboxylic Acid.
CAS No.: 147-85-3 or 4305-67-3
EINECS EC Code: 205-702-2

Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Contact medical center quickly. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: Check for and remove any contact lenses. Immediately flush your eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Get medical attention.

Combustible at high temperature. High heat or direct flame is necessary to cause ignition. Toxic fumes, carbon monoxide and nitrogen oxides may be formed in fire.
Explosion: At high temperature, explosive vapor-air mixtures may be formed.
Fire Extinguishing Media: Dry chemical, foam, water spray or carbon dioxide. Do not use a solid stream of water since the stream will scatter and spread the fire. Water spray may be used to keep fire exposed containers cool.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and a suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: Mop and pick up the material and place in an appropriate waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill: Avoid dust formation. Keep away from heat. Keep away from sources of ignition. Provide ventilation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Keep away from heat and source of fire. Store in cold, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not breathe dust. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing material. Storage: Room Temperature.

Airborne Exposure Limits: The product does not contain any relevant quantities of materials with critical values that have to be monitored at the workplace.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to the substance is apparent and engineering controls are not feasible, consult an industrial hygienist. For emergencies, or instances where the exposure levels are not known, use a full-face piece positive-pressure, air-supplied respirator. WARNING: Air purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron, or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or a full-face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: White odorless crystals or powder.
Odor: Odorless.
Odor threshold: Not available.
pH: 5-7 @ 20°C for 100 g/L in water.
Melting point: 220C to 222C.
Boiling point: Not available.
Relative density: 1.35-1.38 @ 25C.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Freely soluble in water and in absolute alcohol.
Viscosity: Not available.
Molecular Weight: 115.13
Chemical Formula: C5H9NO2

Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, nitrogen oxides and toxic fumes may form when heated to decomposition.
Hazardous Polymerization: Not reported. However, it can explode under certain conditions.
Incompatibilities: Strong oxidizing agents, heat, and sparks.
Conditions to Avoid: Heat, flames, sunlight, ignition sources and incompatibles.

LD50 Oral - Rat - >5.110 mg/kg.
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as possible or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Teratogenic Effects: Not available.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.

Toxicity to daphnia and other aquatic invertebrates: static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h.
Mobility: Likely to be mobile due to water solubility.
Biodegradability: Expected to be biodegradable
Results of PBT and vPvB assessment: No data available for assessment.

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of containers and unused contents in accordance with federal, state, and local requirements.

DOT USA & ADR/RID Europe: Not regulated.
IMDG/IMO: Not regulated.
IATA/ICAO: Not regulated.

USA:
SARA 311/312 Hazards: See section 2.
California Prop. 65 Components: This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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