Diphenhydramine HCl or Diphenhydramine Hydrochloride USP BP EP Grade Manufacturers, with SDS GHS MSDS Sheet |
Supplier, Manufacturer, Exporter of Diphenhydramine HCl or Diphenhydramine Hydrochloride USP BP EP Grade, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy Portugal, Bangladesh, etc. The products are offered as per required specifications and in correct shape and size in mm or meshs or microns as specified by the buyer. The participating units have one or more accreditations like FDA - cGMP and GLP approval, ISO-9001 Certified, "REACH" Registered, ISO-14001, ISO/IEC 17025, ISO-22000, FSSC 22000, ISO 45001, Kosher Certified, Halal Certified, HACCP, FSSAI. We offer Commercial Pure & IP BP EP Ph Eur USP NF JP FCC Food Grade Analytical Reagent Grades of Chemicals |
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Diphenhydramine HCl or Diphenhydramine Hydrochloride CAS Number 147-24-0, EINECS EC Number: 205-687-2, Molecular Formula: C17H21NOClH, Molecular Weight: 291.82, HS Code 29221990
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SDS MSDS Sheet of Diphenhydramine HCl or Diphenhydramine Hydrochloride Manufacturers
Diphenhydramine Hydrochloride
Diphenhydramine HCl USP BP EP Grade Suppliers
Diphenhydraminhydrochlorid or Diphenhydramine hydrochloride is a first-generation H1-antihistamine used to treat allergies, insomnia, motion sickness, and cold symptoms.
General Properties and Specifications of Diphenhydramine Hydrochloride:
Appearance: White or almost-white crystalline powder.
Odor: Odorless.
Assay: >98%
Melting Point: 168C to 172C literature.
Solubility: Soluble in water. Soluble in Chloroform, Acetone, Alcohol.
Storage: Room Temperature (Recommended in a cool and dark place, <15°C).
Diphenhydramine Hydrochloride USP Grade Specifications:
C17H21NO-HCl --- 291.82
Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride;
2-(Diphenylmethoxy)-N,N-dimethylethylamine hydrochloride CAS 147-24-0
UNII: TC2D6JAD40
UNII: 8GTS82S83M
DEFINITION
Diphenhydramine Hydrochloride contains NLT 98.0% and NMT 102.0% of diphenhydramine hydrochloride (C17H21NO ·HCl), calculated on the dried basis.
IDENTIFICATION
A. Infrared Absorption
B. The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.
C. Identification Tests—General, Chloride.
Residue on Ignition: NMT 0.1%
Organic Impurities: To pass the test by chromatography.
Acidity or Alkalinity:
Sample solution: 50 mg/mL of Diphenhydramine Hydrochloride in carbon ioxide-free water
Analysis: To 10 mL of the Sample solution, add 0.15 mL of methyl red TS 2 and 0.25 mL of 0.01 N hydrochloric acid. The solution is pink. Titrate with 0.01 N sodium hydroxide.
Acceptance criteria: ;NMT 0.5 mL of 0.01 N sodium hydroxide is required to change the color of the solution to yellow.
Loss on Drying: Dry a sample at 105C for 3 h. Loss NMT 0.5%
Packaging and Storage: Preserve in tight, light-resistant containers. Store at room temperature.
Diphenhydramine Hydrochloride BP Ph Eur Grade Specifications:
C17H22ClNO --- 291.8 CAS 147-24-0
Action and use: Histamine H1 receptor antagonist; antihistamine.
Preparations:
Diphenhydramine Oral Solution
Diphenhydramine Tablets.
DEFINITION
2-(Diphenylmethoxy)-N,N-dimethylethanamine hydrochloride.
Content: 99.0 per cent to 101.0 per cent (dried substance).
CHARACTERS
Appearance: White or almost white, crystalline powder.
Solubility: Very soluble in water, freely soluble in ethanol (96 per cent).
IDENTIFICATION
First identification: C, D
Second identification: A, B, D
A. Melting point: 168C to 172C.
B. Ultraviolet and visible absorption spectrophotometry
C. Infrared absorption spectrophotometry.
D. It gives reaction of chlorides.
Solution S: Dissolve 1.0 g in carbon dioxide-free water and dilute to 20 mL with the same solvent.
Appearance of solution: Solution S and a fivefold dilution of solution S are clear. Solution S is not more intensely coloured than reference solution.
Acidity or alkalinity: To 10 mL of solution S add 0.15 mL of methyl red solution and 0.25 mL of 0.01 M hydrochloric acid. The solution is pink. Not more than 0.5 mL of 0.01 M sodium hydroxide is required to change the colour of the indicator to yellow.
Related substances: To pass the test by Liquid chromatography.
Loss on drying: Maximum 0.5 per cent, determined on 1.000 g by drying in an oven at 105C.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
We also offer Diphenhydramine Hydrochloride as per EP Grade Specifications.
For Original Monographs of IP Indian Pharmacopoeia EP Ph Eur European Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.
We also manufacture and supply as under:
Phenazopyridine Hydrochloride.
Manufacturers:
MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +91-22-65290100, +91-22-65290101
Current Date Time in India GMT+5:30
e-mail: info@mubychem.com
USA, Canada, Mexico and other American neighbouring buyers may
e-mail: us@mubychem.com
Call toll-free 1-877-682-9243 (1-877-MUBYCHEM)
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Last 29 April, 2026
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Diphenhydramine HCl or Diphenhydramine Hydrochloride
SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 29-April-26
1. Product Identification
Product Name/Synonyms: Diphenhydramine HCl or Diphenhydramine Hydrochloride
CAS No.: 147-24-0
EINECS EC Number: 205-687-2
Molecular Weight: 291.82
Chemical Formula: C17H21NOClH
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, oral Category 4
Labeling according to Regulation (EC) No 1272/2008
GHS Label Elements Irritant |
Signal Words: Warning
Hazard statements:
H302: Harmful if swallowed.
Precautionary statements:
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash skin thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P270: Do not eat, drink or smoke when using this product.
P273: Avoid release to the environment.
P330: Rinse mouth.
P362: Take off contaminated clothing and wash before reuse.
P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P332+313: If skin irritation occurs: Get medical advice/attention.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313 If eye irritation persists: Get medical advice/ attention.
P501: Dispose of contents/container to authorized agents only.
Labeling in accordance with Directive 67/548/EEC:
Hazard Symbol:
Xn Harmful
Risk Phrase:
R22: Harmful if swallowed.
3. Composition/Information on Ingredients
Product Name/Synonyms: Diphenhydramine HCl or Diphenhydramine Hydrochloride
CAS No.: 147-24-0
EINECS EC Number: 205-687-2
4. First Aid Measures
Inhalation: Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Keep a person warm and quiet; get medical attention.
Ingestion: Induce vomiting immediately if directed by medical personnel. Never give anything by mouth to an unconscious person.
Skin Contact: Immediately flush skin with plenty of soap and water for at least 15 minutes. Remove contaminated clothing and shoes. Wash clothing before reusing. Thoroughly clean shoes before reusing them. Get medical attention if irritation develops.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Get medical attention.
Notes to Physician: Treat symptomatically.
5. Fire Fighting Measures
Fire: It is not considered to be a fire hazard. However, it will burn at high temperature.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemicals, or carbon dioxide. Use water spray to cool fire-exposed containers. Avoid solid water jet as it can scatter the fire.
Special hazards arising from the substance or mixture: Carbon oxides, Nitrogen oxides (NOx), Chlorine compounds and Fumes.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Use personal protective equipment. Ventilate area of leak or spill. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment, cleanup procedures, and Storage: Contain spilled material. Pick up spills and place them in a suitable container for reclamation or disposal, using a method that does not generate dust.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wear personal protective equipment. Avoid ingestion and inhalation. Wash thoroughly after handling it. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep the container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original containers. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Avoid dust formation and control ignition sources. Storage: Room temperature. Short-term shipping may be ambient.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: None established.
Ventilation System: In general, dilution ventilation is a satisfactory health hazard control for this substance. However, if conditions of use create discomfort for the worker, a local exhaust system should be considered.
Personal Respirators (NIOSH Approved): Not expected to require personal respirator usage. For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator (NIOSH type N95 or better filters) may be worn. If oil particles (e.g., lubricants, cutting fluids, glycerin, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
9. Physical and Chemical Properties
Appearance: White or almost-white crystalline powder.
Odor: Odorless.
Odor threshold: Not applicable.
pH: Not available.
Relative density: Not available.
Boiling Point: Not available.
Melting Point: 168C to 172C literature.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Soluble in water. Soluble in Chloroform, Acetone, Alcohol.
Viscosity: Not available.
Molecular Weight: 291.82
Chemical Formula: C17H21NOClH
10. Stability and Reactivity
Stability: Stable under recommended conditions of use and storage.
Hazardous Decomposition Products: May produce oxides of nitrogen, carbon, chlorine compounds along with fumes when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents.
Conditions to Avoid: Heat, flame, ignition sources, dusting, and incompatibles.
11. Toxicological Information
Toxicity Data: LD50 Oral - Rat - 500 mg/kg.
Carcinogenic Effects: Not a reported carcinogen by IARC, NTP, ACGIH, OSHA.
Mutagenic Effects: No information available
Reproductive Effects: No information available.
Developmental Effects: No information available.
12. Ecological Information
Environmental Fate: Not available.
Persistence and degradability: Unlikely to persist.
Toxicity: No data available.
Bioaccumulative potential: No data available.
Mobility in soil: Likely to be mobile.
PBT and vPvB assessment: No data available.
13. Disposal Considerations
Whatever cannot be saved for recovery, or recycling should be managed in an appropriate and approved waste disposal facility. Dispose of containers and unused material in accordance with legal requirements.
14. Transport Information
Land Transport DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
Sea Transport IMDG/IMO: Not dangerous goods.
Air Transport IATA/ICAO: Not dangerous goods.
15. Regulatory Information
USA:
SARA 311/312 Hazardous Categorization: Acute Health Hazard.
California Proposition 65: This product does not contain any Proposition 65 chemicals.
16. Other Information
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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