Dimethyl Sulfoxide or DMSO or Methylsulfinylmethane or Methyl Sulfoxide BP Ph Eur EP USP Reagent Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Dimethyl Sulfoxide or DMSO BP Ph Eur EP USP Reagent Grade, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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Dimethyl Sulfoxide or DMSO or Methylsulfinylmethane or Methyl sulfoxide: CAS Number: 67-68-5, EINECS EC Number: 200-664-3, Molecular Formula: C2H6OS or (CH3)2SO, Molecular Weight: 78.13, HS Code ---**

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Dimethyl Sulfoxide or DMSO or Methylsulfinylmethane or Methyl sulfoxide.

Dimethyl sulfoxide or DMSO or or Methylsulfinylmethane or Methyl sulfoxide is an organosulfur compound with the formula (CH3)2SO. This colorless liquid is used as a polar aprotic solvent that dissolves both polar and nonpolar compounds and is miscible in a wide range of organic solvents as well as water. DMSO is predominantly used as a topical analgesic, a vehicle for topical application of pharmaceuticals, as an anti-inflammatory, and an antioxidant. Dimethyl Sulfoxide is commonly used in veterinary medicine as a liniment for horses, alone or in combination with other ingredients.

General Properties and Specifications of Dimethyl Sulfoxide or DMSO or Methylsulfinylmethane or Methyl sulfoxide:
Appearance: Colorless.
Assay: 99.8% minimum.
Odor: Almost odorless or say Slightly sulfurous odor.
Acid Value: 0.03 maximum.
Moisture: 0.10 maximum.
Relative density: 1.1
Melting point: 17C to 19C.
Boiling point: 189C.
Flash point: 87C minimum reported.
Auto-ignition temperature: 300C.
Solubility: Miscible with water. Soluble in ethanol, acetone, ether, carbon tetrachloride, ethyl acetate.

Specifications of Dimethyl Sulfoxide DMSO USP Grade:
C2H6OS -- 78.13
Methane, sulfinylbis-.
Methyl sulfoxide --- CAS 67-68-5.

Dimethyl Sulfoxide contains not less than 99.9 percent of C2H6OS, calculated on the anhydrous basis.

Packaging and storage: Preserve in tight, light-resistant containers.
Identification:
A: Infrared Absorption.
B: Add 1.5 mL cautiously and dropwise to 2.5 mL of hydriodic acid in a test tube cooled in ice. Filter the mixture rapidly and collect the precipitate. Dry the precipitate in vacuum: a deep violet, crystalline solid is obtained, and it is soluble in chloroform, yielding a red solution.
Specific gravity: between 1.095 and 1.101.
Refractive index: between 1.4755 and 1.4775.
Acidity: Dissolve 50.0 g in 100 mL of water and add phenolphthalein. If the solution remains colorless, titrate with 0.01 N sodium hydroxide until a pink color appears: not more than 5.0 mL of 0.01 N sodium hydroxide is consumed.
Water Determination: not more than 0.1%. [ note— Weigh and transfer the test specimen in an environment of low humidity to minimize absorption of atmospheric water.]
Ultraviolet absorbance: Maintain Dimethyl Sulfoxide in a water bath at a temperature of less than 20C [note— Do not freeze.], and purge with dry nitrogen for 30 minutes. Record the UV absorption spectrum between 270 and 350 nm in a 1-cm cell, using water as the blank: the spectrum is smooth with no absorption maxima; the absorbance at 275 nm is not more than 0.20, and the absorbance ratios, A 285 / A 275 and A 295 / A 275, at the wavelengths indicated by the subscripts, are not more than 0.65 and 0.45, respectively.
Limit of nonvolatile residue: Evaporate about 100.0 g to dryness in a tared, preconditioned dish on a hot plate under a suitable fume hood. Evaporate gently so boiling does not occur. The weight of the residue does not exceed 0.01%.
Related compounds: To pass the test by chromatography --- not more than 0.1% of total impurities is found.
Assay: Using the results from the test for Limit of nonvolatile residue and the test for Related compounds, calculate the percentage of C2H6OS in the portion of Dimethyl Sulfoxide taken by subtracting the percentage of nonvolatile residue and the percentage of total impurities found from 100.0%. [note— A correction for percent water is not applied to the result.]

Specifications of Dimethyl Sulfoxide BP Ph Eur Grade:
C2H6OS --- 78.1 --- 67-68-5
Action and use: Pharmaceutical solvent; excipient.
When dimethyl sulphoxide is demanded, Dimethyl Sulfoxide shall be supplied.

CHARACTERS
Appearance: Colourless liquid or colourless crystals, hygroscopic.
Solubility: Miscible with water and with ethanol (96 per cent).

IDENTIFICATION
First identification: C
Second identification: A, B, D
A. Relative density.
B. Refractive index.
C. Infrared absorption spectrophotometry.
Comparison dimethyl sulfoxide CRS.
D. Dissolve 50 mg of nickel chloride in 5 mL of the substance to be examined. The solution is greenish-yellow. Heat in a water-bath at 50C. The colour changes to green or bluish-green. Cool. The colour changes to greenish-yellow.

TESTS
Acidity: Dissolve 50.0 g in 100 mL of carbon dioxide-free water. Add 0.1 mL of phenolphthalein solution. Not more than 5.0 mL of 0.01 M sodium hydroxide is required to produce a pink colour.
Relative density: 1.100 to 1.104.
Refractive index: 1.478 to 1.480.
Freezing point: Minimum 18.3C.
Absorbance: Purge with nitrogen for 15 min. The absorbance, measured using water as the compensation liquid, is not more than 0.30 at 275 nm and not more than 0.20 at both 285 nm and 295 nm. Examined between 270 nm and 350 nm, the substance to be examined shows no absorption maximum.
Related substances: To pass the test by Gas chromatography.
Water: Maximum 0.2 per cent, determined on 10.0 g.

Specifications of Dimethyl Sulfoxide Analytical Reagent grade:
Methyl Sulfoxide
Sulfinylbismethane
(CH3)2SO --- Formula Weight 78.13
CAS Number 67-68-5

MAXIMUM ALLOWABLE
Residue after evaporation: 0.01%
Titrable acid: 0.001 meq/g
Water (H2O): 0.1%

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

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Dimethyl Sulfoxide or DMSO or Methylsulfinylmethane or Methyl sulfoxide SDS, Safety Data Sheet
MATERIAL SAFETY DATA SHEET 16-Oct-20

Product Name & Other Names: Dimethyl Sulfoxide or DMSO or Methylsulfinylmethane or Methyl sulfoxide.
CAS Number: 67-68-5
EINECS EC Number: 200-664-3
Molecular Formula: C2H6OS or (CH3)2SO
Molecular Weight: 78.13
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Flammable liquids (Category 4) H227
Labeling according to GHS & Regulation (EC) No 1272/2008

Precautionary statements (GHS-US):
P210: Keep away from heat, sparks, open flames, hot surfaces. - No smoking.
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352 - IF ON SKIN: Wash with plenty of soap and water.
P303+P361+P353 - IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P403+P235: Store in a well-ventilated place. Keep cool.
P405: Store locked up.
P273: Avoid release to the environment.
P501: Dispose of contents/container to comply with local, state, and federal regulations.
P337+313: If eye irritation persists get medical advice/attention.

Classification according to directive 67/548/EEC or Directive 1999/45/EC:
Hazard Symbol:
None
Risk Phrase:
R7 May cause fire.

Product Name & Other Names: Dimethyl Sulfoxide or DMSO or Methylsulfinylmethane or Methyl sulfoxide.
CAS Number: 67-68-5
EINECS EC Number: 200-664-3

Eye contact: Rinse immediately with plenty of water for 10 minutes at least. Contact a physician if symptoms persist.
Skin contact: Wash thoroughly with soap and water; flush with plenty of water. Take off spoilt clothes. Contact physician if symptoms persist.
Ingestion: Wash the mouth with water; seek medical advice immediately.
Inhalation: Remove from exposure site to fresh air and keep at rest. Obtain medical advice.

Flash point 87C minimum reported.
Auto-ignition temperature: 300C.
Extinguishing media recommended: CO2, foam, dry chemicals, water spray.
Hazardous combustion products: Carbon oxides, Sulfur Oxides and toxic fumes.
Non-recommended: Do not use direct water jet on burning material. Use water spray or fog.
Extinguishing procedures: Closed containers may build up pressure at elevated temperatures. If possible, containers should be cooled with a water spray. Closed containers may explode from heat of a fire.

Personal precautions, protective equipment, and emergency procedures: Ventilate area of leak or spill. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container. Avoid open flames or other sources of ignition.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like acid chlorides, phosphorus halides, strong acids, strong oxidizing agents, strong reducing agents. Keep air contact to a minimum.

Control parameters: Contains no substances with occupational exposure limit values.
Respiratory protection: Avoid to breath directly on the product. Apply local ventilations when appropriate.
Ventilation: Ensure good ventilation of the workstation.
Hand protection: Avoid skin contact. Use chemical resistant gloves as needed.
Eye protection: Use safety glasses.
Work / hygienic practices: Wash hands with soap and water after handling.

Appearance: Clear colorless liquid. It solidifies at about 19C.
Odor: Almost odorless or say Slightly sulfurous odor.
Odor threshold: Not available.
pH: Not available.
Relative density: around 1.1
Melting point/freezing point: 17C to 19C.
Initial boiling point and boiling range: 189C.
Flash point 87C minimum reported.
Auto-ignition temperature: 300C.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Miscible with water. Soluble in ethanol, acetone, ether, carbon tetrachloride, ethyl acetate
Viscosity: Not available.

Reactivity: Avoid heat, contact with strong acids, alkali, or oxidizers. Forms explosive mixtures with air on intense heating. Hygroscopic.
Risk of explosion with: Acetylidene, organic halides, perchlorates, Acid chlorides, nonmetallic halides, iron(III) compounds, nitrates, fluorides, chlorates, hydrides, perchloric acid, Oxides of phosphorus, Nitric acid, silver compounds, silicon compounds, silanes, acid halides.
Exothermic reaction with: Boron compounds, oxyhalogenic compounds, potassium, sodium, Strong oxidizing agents, phosphorus halides, strong reducing agents, acid chlorides, strong acids, silver salt, nitrogen dioxide.
Decomposition Carbon oxides, Sulfur Oxides and toxic fumes.
Polymerization: Will not occur.
Incompatible materials: Acid chlorides, phosphorus halides, strong acids, strong oxidizing agents, strong reducing agents.

LD 50 ORAL/RAT: 28300 mg/kg
LC50 INHALATION/ RAT - 4 h - > 5.33 mg/l
LD50 Dermal: 40000 mg/kg
Carcinogenicity: IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible, or confirmed human carcinogen by IARC.
Mutagenic Effects: Not available.
Teratogenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.

Toxicity to Fish: static test LC50 - Danio rerio (zebra fish) - > 25.000 mg/l - 96 h.
Toxicity to daphnia and other aquatic invertebrates: static test EC50 - Daphnia magna (Water flea) - 24.600 mg/l - 48 h.
Persistence and Degradability: Unlikely to persist due to water solubility.
Mobility: Likely to be mobile due to water solubility.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.

In accordance with local environmental laws. Avoid disposing into drainage systems and into the environment.

DOT (USA) & ADR/RID Europe: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods.

USA:
SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313: This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards: Fire Hazards, Acute Health Hazard. See section 2.
California Prop. 65 Components: This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.

European Labeling in Accordance with EC Directives:
H227: Combustible liquid.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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