Dextromethorphan Hydrobromide or Dextromethorphan HBr USP BP Ph Eur EP Grade Manufacturers, with SDS GHS MSDS Sheet |
Supplier, Manufacturer, Exporter of Dextromethorphan Hydrobromide or Dextromethorphan HBr USP BP Ph Eur EP Grade, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy Portugal, Bangladesh, etc. The products are offered as per required specifications and in correct shape and size in mm or meshs or microns as specified by the buyer. The participating units have one or more accreditations like FDA - cGMP and GLP approval, ISO-9001 Certified, "REACH" Registered, ISO-14001, ISO/IEC 17025, ISO-22000, FSSC 22000, ISO 45001, Kosher Certified, Halal Certified, HACCP, FSSAI. We offer Commercial Pure & IP BP EP Ph Eur USP NF JP FCC Food Grade Analytical Reagent Grades of Chemicals |
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Dextromethorphan Hydrobromide or Dextromethorphan HBr CAS Number 6700-34-1 monohydrate or 125-69-9 anhydrous, EINECS EC Number: 204-750-1, Molecular Formula: C18H26BrNO-H2O, Molecular Weight: 370.3, HS Code 29334910 or 29339900 or 29329990
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SDS MSDS Sheet of Dextromethorphan Hydrobromide Manufacturers
Dextromethorphan Hydrobromide
Dextromethorphan HBr USP BP Ph Eur EP Grade Suppliers
Dextromethorphan hydrobromide is a widely used over the counter (OTC) antitussive (cough suppressant) medication that temporarily relieves dry, non-productive coughs caused by colds or minor throat irritation. It works by reducing activity in the brain's cough center and is typically available as liquids, tablets, or lozenges, often as 15 mg or 30 mg strengths.
General Properties and Specifications of Dextromethorphan Hydrobromide:
Appearance: Almost white, crystalline powder.
Assay: 99% minimum.
Melting Point: About 125C, with decomposition.
Solubility: Sparingly soluble in water, freely soluble in ethanol (96 per cent).
Storage: Preserve in tight containers, protected from light.
Dextromethorphan Hydrobromide USP Grade Specifications:
C18H25NO-HBr-H2O --- 370.32
Morphinan, 3-methoxy-17-methyl-, (9α,13α,14α)-, hydrobromide, monohydrate;
3-Methoxy-17-methyl-9α,13α,14α-morphinan hydrobromide monohydrate CAS 6700-34-1
Anhydrous CAS 125-69-9 --- 352.32
UNII: 9D2RTI9KYH
UNII: Z0CG3115FG
DEFINITION
Dextromethorphan Hydrobromide contains NLT 98.0% and NMT 102.0% of dextromethorphan hydrobromide (C18H25NO-HBr), calculated on anhydrous basis.
IDENTIFICATION
A. Infrared Absorption
B. Chromatography.
Assay: 98% to 102%
Residue on Ignition: NMT 0.1%
Limit of Phenolic Compounds: To pass the test.
Limit of N,N-Dimethylaniline: To pass the test.--- NMT 0.001% of N,N-dimethylaniline.
pH: Sample solution: 10 mg/mL. Acceptance criteria: 5.2–6.5
Water Determination: 3.5%–5.5%
Packaging and Storage: Preserve in tight containers.
Dextromethorphan Hydrobromide BP Ph Eur Grade:
C18H26BrNO-H2O --- 370.3 CAS 6700-34-1
Action and use: Opioid receptor agonist; cough suppressant.
DEFINITION
ent-3-Methoxy-17-methylmorphinan hydrobromide monohydrate.
Content: 99.0 per cent to 101.0 per cent (anhydrous substance).
CHARACTERS
Appearance: Almost white, crystalline powder.
Solubility: Sparingly soluble in water, freely soluble in ethanol (96 per cent).
Melting Point: About 125C, with decomposition.
IDENTIFICATION
First identification: A, B, D
Second identification: A, C, D
A. Specific optical rotation.
Infrared absorption spectrophotometry.
C. Thin-layer chromatography.
D. It gives reaction of bromides.
TESTS
Solution S: Dissolve 1.0 g in ethanol (96 per cent) and dilute to 20 mL with the same solvent.
Appearance of solution: Solution S is clear and colourless.
Acidity or alkalinity: Dissolve 0.4 g in carbon dioxide-free water with gentle heating, cool and dilute to 20 mL with the same solvent. Add 0.1 mL of methyl red solution and 0.2 mL of 0.01 M sodium hydroxide. The solution is yellow. Not more than 0.4 mL of 0.01 M hydrochloric acid is required to change the colour of the indicator to red.
Specific optical rotation: + 28 to + 30 (anhydrous substance). Dissolve 0.200 g in 0.1 M hydrochloric acid and dilute to 10.0 mL with the same acid.
Related substances: To pass the test by Liquid chromatography.
N,N-Dimethylaniline: Maximum 10 ppm.
Water: 4.0 per cent to 5.5 per cent, determined on 0.200 g.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
Storage: Protected from light.
Dextromethorphan Hydrobromide EP Grade is also offered.
For Original Monographs of IP Indian Pharmacopoeia EP Ph Eur European Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.
We also manufacture and supply as under:
3-(Bromoacetyl)pyridine Hydrobromide
Manufacturers:
MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +91-22-65290100, +91-22-65290101
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Last 10 May, 2026
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Dextromethorphan Hydrobromide or Dextromethorphan HBr
SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 10-May-26
1. Product Identification
Product Name & Other Names: Dextromethorphan Hydrobromide or Dextromethorphan HBr.
CAS No.: 6700-34-1 monohydrate or 125-69-9 anhydrous
EINECS EC Number: 204-750-1
Molecular Formula: C18H26BrNO-H2O
Molecular Weight: 370.3
Relevant uses and uses advised against (if any): Laboratory and Industrial Use.
Supplier: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, oral (Category 4) H302
Serious Eye Damage/Eye Irritation (Category 2) H319
Specific target organ toxicity (single exposure) - Respiratory system (Category 3) H335
Labeling according to GHS USA & Regulation (EC) No 1272/2008
GHS Label Elements Irritant |
Signal Words: Warning
Hazard Statements:
H302: Harmful if swallowed.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary Statements:
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P264: Wash contaminated parts thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P301+P310: IF SWALLOWED: Immediately call a POSION CENTER or doctor/physician.
P302+352: IF ON SKIN: Wash with plenty of soap and water.
P303+361+353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+ 338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P333+313: If skin irritation or a rash occurs: Get medical advice/attention.
P362: Take off contaminated clothing and wash before reuse.
Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazards Symbols:
Xn = Harmful.
Xi = Irritant.
Risk Phrases:
R22 Harmful if swallowed.
R36/37 Irritating to eyes and respiratory system.
3. Composition/Information on Ingredients
Product Name & Other Names: Dextromethorphan Hydrobromide or Dextromethorphan HBr.
CAS No.: 6700-34-1 monohydrate or 125-69-9 anhydrous
EINECS EC Number: 204-750-1
Molecular Formula: C18H26BrNO-H2O
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Do not use mouth-to-mouth method if victim inhaled the substance. Induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Get medical attention.
Ingestion: Rinse mouth. Do not induce vomiting without medical advice. If vomiting occurs naturally, have victim lean forward to reduce risk of aspiration. Never give anything by mouth to a victim who is unconscious or is having convulsions. Get medical attention.
Skin Contact: Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes. Use a mild soap if available. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reusing. Thoroughly clean shoes before reusing them. For minor skin contact, avoid spreading material on unaffected skin.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
Notes to Physician: Treat symptomatically.
5. Fire Fighting Measures
Products of Combustion: Carbon oxides, nitrogen oxides, hydrogen bromide, and toxic fumes.
Fire Extinguishing Media: Water fog. Alcohol foam. Polymer foam. Dry chemical powder. Carbon dioxide (CO2). Avoid a solid water stream as it may scatter and spread fire. Fire residues and contaminated fire extinguishing water must be disposed of in accordance with local regulations. In the event of fire and/or explosion do not breathe fumes.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved people should evacuate to a safe place. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
6. Accidental Release Measures
Personal precautions: Ensure adequate ventilation. Keep people away from and upwind of spill/leak. Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist, or gas. Ensure adequate ventilation. Avoid breathing dust. Do not touch damaged containers or spilled material unless you wear appropriate protective clothing. Ventilate closed spaces before entering. Keep out of low areas.
Environmental precautions: Prevent further spillage if safe to do so. Do not contaminate water.
Methods for cleaning-up: Clean up in accordance with all applicable regulations. Should not be released into the environment.
Small Spill: Avoid dust/mist formation. Avoid breathing dust/mist. Ensure adequate ventilation. Clean contaminated surface thoroughly.
Large Spill: Sweep up and shovel. Keep in suitable, closed containers for disposal. Take care not to disperse material.
7. Handling and Storage
Precautions for safe handling: Avoid prolonged exposure. Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling it. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Provide appropriate exhaust ventilation at places where dust is formed. Do not handle or store near an open flame, heat, or other sources of ignition. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces. All equipment used when handling the product must be grounded. Use only with adequate ventilation.
Conditions for safe storage, including any incompatibility: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original containers. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing agents. Storage: Preserve in tight containers, protected from light.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: Contains no substances with occupational exposure limit established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. Physical and Chemical Properties
Appearance: Almost white, crystalline powder.
Odor: Not available.
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Melting point/Freezing point: About 125C, with decomposition.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Sparingly soluble in water, freely soluble in ethanol (96 per cent).
Viscosity: Not available.
Molecular Formula: C18H26BrNO-H2O
Molecular Weight: 370.3
10. Stability and Reactivity
Stability: It is stable under ordinary recommended of use and storage.
Hazardous Decomposition Products: It emits carbon oxides, nitrogen oxides, hydrogen bromide, toxic fumes when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Oxidizing agents. Alkalis.
Conditions to Avoid: Avoid moisture, light, heat, sparks, open flames, and other ignition sources. Contact with incompatible materials.
11. Toxicological Information
Eyes: Causes serious eye irritation.
Skin: Irritating in contact with skin.
Ingestion: Harmful if swallowed.
Inhalation: May be harmful if inhaled.
Toxicity data:
LD50/oral/rat = 350 mg/kg Oral LD50 Rat(for anhydrous form CAS number 125-69-9) LD50/oral/mouse = 165 mg/kg Oral LD50 Mouse Rat(for anhydrous form CAS number 125-69-9)
Carcinogenicity: Not expected to be hazardous by IARC, NTP, ACGIH, OSHA criteria.
Mutagenic Effects: No information available
Reproductive Effects: No information available.
Developmental Effects: No information available.
Teratogenicity: No information available.
12. Ecological Information
Toxicity to fish: Dextromethorphan Hydrobromide, Monohydrate - 6700-34-1 Freshwater Fish Species Data: 4.9 mg/l, 96 hours LC50 Rainbow Trout.
Environmental effects: Not available.
Persistence and degradability: No information available.
Mobility in soil: No information available.
Results of PBT and vPvB assessment: Not available.
13. Disposal Considerations
Whatever cannot be saved for recovery, or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of containers and unused contents in accordance with federal, state, and local requirements.
14. Transport Information
DOT USA, TDG Canada & ADR/RID Europe: Not regulated.
IMDG/IMO: Not regulated.
IATA/IMO: Not regulated.
15. Regulatory Information
USA:
SARA 311/312 Hazards: Acute Health Hazard.
California Prop. 65 Components: This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.
Section 16 - Additional Information
European Labeling in Accordance with EC Directives:
H302: Harmful if swallowed.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazards Symbols:
Xn = Harmful.
Xi = Irritant.
Risk Phrases:
R22 Harmful if swallowed.
R36/37 Irritating to eyes and respiratory system.
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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