Papain powder or Papaya proteinase I Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Papain powder, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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Papain powder or Papaya proteinase I: CAS Number: 9001-73-4, EINECS EC Number: 232-627-2, Molecular Formula: NA, Molecular Weight: NA, HS Code ---**

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Papain powder or Papaya proteinase I.

Papain also known as Papaya proteinase I is a proteolytic enzyme extracted from the raw fruit of the papaya plant. Proteolytic enzymes help break proteins down into smaller protein fragments called peptides and amino acids. This is why papain is a popular ingredient in meat tenderizer. Papain is a popular folk remedy to reduce pain, inflammation, and swelling. It has also been used to improve digestion and to treat infections, diarrhea, and allergies. Papain may also ease digestive symptoms like constipation and bloating. Papain is used in cosmetics, toothpaste, contact lens cleaners, meat tenderizers, meat products, animal feed and poultry feed.

General Properties and Specifications of Papain powder also known as Papaya proteinase I:
Physical Appearance: Off-white to light-yellow colored amorphous powder.
pH: 4 To 7
Solubility: Soluble in water. Forms clear solution.
TPC: 50‘000 cfu/g maximum.
Coliforms: 30 cfu/g maximum.
E. Coli: Absent.
Salmonella: Absent.
Storage: 2C to 8C. Short term shipping may be at room temperature.

DEFINITION
Papain is a purified proteolytic substance derived from Carica papaya Linné (Fam. Caricaceae). Papain, prepared as directed in the Assay, contains NLT 6000 Units/mg. Papain of a higher digestive power may be reduced to the official standard by admixture with papain of lower activity, lactose, or other suitable diluents.
One USP Unit of Papain activity is that which releases the equivalent of 1 micro-g of tyrosine from a specified casein substrate under the conditions of the Assay, using the enzyme concentration that liberates 40 micro-g of tyrosine per mL of Sample solution.

ASSAY
Casein Digestive Power:
To pass the test.
Acceptance criteria: NLT 6000 Units/mg

pH:
Sample solution: 1 in 50
Acceptance criteria: 4.8–6.2
Loss on Drying:
Analysis: Dry under vacuum at 60C for 4 h.
Acceptance criteria: NMT 7.0%
Packaging and Storage: Preserve in tight, light-resistant containers, and store in a cool place.

MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +912223770100, +912223726950
Current Date Time in India GMT+5:30

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neighbouring buyers may
e-mail: us@mubychem.com
Call toll-free 1-877-682-9243 (1-877-MUBYCHEM)

Exporters to USA Canada UAE Europe South Africa Tanzania Kenya Uganda Egypt Nigeria Turkey Mexico Brazil Argentina Chile Dubai etc.

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Papain powder or Papaya proteinase I SDS or Safety Data Sheet
Material Safety Data Sheet 11-Nov-20

Product Name & Other Names: Papain powder or Papaya proteinase I.
CAS No.: 9001-73-4
EINECS EC Number: 232-627-2
Relevant uses and uses advised against (if any): Industrial use only.
Supplier: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Skin corrosion/irritation Category 2 - H315
Serious eye damage/eye irritation Category 2A - H319
Sensitization, respiratory Category 1 - H334
Specific target organ toxicity, single exposure; Respiratory tract irritation Category 3 - H335

Hazard statement(s)
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H335 May cause respiratory irritation
Precautionary statement(s) Prevention
P261 Avoid breathing dust/fumes.
P271 Use only outdoors or in a well-ventilated area.
P285 In case of inadequate ventilation wear respiratory protection.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
Precautionary statement(s) Response
P304+341 IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P312 Call a POISON CENTER/doctor/physician/first aider/if you feel unwell.
P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor/physician/first aider.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313 If eye irritation persists: Get medical advice/attention.
P302+P352 IF ON SKIN: Wash with plenty of water and soap.
P332+P313 -If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
Precautionary statement(s) Storage
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Precautionary statement(s) Disposal
P501 Dispose of contents/container in accordance with local regulations.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbols:
Xi = Irritant
Xn = Harmful
Risk Phrases:
R36/37/38 Irritating to eyes, respiratory system, and skin
R42 May cause sensitization by inhalation.

Product Name & Other Names: Papain powder or Papaya proteinase I.
CAS No.: 9001-73-4
EINECS EC Number: 232-627-2

Eye Contact: Wash out immediately with fresh running water. Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by occasionally lifting the upper and lower lids. Seek medical attention without delay; if pain persists or recurs seek medical attention. Removal of contact lenses after an eye injury should only be undertaken by skilled personnel.
Skin Contact: Immediately remove all contaminated clothing, including footwear. Flush skin and hair with running water (and soap if available). Seek medical attention in event of irritation.
Inhalation: Lay patient down. Keep warm and rested. Prostheses such as false teeth, which may block airway, should be removed, where possible, prior to initiating first aid procedures. Apply artificial respiration if not breathing, preferably with a demand valve resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if necessary. Transport to hospital, or doctor, without delay.
Ingestion: If swallowed do NOT induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain open airway and prevent aspiration. Observe the patient carefully. Never give liquid to a person showing signs of being sleepy or with reduced awareness i.e. becoming unconscious. Give water to rinse out mouth, then provide liquid slowly and as much as casualty can comfortably drink. Seek medical advice.
Indication of any medical attention and special treatment needed: Treat symptomatically

Extinguishing media: Water spray or fog, Foam, Dry chemical powder, BCF (where regulations permit), Carbon dioxide.
Fire Fighting: Alert Fire Brigade and tell them location and nature of hazard. Wear breathing apparatus plus protective gloves. Prevent, by any means available, spillage from entering drains or water courses. Use water delivered as a fine spray to control fire and cool adjacent area. DO NOT approach containers suspected to be hot. Cool fire exposed containers with water spray from a protected location. If safe to do so, remove containers from path of fire.
Fire/Explosion Hazard: Combustible solid which burns but propagates flame with difficulty; it is estimated that most organic dusts are combustible - according to the circumstances under which the combustion process occurs, such materials may cause fires and / or dust explosions. Avoid generating dust, particularly clouds of dust in a confined or unventilated space as dusts may form an explosive mixture with air, and any source of ignition, i.e. flame or spark, will cause fire or explosion.
Combustion products include: Carbon monoxide (CO), carbon dioxide (CO2) and nitrogen compounds. May emit poisonous and corrosive fumes.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Ensure adequate ventilation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage:
Minor Spills: Remove all ignition sources. Clean up all spills immediately. Avoid contact with skin and eyes. Control personal contact with the substance, by using protective equipment. Use dry clean up procedures and avoid generating dust. Place in a suitable, labeled container for waste disposal.
Major Spills: Alert Emergency Services and tell them location and nature of hazard. Control personal contact by wearing protective clothing. Recover product wherever possible. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite).
IF DRY: Use dry clean up procedures and avoid generating dust. Collect residues and place in sealed plastic bags or other containers for disposal.
IF WET: Vacuum/shovel up and place in labelled containers for disposal.
ALWAYS: Wash area down with large amounts of water and prevent runoff into drains.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Store protected from heat, sparks and ignition sources and incompatible materials like oxidizers. Recommended storage temperature 2C - 8C. Short term shipping may be at room temperature. Hygroscopic. Light sensitive.

Airborne Exposure Limits: This product does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved): If the exposure limit is exceeded, a full face piece respirator with dust/mist filter may be worn. For emergencies or instances where the exposure levels are not known, use a full-face piece positive-pressure, air-supplied respirator. WARNING: Air purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: Off-white to light-yellow colored amorphous powder.
Odor: Not available.
Odor threshold: Not available.
pH: 4 to 7
Relative density: Not available.
Melting point / freezing point (°C): Not available.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility in water (g/L): Soluble in water. Forms clear solution
Viscosity (cSt): 35 poise

Chemical stability:
Product is considered stable. Unstable in the presence of incompatible materials.
Hazardous polymerization: Will not occur.
Conditions to avoid- Heat sparks flame moisture and incompatibilities.
Incompatible materials- Oxidizing agents
Hazardous decomposition products- Carbon monoxide (CO), carbon dioxide (CO2) and nitrogen compounds. May emit poisonous and corrosive fumes.

Toxicity to Animals: LD50 Oral – Rat: > 4.000 mg/kg
Mutagenicity: Data Not Available to make classification
Carcinogenicity: Not a reported carcinogen as per IARC, ACGIH, NTP & OSHA.
Reproductivity: Data Not Available to make classification

Toxicity:
Persistence and Degradability: Unlikely to persist.
Mobility: No information available.
Bioaccumulation/ Accumulation: Unlikely to accumulate.
Mobility in soil: Likely to be mobile due to water solubility.
Results of PBT and vPvB assessment: No data available for assessment.

Return empty containers to supplier for reuse/ recycling if possible. Legislation addressing waste disposal requirements may differ by country, state and/ or territory. Each user must refer to laws operating in their area. In some areas, certain wastes must be tracked. Dispose according to law.
In all cases disposal to sewer may be subject to local laws and regulations and follow the same.

DOT USA, TDG Canada & ADR/RID Europe: Not Regulated.
IMDG/IMO: Not Regulated.
IATA: Not Regulated.

SARA 302: Not listed.
SARA 313: Not listed.
SARA 311/312 Hazards: Acute Health Hazard. See section 2.
California Prop. 65 Components: This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.

European Labeling in Accordance with EC Directives:
H315-Causes skin irritation.
H319 -Causes serious eye irritation.
H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H335-May cause respiratory irritation.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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