Midazolam USP BP Ph Eur EP IP Grade Manufacturers, with SDS GHS MSDS Sheet |
Supplier, Manufacturer, Exporter of Midazolam USP BP Ph Eur EP IP Grade, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy Portugal, Bangladesh, etc. The products are offered as per required specifications and in correct shape and size in mm or meshs or microns as specified by the buyer. The participating units have one or more accreditations like FDA - cGMP and GLP approval, ISO-9001 Certified, "REACH" Registered, ISO-14001, ISO/IEC 17025, ISO-22000, FSSC 22000, ISO 45001, Kosher Certified, Halal Certified, HACCP, FSSAI. We offer Commercial Pure & IP BP EP Ph Eur USP NF JP FCC Food Grade Analytical Reagent Grades of Chemicals |
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Midazolam CAS Number 59467-70-8, EINECS EC Number: 261-774-5, Molecular Formula: C18H13ClFN3, Molecular Weight: 325.77, HS Code 29339100 or 29339153
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SDS MSDS Sheet of Midazolam Manufacturers
Midazolam
USP BP Ph Eur EP IP Grade Pure Suppliers
Midazolam is a fast-acting, short-duration benzodiazepine. It is primarily used for procedural sedation, anesthesia induction, and seizure management. Because it induces drowsiness, relieves anxiety, and causes short-term amnesia, it is frequently administered before surgeries or minor medical procedures.
General Properties and Specifications of Midazolam:
Appearance: White or yellowish, crystalline powder.
Assay: 98.5% minimum.
Melting Point: 161C to 164C. 158C to 164C is also reported in literature.
Solubility: Practically insoluble in water, freely soluble in acetone and in ethanol (96 per cent), soluble in methanol.
Storage: Preserve in tight, light-resistant containers. Preferably refrigerate 2C to 8C.
Midazolam USP Grade Specifications:
C18H13ClFN3 --- 325.77
4-H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl;
8-Chloro-6-(o-fluorophenyl)-1-methyl-4H -imidazo[1,5-a][1,4]benzodiazepine
CAS 59467-70-8
UNII: R60L0SM5BC
DEFINITION
Midazolam contains NLT 98.5% and NMT 101.5% of C18H13ClFN3, calculated on the dried basis.
IDENTIFICATION
A. Infrared Absorption.
B. The retention time of the major peak of the Sample solution corresponds to that of the Standard solution.
Residue on Ignition: NMT 0.1%
Organic Impurities; To pass the test by chromatography.
Loss on Drying: Dry a sample at 105C for 2 h: it loses NMT 0.5% of its weight.
Packaging and Storage: Preserve in tight, light-resistant containers.
Midazolam BP Ph Eur Grade Specifications:
C18H13ClFN3 --- 325.8 CAS 59467-70-8
Action and use: Benzodiazepine.
DEFINITION
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine.
Content: 98.5 per cent to 101.5 per cent (dried substance).
CHARACTERS
Appearance: White or yellowish, crystalline powder.
Solubility: Practically insoluble in water, freely soluble in acetone and in ethanol (96 per cent), soluble in methanol.
IDENTIFICATION
First identification: B
Second identification: A, C, D, E
A. Melting point: 161C to 164C.
B. Infrared absorption spectrophotometry.
C. Examine the chromatograms obtained in the test for impurity C.
D. Mix 90 mg with 0.30 g of anhydrous sodium carbonate and ignite in a crucible until an almost white residue is obtained (normally in less than 5 min). Allow to cool and dissolve the residue in 5 mL of dilute nitric acid. Filter (the filtrate is also used in identification test E). Add 1.0 mL of the filtrate to a freshly prepared mixture of 0.1 mL of alizarin S solution and 0.1 mL of zirconyl nitrate solution. Mix, allow it to stand for 5 min and compare the colour of the solution with that of a blank prepared in the same manner. The test solution is yellow, and the blank solution is red.
E. To 1 mL of the filtrate obtained in identification test D add 1 mL of water. The solution gives reaction (a) of chlorides.
TESTS
Appearance of solution: The solution is clear and not more intensely coloured than reference solution. Dissolve 0.1 g in 0.1 M hydrochloric acid and dilute to 10 mL with the same acid.
Related substances: To pass the test by Liquid chromatography.
Impurity C: To pass the test by Thin-layer chromatography.
Loss on drying: Maximum 0.5 per cent, determined on 1.000 g by drying in an oven at 105C for 2 h.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g in a platinum crucible.
Midazolam USP BP Ph Eur EP IP Grade is manufactured.
For Original Monographs of IP Indian Pharmacopoeia EP Ph Eur European Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.
We also manufacture and supply as under:
Manufacturers:
MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +91-22-65290100, +91-22-65290101
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Last 20 May, 2026
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Midazolam SDS, Safety Data Sheet
MSDS, Material Safety Data Sheet 20-May-26
1. Product Identification
Product Name & Other Names: Midazolam.
CAS No.: 59467-70-8
EINECS Number: 261-774-5
Molecular Weight: 273.72
Chemical Formula: C18H13ClFN3
Relevant uses and uses advised against (if any): Laboratory Chemicals and Industrial Use only.
Supplier: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute oral toxicity Category 3 H301
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements Toxic |
Signal Word: Danger
Hazard statements:
H301: Toxic if swallowed.
Precautionary statements:
P202: Do not handle until all safety precautions have been read and understood.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P264: Wash … thoroughly after handling.
P270: Do not eat, drink, or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P330: Rinse mouth.
P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a comfortable position for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332+313: If skin irritation occurs: Get medical advice/attention.
P337+313: If eye irritation persists get medical advice/attention.
P405: Store locked up.
P501: Dispose of contents/container to authorized agents only.
Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
T = Toxic
Risk Phrase:
R25 Toxic if swallowed.
3. Composition/Information on Ingredients
Product Name & Other Names: Midazolam.
CAS No.: 59467-70-8
EINECS Number: 261-774-5
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: If inhaled, remove to fresh air. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Give large amounts of water to drink. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated clothing and shoes. Cold water may be used. Wash clothing & Shoes before reuse. Get medical attention.
Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush your eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention.
Notes to Physician: Treat symptomatically.
5. Fire Fighting Measures
Fire: Not combustible, however, it can burn at high temperature. Decomposes on heating emitting toxic fumes.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Use means suitable for extinguishing surrounding fire. Avoid heavy water stream. Cool containers with water spray until well after the fire is out. Avoid getting water inside containers.
Decomposition Products: Fumes, hydrogen chloride, chlorine, hydrogen fluoride, fluorine along with nitrogen oxides.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and a suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved people should evacuate to a safe place.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to legal requirements.
Large Spill: Wear respiratory protection. Avoid breathing vapors, mist, or gas. Ensure adequate ventilation. Keep people away from upwind of spill/leak. Evacuate personnel to safe areas. Pick up and arrange disposal without creating dust. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allowing it to evacuate as per law.
7. Handling and Storage
Do not breathe vapor/dust/mist. Do not get in eyes, on skin, or on clothing. Avoid dust formation. Do not ingest.
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling it. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents, acid, and bases. Storage: Preserve in tight, light-resistant containers. Preferably refrigerate 2C to 8C.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: Not established.
Engineering Controls: Showers, Eyewash stations, Ventilation systems.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. Physical and Chemical Properties
Appearance: White or yellowish, crystalline powder.
Odor: Not available.
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Melting Point: 161C to 164C. 158C to 164C is also reported in literature.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Practically insoluble in water, freely soluble in acetone and in ethanol (96 per cent), soluble in methanol.
Viscosity: Not available.
Molecular Weight: 273.72
Chemical Formula: C18H13ClFN3
10. Stability and Reactivity
Stability: Stable under ordinary conditions of use and storage. Reacts with (some) acids: release of toxic and corrosive gases/vapors (hydrochloric acid, chlorine hydrogen fluoride, fluorine).
Hazardous Decomposition Products: Fumes, hydrogen chloride, chlorine hydrogen fluoride, fluorine along with nitrogen oxides may be released.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidants, acid, and bases.
Conditions to Avoid: Heat, Direct sunlight, Moisture, and Incompatibles. Always avoid Strong acids, Strong alkalis, Oxidizing agents.
11. Toxicological Information
Acute toxicity: Toxic if swallowed.
LD50 Oral, Rat - 215 mg/kg
Carcinogenicity: Not classifiable as to its carcinogenicity to humans by IARC, ACGIH, NTP, or EPA.
Reproductive toxicity: No information found.
Developmental Effects: No information found.
Teratogenicity: No information found.
12. Ecological Information
Toxicity to fish: Not available.
Persistence and Degradability: Not available.
Mobility: Not available.
Results of PBT and vPvB assessment: Not available.
13. Disposal Considerations
Whatever cannot be saved for recovery, or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of containers and unused contents in accordance with federal, state, and local requirements.
14. Transport Information
DOT USA, TDG Canada & ADR/RID Europe:
UN number: 2811, Class: 6.1, Packing group: III.
Proper shipping name: Toxic solid, organic, n.o.s. (Midazolam).
IMDG/IMO & IATA/ICAO:
UN number: 2811, Class: 6.1, Packing group: III.
Proper shipping name: Toxic solid, organic, n.o.s. (Midazolam).
15. Regulatory Information
USA:
SARA 311/312 Hazard Categories: Chronic Health Hazard. See section 2.
California Proposition 65: This product does not contain Proposition 65 chemicals.
Section 16 - Additional Information
Labeling according to GHS & Regulation (EC) No 1272/2008
H301: Toxic if swallowed.
Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
T = Toxic
Risk Phrase:
R25 Toxic if swallowed.
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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