Acid Yellow 73 or Fluorescein Sodium USP BP Ph Eur Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Acid Yellow 73 or Fluorescein Sodium USP BP Ph Eur, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy Portugal, Bangladesh, etc.

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Acid Yellow 73 or Fluorescein Sodium CAS Number 518-47-8, EINECS EC Number: 208-253-0, Molecular Formula: C20H10Na2O5, Molecular Weight: 376.27, HS Code 32059000 or 32129090

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Acid Yellow 73 or Fluorescein Sodium.

General Properties and Specifications of Fluorescein Sodium or Acid Yellow 73:
Appearance: Orange-red powder. Hygroscopic.
Odor: Odorless
Assay: >98%
Relative Density: about 1.6
Melting Point: >300C literature.
Boiling Point: 663C literature.
Flash Point: 217C literature.
Solubility: Soluble in water.
Storage: Room temperature. Preferably refrigerate.

Fluorescein Sodium BP Ph Eur Grade Specifications:
Soluble Fluorescein
C20H10Na2O5 --- 376.3 CAS 518-47-8
Action and use: Detection of corneal lesions, retinal angiography and pancreatic function testing.

CHARACTERS
Appearance: Orange-red, fine powder, hygroscopic.
Solubility: Freely soluble in water, soluble in ethanol (96 per cent), practically insoluble in hexane and in methylene chloride.

IDENTIFICATION
First identification: B, D
Second identification: A, C, D
A. Dilute 0.1 mL of solution S (see Tests) to 10 mL with water. The solution shows yellowish-green fluorescence. The fluorescence disappears on addition of 0.1 mL of dilute hydrochloric acid and reappears on addition of 0.2 mL of dilute sodium hydroxide solution.
B. Infrared absorption spectrophotometry.
C. The absorption by a piece of filter paper of 0.05 mL of the solution prepared for identification A (before the addition of dilute hydrochloric acid) colours the paper yellow. On exposing the moist paper to bromine vapour for 1 min and then to ammonia vapour, the colour becomes deep pink.
D. Ignite 0.1 g in a porcelain crucible. Dissolve the residue in 5 mL of water and filter. 2 mL of the filtrate gives reaction (a) of sodium.

TESTS
Solution S: Dissolve 1.0 g in carbon dioxide-free water prepared from distilled water and dilute to 50 mL with the same solvent.
Appearance of solution: Solution S is clear and orange-yellow with yellowish-green fluorescence.
pH:7.0 to 9.0 for solution S.
Related substances: To pass the test by liquid chromatography.
Chlorides: Maximum 0.25 per cent.
Sulfates: Maximum 1.0 per cent.
Zinc: Dilute 5 mL of solution S to 10 mL with water. Add 2 mL of hydrochloric acid, filter and add 0.1 mL of potassium ferrocyanide solution. No turbidity or precipitate is formed immediately.
Loss on drying: Maximum 10.0 per cent, determined on 1.000 g by drying in an oven at 105C.

Fluorescein Sodium USP Grade Specifications:
C20H10Na2O5 --- 376.27
Benzoic acid, 2-(6-hydroxy-3-oxo-3H -xanthene-9-yl), sodium salt (1:2);
Fluorescein disodium salt CAS 518-47-8
UNII: 93X55PE38X
UNII: TPY09G7XIR

DEFINITION
Fluorescein Sodium contains NLT 90.0% and NMT 102.0% of fluorescein sodium (C20H10Na2O5), calculated on the anhydrous basis.

IDENTIFICATION
A. A solution is strongly fluorescent, even in extreme dilution. The fluorescence disappears when the solution is made acid and reappears when the solution is again made alkaline.
B. Identification Tests—General, Sodium: The residue remaining after incineration meets the requirements.
C. The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.

Zinc:
Sample solution: 10 mg/mL of Fluorescein Sodium in a saturated solution of sodium chloride.
Analysis: To 10 mL of Sample solution add 2 mL of 3 N hydrochloric acid. Shake well, filter, and add 1 mL of potassium ferrocyanide to the filtrate.
Acceptance criteria: No turbidity is produced.
Acriflavine:
Sample solution: 2 mg/mL of Fluorescein Sodium in water. Swirl the mixture, and filter.
Analysis: To the Sample solution add a few drops of 100-mg/mL sodium salicylate solution.
Acceptance criteria: No precipitate is formed.
Organic Impurities: To pass the test by chromatography.
Water Determination: NMT 17.0%
Packaging and Storage: Preserve in tight containers.

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Fluorescein Sodium or Acid Yellow 73 SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 29-Jul-24

Product Name & Other Names: Fluorescein Sodium or Acid Yellow 73.
CAS Number: 518-47-8
EINECS EC Number: 208-253-0
Molecular Weight: 376.27
Molecular Formula: C20H10Na2O5
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Hazards not otherwise classified (HNOC):
May causes mild skin irritation.
May causes mild eye irritation.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

Product Name & Other Names: Fluorescein Sodium or Acid Yellow 73.
CAS Number: 518-47-8
EINECS EC Number: 208-253-0

Emergency and First Aid Procedures:
Eyes - Flush with water for at least 15 minutes, raising and lowering eyelids occasionally. Get medical attention if irritation persists.
Skin - Thoroughly wash exposed area for at least 15 minutes. Remove contaminated clothing. Launder contaminated clothing before reuse. Get medical attention if irritation persists.
Ingestion - If swallowed, if conscious, give plenty of water. Immediately call a physician. Never give anything by mouth to an unconscious person.
Inhalation - Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Get medical attention.

Extinguisher Media: Water spray. Carbon dioxide (CO2). Dry chemical. alcohol-resistant foam.
Flammable Limits in Air % by Volume: N/A
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and a suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Do not inhale vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Room temperature. Preferably refrigerate.

Exposure Guidelines: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies. Better keep it under 10 mg/m3
Respiratory Protection (Specify Type): None needed under normal conditions of use with adequate ventilation. NIOSH approved equipment should be worn if PELs are exceeded.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: Orange-red powder. Hygroscopic.
Odor: Odorless.
Odor threshold: Not applicable.
pH: Not available.
Relative density: about 1.6
Melting point/freezing point: >300C literature.
Initial boiling point and boiling range: 663C literature.
Flash point: 217C literature.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Soluble in water
Viscosity: Not available.
Molecular Weight: 376.27
Molecular Formula: C20H10Na2O5

Stability: Stable under normal conditions.
Conditions to Avoid: Heat and Strong oxidizing agents. Avoid moisture.
Incompatibility (Materials to Avoid): Strong oxidizing.
Hazardous Decomposition Products: Carbon oxides, Sodium oxide.
Hazardous Polymerization: Will not occur.

LD50 Oral - Rat - 6720 mg/kg.
Carcinogenicity: No product present at levels greater than or equal to 0.1% is identified as probable, possible, or confirmed human carcinogen by NTP, ACGIH & OSHA. It is a Group 3: Not classifiable as to its carcinogenicity to humans as per IARC.
Teratogenic Effects: Not available.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: Not available.

Toxicity to fish: LC50 - Ictalurus catus (catfish) - 2.267 mg/l - 96 h.
Toxicity to daphnia and other aquatic invertebrates: static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h.
Persistence and Degradability: Unlikely to persist due to water solubility.
Mobility: Likely to be mobile due to water solubility.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.

Waste Disposal Methods: Dispose in accordance with all applicable Federal, State and Local regulations.

DOT USA, TDG Canada & ADR/RID Europe: Not regulated.
IMDG/IMO: Not regulated.
IATA: Not regulated.

USA:
SARA 311/312 Hazards: No SARA Hazards
California Prop. 65 Components: This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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