Indometacin or Indomethacin BP EP USP Grade Manufacturers, with SDS GHS MSDS Sheet |
Supplier, Manufacturer, Exporter of Indometacin or Indomethacin BP EP USP Grade, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy Portugal, Bangladesh, etc. The products are offered as per required specifications and in correct shape and size in mm or meshs or microns as specified by the buyer. The participating units have one or more accreditations like FDA - cGMP and GLP approval, ISO-9001 Certified, "REACH" Registered, ISO-14001, ISO/IEC 17025, ISO-22000, FSSC 22000, ISO 45001, Kosher Certified, Halal Certified, HACCP, FSSAI. We offer Commercial Pure & IP BP EP Ph Eur USP NF JP FCC Food Grade Analytical Reagent Grades of Chemicals |
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Indometacin or Indomethacin CAS Number 53-86-1, EINECS EC Number: 200-186-5, Molecular Formula: C19H16ClNO4, Molecular Weight: 357.79, HS Code 29420090
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SDS MSDS Sheet of Indometacin or Indomethacin Manufacturers
Indometacin
Indomethacin BP EP USP Grade Suppliers
Indometacin or Indomethacin is a potent nonsteroidal anti-inflammatory drug (NSAID) used to relieve moderate to severe pain, fever, swelling, and stiffness from conditions like arthritis, gout, bursitis, and tendinitis.
General Properties and Specifications of Indometacin or Indomethacin:
Appearance: White or yellow, crystalline powder.
Assay; 98% minimum.
Melting Point: 158C to 162C literature.
Solubility: Practically insoluble in water, sparingly soluble in ethanol (96 per cent).
Storage: Preserve in well-closed, light-resistant containers.
Indomethacin USP Grade Specifications:
C19H16ClNO4 --- 357.79
1H -Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-;
1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
CAS 53-86-1
UNII: XXE1CET956
DEFINITION
Indomethacin contains NLT 98.0% and NMT 102.0% of indomethacin (C19H16ClNO4), calculated on the dried basis.
IDENTIFICATION
A. Infrared Absorption.
B. Ultraviolet Absorption.
C. X-Ray Diffraction.
Assay: 98% minimum.
Residue on Ignition: NMT 0.2%
Organic Impurities: To pass the test by chromatography.
Loss on Drying: Dry at a pressure below 5 mm of mercury at 100C for 2 h. Acceptance criteria: NMT 0.5%
Packaging and Storage: Preserve in well-closed, light-resistant containers.
Indometacin BP Ph Eur Grade:
C19H16ClNO4 --- 357.8 CAS 53-86-1
Action and use: Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory.
DEFINITION
2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid.
Content: 98.0 per cent to 102.0 per cent (dried substance).
CHARACTERS
Appearance: White or yellow, crystalline powder.
Solubility: Practically insoluble in water, sparingly soluble in ethanol (96 per cent).
IDENTIFICATION
First identification: A, C
Second identification: A, B, D, E
A. Melting point: 158C to 162C.
B. Ultraviolet and visible absorption spectrophotometry.
C. Infrared absorption spectrophotometry.
D. Dissolve 0.1 g in 10 mL of ethanol (96 per cent), heating slightly if necessary. To 0.1 mL of the solution add 2 mL of a freshly prepared mixture of 1 volume of a 250 g/L solution of hydroxylamine hydrochloride Rand 3 volumes of dilute sodium hydroxide solution. Add 2 mL of dilute hydrochloric acid and 1 mL of ferric chloride solution and mix. A violet-pink colour develops.
E. To 0.5 ;mL of the solution in ethanol (96 per cent) prepared in identification test D, add 0.5 mL of dimethylaminobenzaldehyde solution. A precipitate is formed that dissolves on shaking. Heat on a water-bath. A bluish-green colour is produced. Continue to heat for 5 min and cool in iced water for 2 min. A precipitate is formed and the colour changes to light greyish-green. Add mL of ethanol (96 per cent). The solution is clear and violet-pink in colour.
TESTS
Related substances: Passes the test by Liquid chromatography.
Loss on drying: Maximum 0.5 per cent, determined on 1 g by drying in an oven at 105C.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
Storage: Protected from light.
Indometacin or Indomethacin EP Grade is also offered.
For Original Monographs of IP Indian Pharmacopoeia EP Ph Eur European Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.
We also manufacture and supply as under:
Manufacturers:
MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +91-22-65290100, +91-22-65290101
Current Date Time in India GMT+5:30
e-mail: info@mubychem.com
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Call toll-free 1-877-682-9243 (1-877-MUBYCHEM)
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Last 12 May, 2026
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Indometacin or Indomethacin SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 12-May-26
Section 1. Product Information
Product Name/Trade Name: Indometacin or Indomethacin.
CAS No.: 53-86-1
EINECS EC Number: 200-186-5
Chemical Formula: C19H16ClNO4
Molecular Weight: 357.79
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
Section 2: Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 2), H300
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements Toxic |
Signal Words: Danger
Hazard statements:
H300 Fatal if swallowed.
Precautionary statements:
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P270: Do not eat, drink, or smoke when using this product.
P281: Use personal protective equipment as required.
P330: Rinse mouth.
P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P308+313: IF exposed or concerned: Get medical advice/attention.
P405: Store locked up.
P501: Dispose of contents/container in accordance with local/regional/national/international regulation.
Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
T+ Toxic
Risk Phrase:
R28 Very toxic if swallowed.
Section 3: Composition and Information on Ingredients
Product Name/Trade Name: Indometacin or Indomethacin.
CAS No.: 53-86-1
EINECS EC Number: 200-186-5
Section 4. First Aid & Procedure
Always get medical attention after the first aid is over.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin: Immediately flush skin with plenty of water for at least 15 minutes. Remove and wash contaminated clothing and shoes before reusing. Get medical attention if irritation develops.
Eyes: Immediately flush eyes with plenty of water for 15 minutes, occasionally lifting upper and lower eyelids. Hold eyelids apart during irrigation. Get medical attention.
Inhalation: Remove people to fresh air. If breathing is difficult, give oxygen. If not breathing administer artificial respiration. Get medical attention.
Section 5. Fire Fighting Measures
Fire/Explosion: Not considered to be a fire and explosion hazard. However, it can burn at high temperature.
Extinguishing Medium: Water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Avoid solid water jet as it may scatter the fire.
Special hazards arising from the substance or mixture: Chlorine compounds, Carbon oxides & Nitrogen oxides, Fumes may evolve.
Fire Fighting Instructions: Use suitable protective equipment for surrounding fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes.
Section 6. Spills and Disposals
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Do not inhale dust, vapor, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allowing it to evacuate as per law.
Section 7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling it. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Storage: Preserve in well-closed, light-resistant containers.
Section 8. Exposure Controls & Personal Protection
Exposure Limits: This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies.
Engineering Controls: Use adequate exhaust ventilation to keep airborne concentrations below the allowable exposure limit.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
Section 9. Physical & Chemical Data
Physical State: White or yellow, crystalline powder.
Odor: Not available.
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Melting Point: 158C to 162C literature.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Practically insoluble in water, sparingly soluble in ethanol (96 per cent).
Viscosity: Not available.
Chemical Formula: C19H16ClNO4
Molecular Weight: 357.79
Section 10. Stability and Reactivity
Chemical Stability: Stable under recommended temperatures and pressures.
Incompatibility (Materials to Avoid): Oxidizing agents. Sensitive to light.
Conditions to Avoid: Incompatible materials, exposure to moist air or water, excessive heat, and light.
Hazardous Decomposition Products: Chlorine compounds, Carbon oxides, Nitrogen oxides, Fumes.
Hazardous Polymerization: Will not occur.
Section 11. Toxicological Information
Toxicity to Animals: LD50 Oral - Rat – 2.42 mg/kg.
Carcinogenicity: No data available.
Specific target organ toxicity: Fatal if swallowed.
Section 12. Ecological Information
Ecotoxicity: No data available.
Persistence and Degradability: No data available.
Mobility: No data available.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.
Environmental Precautions: DO NOT DISCHARGE into drains and rivers.
Section 13. Disposal Suggestions
Dispose of in accordance with all applicable local, state, and federal regulations at an approved waste disposal facility.
Section 14. Transport and Label Information
DOT USA, TDG Canada & ADR/RID Europe:
UN number: 2811
Hazard class: 6.1; Packing group: I
Proper shipping name: Toxic solid, organic, n.o.s. (1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H indole-3-acetic acid).
IMDG/IMO:
UN number: 2811
Hazard class: 6.1; Packing group: I
Proper shipping name: Toxic solid, organic, n.o.s. (1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H indole-3-acetic acid).
IATA:
UN number: 2811
Hazard class: 6.1; Packing group: I
Proper shipping name: Toxic solid, organic, n.o.s. (1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H indole-3-acetic acid).
Section 15. Regulatory Information
USA:
SARA 311/312: Chronic Health Hazard.
Section 16. Other Information
European Labeling in Accordance with EC Directives:
H300 Fatal if swallowed.
Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
T+ Toxic
Risk Phrase:
R28 Very toxic if swallowed.
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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