α-Lipoic Acid or alpha-Lipoic Acid or Thioctic Acid IP BP Ph Eur EP USP Dietary Supplement Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of α-Lipoic Acid or alpha-Lipoic Acid or Thioctic Acid, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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α-Lipoic Acid or alpha-Lipoic Acid or Thioctic Acid CAS Number 1077-28-7 or ( also 1200-22-2), EINECS EC Number: 214-071-2, Molecular Formula: C8H14O2S2, Molecular Weight: 206.32, HS Code 29309099 or 29349990

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for α-Lipoic Acid or alpha-Lipoic Acid or Thioctic Acid.

α-Lipoic Acid or alpha-Lipoic Acid or Thioctic Acid, is an organosulfur compound derived from caprylic acid. It is also manufactured and is available as a dietary supplement, marketed as an antioxidant.

General Properties and Specifications of α-Lipoic Acid or alpha-Lipoic Acid or Thioctic Acid:
Appearance: Yellow Crystalline Powder.
Assay: 99%
Relative Density: about 1.29
Melting Point: 60C to 62C.
Boiling Point: 162C- 163C.
Solubility: Practically insoluble in water. Slightly soluble in methanol, chloroform and DMSO.
Storage: 2C to 8C refrigerate. OK to freeze. Short term shipping may be at ambient temperature. Protect from air and light.

Alpha Lipoic Acid USP Dietary Supplement Grade Specifications:
C8H14O2S2 --- 206.33
Thioctic acid;
1,2-Dithiolane-3-pentanoic acid;
1,2-Dithiolane-3-valeric acid CAS 1077-28-7

DEFINITION
Alpha Lipoic Acid contains NLT 99.0% and NMT 101.0% of C8H14O2S2 , calculated on the dried basis.

IDENTIFICATION
A. The retention time of the peak for alpha lipoic acid of the Sample solution corresponds to that of the Standard solution, as obtained in the& Assay.
B. Infrared Absorption
Residue on Ignition: Less than 0.1%
Chromatographic Purity, Procedure 1 and II: To pass the test.
Melting Range or Temperature: 60.0C to 62.0C.
Optical Rotation, Specific Rotation:
Sample solution: 50 mg/mL of Alpha Lipoic Acid, in dehydrated alcohol.
Acceptance criteria: –1.0° to +1.0°
Loss on Drying: Dry a sample in vacuum at 40C for 3 h: it loses NMT 0.2% of its weight.

Thioctic Acid BP Ph Eur Grade Specifications:
C8H14O2S2 --- 206.3 CAS 1077-28-7
Action and use: Antioxidant.

DEFINITION
5-[(3RS)-1,2-Dithiolan-3-yl]pentanoic acid.
Content: 97.0 per cent to 102.0 per cent (dried substance).

CHARACTERS
Appearance: Yellow, crystalline powder.
Solubility: Very slightly soluble in water, very soluble in dimethylformamide, freely soluble in methanol.
mp: About 61C.

For Original Monographs of IP Indian Pharmacopoeia EP Ph Eur European Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

MUBY CHEMICALS
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α-Lipoic Acid or alpha-Lipoic Acid or Thioctic Acid SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 28-Jan-24

Product Name & Other Names: α-Lipoic Acid or alpha-Lipoic Acid or Thioctic Acid.
CAS No.: 1077-28-7 or ( also 1200-22-2)
EINECS EC Number: 214-071-2
Molecular Formula: C8H14O2S2
Molecular Weight: 206.32
Relevant uses and uses advised against (if any): Laboratory and Industrial Use.
Supplier: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Acute toxicity, oral Category 4, H302
Skin corrosion/irritation Category 2, H315
Skin sensitization, Category 1, H317
Serious eye damage/eye irritation Category 2A, H319
Hazardous to the aquatic environment, long-term hazard Category 2, H411

Hazard Statements:
H302: Harmful if swallowed.
H315: Causes skin irritation.
H317: May cause an allergic skin reaction.
H319: Causes serious eye irritation.
H411: Toxic to aquatic life with long lasting effects.

Precautionary Statements:
P264: Wash contaminated parts thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310: IF SWALLOWED: Immediately call a POSION CENTER or doctor/physician.
P303+361+353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P333+313: If skin irritation or a rash occurs: Get medical advice/attention.
P403+233+235: Store in a well-ventilated place. Keep container tightly closed. Keep cool.
P362: Take off contaminated clothing and wash before reuse.
P391: Collect spillage.
P405: Store locked up.
P501: Dispose of contents/container in accordance with local/national regulation.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbols:
Xn Harmful
N Dangerous for the environment.
Risk Phrases:
R22 Harmful if swallowed.
R36/38: Irritating to eyes & skin.
R43: May cause sensitization by skin contact.
R51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.

Product Name & Other Names: α-Lipoic Acid or alpha-Lipoic Acid or Thioctic Acid.
CAS No.: 1077-28-7 or ( also 1200-22-2)
EINECS EC Number: 214-071-2
Molecular Formula: C8H14O2S2

Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Do not use mouth-to-mouth method if victim inhaled the substance. Induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Get medical attention.
Ingestion: Rinse mouth. Do not induce vomiting without medical advice. If vomiting occurs naturally, have victim lean forward to reduce risk of aspiration. Never give anything by mouth to a victim who is unconscious or is having convulsions. Get medical attention.
Skin Contact: Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes. Use a mild soap if available. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse. For minor skin contact, avoid spreading material on unaffected skin.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

Products of Combustion: Carbon oxides, sulfur oxides, and toxic fumes.
Fire Extinguishing Media: Water fog. Alcohol foam. Dry chemical. Polymer foam. Dry chemical powder. Carbon dioxide (CO2). Avoid a solid water stream as it may scatter and spread fire. Fire residues and contaminated fire extinguishing water must be disposed of in accordance with local regulations. In the event of fire and/or explosion do not breathe fumes.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Personal precautions: Ensure adequate ventilation. Keep people away from and upwind of spill/leak. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Ventilate closed spaces before entering. Keep out of low areas.
Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not contaminate water.
Methods for containment: Stop leak if you can do so without risk. Move containers to a safe and open area if the leak is irreparable.
Dike the spilled material, where this is possible. Prevent entry into waterways, sewers, basements, or confined areas.
Methods for cleaning up: Clean up in accordance with all applicable regulations. Should not be released into the environment.
Small Spill: Avoid dust/mist formation. Avoid breathing dust/mist. Ensure adequate ventilation. Wipe up with absorbent material (e.g., cloth, fleece). Clean contaminated surface thoroughly.
Large Spill: Dike far ahead of liquid spill for later disposal. Use a non-combustible material like vermiculite, sand, or earth to soak up the product and place into a container for later disposal. Storage: 2C to 8C refrigerate. OK to freeze. Short term shipping may be at ambient temperature. Protect from air and light.

Precautions for safe handling: Do not handle or store near an open flame, heat, or other sources of ignition. All equipment used when handling the product must be grounded. Use only with adequate ventilation. Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing agents.

Airborne Exposure Limits: Not established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: Yellow Crystalline Powder.
Odor: Not available.
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Boiling point: 243C to 246C literature.
Melting point/Freezing point: about 1.29
Flash point: 162C- 163C.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility (water): Practically insoluble in water. Slightly soluble in methanol, chloroform and DMSO.
Viscosity: Not available.
Molecular Formula: C8H14O2S2
Molecular Weight: 206.32

Stability: It is stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: It emits carbon oxides, sulfur oxides, and toxic fumes when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Oxidizing agents.
Conditions to Avoid: Avoid light, heat, sparks, open flames and other ignition sources. Contact with incompatible materials.

Skin: Harmful in contact with skin.
Ingestion: Harmful if swallowed.
Toxicity data:
LD50 Oral - Rat - 1190 mg/kg
Carcinogenicity: Not expected to be hazardous by IARC, OSHA criteria.
Sensitization: May cause sensitization by skin contact.
Mutagenic Effects: No information available
Reproductive Effects: No information available.
Developmental Effects: No information available.
Teratogenicity: No information available.

Toxicity to fish: static test LC50 - Danio rerio (zebra fish) - 43 - 96 mg/l - 96 h
Toxicity to daphnia & other aquatic invertebrates: static test EC50 - Daphnia magna (Water flea) - ca. 15,1 mg/l - 48 h.
Ecotoxicity: Components of this product have been identified as having potential environmental concerns.
Aquatic toxicity: May cause long-term adverse effects in the aquatic environment. Toxic to aquatic life. Discharge into the environment must be avoided.
Bioaccumulative potential: No information available.
Mobility in soil: No information available.
Results of PBT and vPvB assessment: No information available.

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state, and local requirements.

DOT USA, TDG Canada & ADR/RID Europe:
UN proper shipping name: Environmentally hazardous substance, solid, n.o.s. (alpha-Lipoic Acid)
UN number: 3077; Transport hazard class(es): 9; Packing group: III.
IMDG/IMO & IATA/ICAO:
UN proper shipping name: Environmentally hazardous substance, solid, n.o.s. (alpha-Lipoic Acid)
UN number: 3077; Transport hazard class(es): 9; Packing group: III.

USA:
SARA 311/312 Hazards: Acute Health Hazard. See section 2.
California Prop. 65 Components: Not listed.

European/International Regulations European Labeling in Accordance with EC Directives:
H302: Harmful if swallowed.
H315: Causes skin irritation.
H317: May cause an allergic skin reaction.
H319: Causes serious eye irritation.
H411: Toxic to aquatic life with long lasting effects.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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