Choline Bitartrate or Choline Acid Tartrate or Choline Hydrogen Tartrate or 2-(Hydroxyethyl)trimethylammonium bitartrate USP Dietary Supplement FCC Food Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Choline Bitartrate, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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Choline Bitartrate or Choline Acid Tartrate or Choline Hydrogen Tartrate or 2-(Hydroxyethyl)trimethylammonium bitartrate: CAS Number: 87-67-2, EINECS EC Number: 201-763-4, Molecular Formula: C9H19NO7 or [HOCH2CH2N (CH3)3]C4H5O6, Molecular Weight: 253.25, HS Code ---**

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Choline Bitartrate or Choline Acid Tartrate or Choline Hydrogen Tartrate or 2-(Hydroxyethyl)trimethylammonium bitartrate.

Choline Bitartrate is a basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism. It is a white crystalline powder, hygroscopic when exposed to air. It is odorless or has a faint trimethylamine-like odor with acidic taste. Choline Bitartrate is an essential nutrient, generally grouped as a B Vitamin. Although the body produces a small amount of choline, it is said that humans must consume some in the diet as well to maintain good health. For inclusion in supplements, manufacturers combine choline with a type of salt, such as bitartrate.

General specifications of Choline Bitartrate:
Melting point: 149C to 153C
Solubility: Freely sol in water; slightly sol in alcohol; insoluble in ether, chloroform and benzene.
Optical rotation: +17.5 to +18.5
1, 4-Dioxane: To pass the test
Lead (Pb): maximum 2 mg/kg
Residue on ignition: 0.1 %
pH(10% solution ): 3.0-4.0
Water: maximum 0.5 %.
Assay (C9H19NO7): minimum 98.0 %.

Choline Bitartrate USP Dietary Supplement Grade:
C9H19NO7 --- 253.25 --- 87-67-2
2-Hydroxyethanaminium,-N,N,N-trimethyl-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (1:1). (2-Hydroxyethyl)trimethylammonium-L-(+)-tartrate salt (1:1).
Choline Bitartrate contains not less than 99.0 percent and not more than 100.5 percent of C9H19NO7, calculated on the anhydrous basis.
Packaging and storage: Preserve in well-closed containers.

Identification:
A: Infrared Absorption.
B: Dissolve 1 g of Choline Bitartrate with 20 mL of water, and add 2 mL of potassium chloride solution (1 in 4). A white precipitate of potassium bitartrate is formed.
Specific rotation: between +17.5 and +18.5 .
pH: between 3.0 and 4.0, in a solution (1 in 10).
Water: not more than 0.5%.
Residue on ignition: not more than 0.1%.
Arsenic: the limit is 2 micro-gm per g.
Lead: not more than 0.3 micro-gm per g is found.
Heavy metals: 10 micro-gm per g.
Limit of total amines: not more than micro-gm per g.
Chromatographic purity: To pass the test.

Choline Bitartrate FCC Food Grade:
(2-Hydroxyethyl)trimethylammonium-L-(+)-tartrate Salt
[HOCH2CH2N (CH3)3]C4H5O6
C9H19NO7 Formula wt 253.25
INS: 1001(v) CAS: [87-67-2]

DESCRIPTION
Choline Bitartrate occurs as a white, hygroscopic, crystalline powder. It is freely soluble in water, slightly soluble in alcohol, and insoluble in ether and in chloroform.
Function: Nutrient.

REQUIREMENTS
Identification:
A. Dissolve 500 mg of sample in 2 mL of water, add 3 mL of 1 N sodium hydroxide, and heat to boiling. The odor of trimethylamine is detectable.
B. Dissolve 500 mg of sample in 2 mL of iodine. A red-brown precipitate forms immediately. Add 5 mL of 1 N sodium hydroxide. The precipitate dissolves, and the solution becomes clear yellow. Heat the solution. A pale yellow precipitate forms.
C. Add 1 mL of a 1:100 aqueous solution and 2 mL of a 1:50 solution of potassium ferrocyanide to 2 mL of cobaltous chloride. An emerald green color develops immediately.
Assay: Not less than 98.0% of C9H19NO7, calculated on the anhydrous basis.
1,4-Dioxane: Passes test.
Lead: Not more than 2 mg/kg.
Optical (Specific) Rotation: Between: 17.5° and 18.5°.
Residue on Ignition: Not more than 0.1%.
Water: Not more than 0.5%.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

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Choline Bitartrate SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 09-Oct-20

Product Name & Other Names: Choline Bitartrate or Choline Acid Tartrate or Choline Hydrogen Tartrate or 2-(Hydroxyethyl)trimethylammonium bitartrate.
CAS No.: 87-67-2
EINECS EC Number: 201-763-4
Molecular Weight: 253.25
Chemical Formula: C9H19NO7 or [HOCH2CH2N (CH3)3]C4H5O6
Relevant uses and uses advised against (if any): Industrial Manufacturing
SUPPLIER: As per Letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Hazards not otherwise classified (HNOC):
May causes mild skin irritation.
May Causes mild eye irritation.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

Product Name & Other Names: Choline Bitartrate or Choline Acid Tartrate or Choline Hydrogen Tartrate or 2-(Hydroxyethyl)trimethylammonium bitartrate.
CAS No.: 87-67-2
EINECS EC Number: 201-763-4

Inhalation: Remove to fresh air. Get medical attention for any breathing difficulty.
Ingestion: Do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing.
Skin Contact: Wash exposed area with soap and water. Get medical advice if irritation develops.
Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention.

Fire: Not considered to be a fire hazard. It can burn at high temperature.
Explosion: Not considered to be an explosion hazard.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Use means suitable for extinguishing surrounding fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage:
Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to legal requirements.
Large Spill: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law. Shut off all possible sources of ignition.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents, strong bases, acid anhydrides, acid chlorides. Hygroscopic.

Airborne Exposure Limits: None established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: Colorless or white powder.
Odor: Odorless.
Odor threshold: Not available.
pH: 3.0 - 4.4 at 50 g/l 20C
Relative density: around 1.98
Melting point: 149C to 153C
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Freely sol in water; slightly sol in alcohol; insoluble in ether, chloroform and benzene.
Viscosity: Not available.
Molecular Weight: 253.25
Chemical Formula: C9H19NO7 or [HOCH2CH2N (CH3)3]C4H5O6

Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: When heated to decomposition, substance may emit toxic fumes, oxides of carbon and nitrogen will evolve under fire condition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents, Strong bases, Acid anhydrides, Acid chlorides.
Conditions to Avoid: Incompatible products. Excess heat. Avoid dust formation. Exposure to moist air or water.
Hazardous Polymerization: Hazardous polymerization does not occur.

No LD50/LC50 information found relating to normal routes of occupational exposure.
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as probable or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Germ cell mutagenicity: Not available.
Reproductive toxicity: Not available.
Teratogenicity: Not available.

Toxicity: Not available.
Persistence and degradability: Not available.
Mobility in soil: Not available.
Bioaccumulative potential: Not available.
Results of PBT and vPvB assessment: Not available.

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused material in accordance with federal, state, and local requirements.

DOT USA: Not regulated as dangerous goods.
ADR/RID Europe: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods.

SARA 311/312: Acute: No; Chronic: No; Fire: No; Pressure: No; Reactivity: No (Pure / Solid).
SARA 313: Not applicable.
SARA 302: Not applicable.
California Proposition 65: This product does not contain any Proposition 65 chemicals

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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