Dorzolamide Hydrochloride or Dorzolamide HCl BP Ph Eur USP EP Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Dorzolamide HCl or Dorzolamide Hydrochloride BP Ph Eur USP EP Grade, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy Portugal, Bangladesh, etc.

The products are offered as per required specifications and in correct shape and size in mm or meshs or microns as specified by the buyer.

The participating units have one or more accreditations like FDA - cGMP and GLP approval, ISO-9001 Certified, "REACH" Registered, ISO-14001, ISO/IEC 17025, ISO-22000, FSSC 22000, ISO 45001, Kosher Certified, Halal Certified, HACCP, FSSAI. We offer Commercial Pure & IP BP EP Ph Eur USP NF JP FCC Food Grade Analytical Reagent Grades of Chemicals

Bookmark this Web Site -- or -- Email This Page Info to a Colleague or Yourself

Search our website here:

---------

Export to USA UAE Europe Africa Tanzania Kenya Egypt Turkey Jumbo Packing; Exports to USA UAE Europe Africa Tanzania Kenya Uganda Egypt Turkey Brazil Chile Argentina Dubai etc. Packing Palletized and Shrink Wrapped; 25kg or 50kg or 55 lbs HDPE laminated bags with an extra HMHDP liner Drum Packing for better transportation Drum Packing & Palletized Liquid Chemical Export Import Air Freighting

Dorzolamide HCl or Dorzolamide Hydrochloride CAS Number 130693-82-2, EINECS EC Number: 620-304-2, Molecular Formula: C10H17ClN2O4S3, Molecular Weight: 360.90, HS Code 29359000 or 29350090

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Dorzolamide HCl or Dorzolamide Hydrochloride.

General Properties and Specifications of Dorzolamide Hydrochloride or Dorzolamide HCl:
Appearance: White or almost white crystalline powder.
Assay: >99%
Melting Point: 285C literature.
Solubility: Soluble in water.
Storage: Room Temperature. Recommended in a cool and dark place, <15C. Refrigeration should be preferred. Short-term shipping may be ambient.

Dorzolamide Hydrochloride USP Grade Specifications:
C10H16N2O4S3-HCl --- 360.90
4H -Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, monohydrochloride, (4S -trans)-;
(4S ,6S )-4-(Ethylamino)-5,6-dihydro-6-methyl-4H -thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide, monohydrochloride CAS 130693-82-2
UNII: QZO5366EW7
UNII: 9JDX055TW1

DEFINITION
Dorzolamide Hydrochloride contains NLT 99.0% and NMT 101.0% of dorzolamide hydrochloride (C10H16N2O4S3-HCl), calculated on anhydrous basis.

IDENTIFICATION
A. Infrared Absorption
B. The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.
C. Identification Tests - General, Chloride.

Residue on Ignition: NMT 0.1%, an ignition temperature of 600C being used.
Organic Impurities: To pass the test by chromatography.
Limit of Dorzolamide Hydrochloride Related Compound A: To pass the test by chromatography. Acceptance criteria: NMT 0.5%
Water Determination: on 0.4 g. Acceptance criteria: NMT 0.5%
Packaging and Storage: Preserve in well-closed containers, protected from light, and store at 15C to 30.

Dorzolamide Hydrochloride BP Ph Eur Grade Specifications:
C10H17ClN2O4S3 --- 360.9 CAS 130693-82-2
Action and use: Carbonic anhydrase inhibitor; treatment of glaucoma and ocular hypertension.

DEFINITION
(4S,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride.
Content: 99.0 per cent to 101.0 per cent (dried substance).

CHARACTERS
Appearance: White or almost white, crystalline powder.
Solubility: Soluble in water, slightly soluble in methanol, very slightly soluble in anhydrous ethanol. It shows polymorphism.

IDENTIFICATION
A. Infrared absorption spectrophotometry.
B. It complies with the test for impurity A (see Tests).
C. It gives reaction (a) of chlorides.

TESTS
Impurity A: To pass the test by Liquid chromatography. --- maximum 0.5 per cent.
Related substances: To pass the test by Liquid chromatography.
Loss on drying: Maximum 0.5 per cent, determined on 1.000 g by drying in an oven at 105C.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.

For Original Monographs of IP Indian Pharmacopoeia EP Ph Eur European Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +912223770100, +912223726950
Current Date Time in India GMT+5:30

USA, Canada, Mexico and other American
neighbouring buyers may
e-mail: us@mubychem.com
Call toll-free 1-877-682-9243 (1-877-MUBYCHEM)

Exporters to USA Canada UAE Europe South Africa Tanzania Kenya Uganda Egypt Nigeria Turkey Mexico Brazil Argentina Chile Dubai etc.

Global or International Suppliers, Exporters, Importers, Manufacturers

I shall pass through this world, but once. If therefore, there is any good that I can do, or if there is any favor that I can show to a fellow human being, let me do it now. Let me not defer or neglect it. For I shall not tread this way again

Dorzolamide Hydrochloride or Dorzolamide HCl SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 09-Jan-25

Product Name & Other Names: Dorzolamide Hydrochloride or Dorzolamide HCl.
CAS No.: 130693-82-2
EINECS, EC Number: 620-304-2
Molecular Weight: 360.90
Chemical Formula: C10H17ClN2O4S3
Relevant uses and uses advised against (if any): Laboratory chemicals, Manufacture of substances
Supplier: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Acute toxicity, Oral (Category 4), H302
Specific target organ toxicity - repeated exposure (Category 2), H373

Hazard Statements:
H302: Harmful if swallowed.
H373: May cause damage to organs through prolonged or repeated exposure.

Precautionary Statements:
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P264 Wash thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
Xn Harmful
Risk Phrases:
R22 Harmful if swallowed.
R48 Danger of serious damage to health by prolonged exposure.

Product Name & Other Names: Dorzolamide Hydrochloride or Dorzolamide HCl.
CAS No.: 130693-82-2
EINECS, EC Number: 620-304-2

Eyes: Immediately flush your eyes with excess water for 15 minutes, lifting lower and upper eyelids occasionally.
Skin: Immediately flush skin with excess water for 15 minutes while removing contaminated clothing.
Ingestion: Call Emergency Medical immediately. Rinse your mouth with cold water. Give the victim 1-2 cups of water or milk to drink. Induce vomiting immediately.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration.

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemicals, or carbon dioxide. Avoid solid water jets as it can scatter the fire.
Protective equipment and precautions for firefighters: Use water spray, foam, or dry chemicals to extinguish fire. Firefighters should wear full firefighting turn-out gear and respiratory protection. Cool container with water spray. Material is not sensitive to impact or static discharge.
Special hazards arising from the substance: Carbon oxides, Nitrogen oxides (NOx), Sulfur oxides, Chlorine compounds.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved people should evacuate to a safe place.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Do not inhale dust, vapor, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allowing it to evacuate as per law.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling it. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep the container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Storage: Room Temperature. Recommended in a cool and dark place, <15C. Refrigeration should be preferred. Short-term shipping may be ambient.

Exposure guidelines: Not Available.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice.

Physical state and appearance: Crystalline white to off-white powder.
Odor: Not available.
Odor threshold: Not available.
pH (1% soln/water): Not available.
Relative density: Not available.
Melting Point: 285C literature.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Soluble in water.
Viscosity: Not available.
Molecular Weight: 360.90
Chemical Formula: C10H17ClN2O4S3

Stability: Stable under normal conditions of use and storage.
Incompatibility: Heat and strong oxidizing agents.
Hazardous Decomposition Products: Carbon oxides, Nitrogen oxides (NOx), Sulfur oxides, Chlorine compounds.
Hazardous Polymerization: Has not been reported.

LD50 Oral - Rat - 1927 mg/kg.
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
May causes damage to organs (Kidney) through prolonged or repeated exposure.
Reproductive Effects: No information available.
Developmental Effects: No information available.
Teratogenicity: No information available.

Toxicity to fish: No information available.
Results of PBT and vPvB assessment: This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
IATA & IMDG/IMO: Not dangerous goods.

USA:
SARA 311/312 Hazard Categories: Acute Health Hazard, Chronic Health Hazard
California Proposition 65: Not listed.

European Labeling in Accordance with EC Directives:
H302: Harmful if swallowed.
H373: May cause damage to organs through prolonged or repeated exposure.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
Xn Harmful
Risk Phrases:
R22 Harmful if swallowed.
R48 Danger of serious damage to health by prolonged exposure.

DISCLAIMER: The information and recommendations set forth herein are presented in good faith and believed correct as of the date hereof. It is compiled from various sources, and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules, or insurance requirements applicable. This MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a professionally trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.

Disclaimer:
**************************
Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
**************************

List of All the IP, BP, EP, Ph Eur, USP NF, JP, FCC Food, Analytical Reagent Grades of Chemicals
Best Seller Fast Moving IP, BP, EP, Ph Eur, USP NF, JP, FCC Food, Analytical Reagent Grades of Chemicals Ex-stock Items
Aluminum Chloride Hexahydrate	Aluminium Potassium Sulphate
Ammonium Bicarbonate	Ammonium Carbonate
Ammonium Chloride	Ammonium Persulfate
Borax; Sodium Borate	Boric Acid
Calcium Lactobionate	Calcium Saccharate
Calcium Sulfate	Carbamide Peroxide
Chromic Chloride	Cupric or Copper Chloride
Ferric Chloride Hexahydrate	Fumaric Acid
Glacial Acetic Acid	Lactobionic Acid
Magnesium Chloride	Magnesium Sulfate
Manganese Chloride	Manganese Sulfate
Potassium Bromide	Potassium Chloride
Potassium Hydroxide Pellets	Potassium Nitrate
Propylene Carbonate	Potassium Monopersulfate
Selenious acid	Sodium Acetate
Sodium Bromate	Sodium Diacetate
Sodium Formaldehyde Bisulfite	Sodium Lactobionate
Sodium Thiosulfate	Zinc Chloride