D L Methionine or DL-2-amino-4-methylithio butanoic acid USP BP Ph Eur FCC Food Grade Manufacturers, with SDS GHS MSDS Sheet |
Supplier, Manufacturer, Exporter of Methionine or DL-2-amino-4-methylithio butanoic acid USP BP Ph Eur FCC Food Grade, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc. The products are offered as per required specifications and in correct shape and size in mm or meshs or microns as specified by the buyer. The participating units have one or more accreditations like FDA - cGMP and GLP approval, ISO-9001 Certified, "REACH" Registered, ISO-14001, ISO/IEC 17025, ISO-22000, FSSC 22000, ISO 45001, Kosher Certified, Halal Certified, HACCP, FSSAI. We offer Commercial Pure & IP BP EP Ph Eur USP NF JP FCC Food Grade Analytical Reagent Grades of Chemicals |
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D L Methionine or DL-2-amino-4-methylithio butanoic acid: CAS Number: 59-51-8 or 63-68-3 (L-isomer) or 348-67-4 (D-isomer), EINECS EC Number: 200-432-1 or 200-562-9 (L-isomer), Molecular Formula: C5H11NO2S, Molecular Weight: 149.21, HS Code ---**
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SDS MSDS Sheet of Methionine or DL-2-amino-4-methylithio butanoic acid Manufacturers
Methionine
USP BP Ph Eur FCC Food Grade DL-2-amino-4-methylithio butanoic acid Pure Suppliers
DL Methionine is an amino acid that produces several important molecules in your body. These molecules are essential for the proper functioning of your cells. Methionine essential amino acid in humans. It is largely used in animal feed.
General Properties and Specifications of Methionine or DL-2-amino-4-methylithio butanoic acid:
Appearance: Crystalline powder.
Odor: Faint.
Assay: 99% minimum.
Loss on drying: 0.3% maximum.
Ash content: 0.5% maximum.
pH (1% aqueous solution): 5.6 to 6.1
Relative density: 1.34 literature.
Melting point: 281C (Decomposes).
Solubility: Soluble in water.
Specifications of Methionine USP Grade:
C5H11NO2S --- 149.21
l-Methionine --- [63-68-3].
DEFINITION
Methionine contains NLT 98.5% and NMT 101.5% of l-methionine (C5H11NO2S), calculated on the dried basis.
IDENTIFICATION
Infrared Absorption
ASSAY
To pass the test.
Acceptance criteria: 98.5%–101.5% on the dried basis
Residue on Ignition: NMT 0.4%
Chloride and Sulfate, Chloride:
Acceptance criteria: NMT 0.05%
Chloride and Sulfate, Sulfate:
Acceptance criteria: NMT 0.03 %
Iron: NMT 30 ppm
Related Compounds: To pass the test.
Acceptance criteria: Any secondary spot of the Sample solution is not larger or more intense than the principal spot of the Standard solution.
Individual impurities: NMT 0.5%
Total impurities: NMT 2.0%
Optical Rotation, Specific Rotation:
Acceptance criteria: +22.4° to +24.7°
pH: 5.6–6.1
Loss on Drying: Dry a sample at 105C for 3 h: it loses NMT 0.3% of its weight.
Packaging and Storage: Preserve in well-closed containers.
Specifications of DL-Methionine BP Ph Eur Grade:
C5H11NO2S --- 149.2 --- 59-51-8
Action and use: Used in treatment of paracetamol overdose.
DEFINITION
DL-Methionine contains not less than 99.0 per cent and not more than the equivalent of 101.0 per cent of (2RS)-2-amino-4-(methylsulfanyl)butanoic acid, calculated with reference to the dried substance.
CHARACTERS
Almost white, crystalline powder or small flakes, sparingly soluble in water, very slightly soluble in alcohol. It dissolves in dilute acids and in dilute solutions of the alkali hydroxides.
It melts at about 270C (instantaneous method).
IDENTIFICATION
First identification: A, C
Second identification: B, C, D
A. Examine by infrared absorption spectrophotometry, comparing with the spectrum obtained with DL-methionine CRS. Dry the substances at 105C.
B. Examine the chromatograms obtained in the test for related substances. The principal spot in the chromatogram obtained with test solution (b) is similar in position, colour and size to the principal spot in the chromatogram obtained with reference solution (a).
C. Dissolve 2.50 g in 1 M hydrochloric acid and dilute to 50.0 mL with the same acid. The angle of optical rotation is -0.05° to + 0.05°.
D. Dissolve 0.1 g of the substance to be examined and 0.1 g of glycine in 4.5 mL of dilute sodium hydroxide solution. Add 1 mL of a 25 g/L solution of sodium nitroprusside. Heat to 40C for 10 min. Allow to cool and add 2 mL of a mixture of 1 volume of phosphoric acid and 9 volumes of hydrochloric acid. A deep red colour develops.
TESTS
Solution S: Dissolve 1.0 g in carbon dioxide-free water and dilute to 50 mL with the same solvent.
Appearance of solution: Solution S is clear and colourless.
pH: The pH of solution S is 5.4 to 6.1.
Related substances: To pass the test. --- (0.2 per cent).
Chlorides: Dissolve 0.25 g in 35 mL of water. Add 5 mL of dilute nitric acid and 10 mL of silver nitrate solution. Allow to stand protected from light for 5 min. Any opalescence in the solution is not more intense than that in a standard prepared at the same time in the same manner using a mixture of 10 mL of chloride standard solution (5 ppm Cl) and 25 mL of water (200 ppm). Examine the tubes laterally against a black background.
Sulfates: Dissolve 1.0 g in 20 mL of distilled water, heating to 60C. Cool to 10C and filter. 15 mL of the solution complies with the limit test for sulfates (200 ppm).
Loss on drying: Not more than 0.5 per cent, determined on 1.000 g by drying in an oven at 105C.
Sulfated ash: Not more than 0.1 per cent, determined on 1.0 g.
ASSAY
Dissolve 0.140 g in 3 mL of anhydrous formic acid. Add 30 mL of anhydrous acetic acid. Immediately after dissolution, titrate with 0.1 M perchloric acid, determining the end-point potentiometrically.
1 mL of 0.1 M perchloric acid is equivalent to 14.92 mg of C5H11NO2S.
STORAGE
Store protected from light.
Specifications of DL-Methionine FCC Food Grade:
DL-2-Amino-4-(methylthio)butyric Acid
CH3SCH2CH2CHCOOH NH2
C5H11NO2S Formula weight 149.21
CAS: [59-51-8]
DESCRIPTION
DL-Methionine occurs as white crystalline platelets or a powder. One gram dissolves in about 30 mL of water. It is soluble in dilute acids and in solutions of alkali hydroxides. It is very slightly soluble in alcohol, and practically insoluble in ether. It is optically inactive. The pH of a 1:100 aqueous solution is between 5.6 and 6.1.
Function: Nutrient.
Identification: The infrared absorption spectrum of the sample exhibits relative maxima at the same wavelengths as those of a typical spectrum as shown in the section on Infrared Spectra, using the same test conditions as specified therein.
Assay: Not less than 98.5% and not more than 101.5% of C5H11NO2S, calculated on the dried basis.
Lead: Not more than 5 mg/kg.
Loss on Drying: Not more than 0.5%.
Residue on Ignition: Not more than 0.1%.
For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.
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Manufacturers:
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Methionine or DL-2-amino-4-methylithio butanoic acid SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 17-Oct-20
1. PRODUCT DESCRIPTION
Product Name & Other Names: Methionine or DL-2-amino-4-methylithio butanoic acid.
CAS Number: 59-51-8 or 63-68-3 (L-isomer) or 348-67-4 (D-isomer)
EINECS EC Number: 200-432-1 or 200-562-9 (L-isomer)
Molecular Formula: C5H11NO2S
Molecular Weight: 149.21
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. HAZARD IDENTIFICATION
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Labeling according GHS & Regulation (EC) No 1272/2008
GHS Label Elements None |
Signal Words: None
Hazards not otherwise classified (HNOC):
May causes mild skin irritation.
May causes mild eye irritation.
Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352 - IF ON SKIN: Wash with plenty of soap and water.
P303+P361+P353 - IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.
3. COMPOSITION/INFORMATION ON INGREDIENTS
Product Name & Other Names: Methionine or DL-2-amino-4-methylithio butanoic acid.
CAS Number: 59-51-8 or 63-68-3 (L-isomer) or 348-67-4 (D-isomer)
EINECS EC Number: 200-432-1 or 200-562-9 (L-isomer)
4. FIRST AID MEASURES
Always get medical attention after the first aid is over.
Emergency and First Aid Procedures:
Eyes - Flush with water for at least 15 minutes, raising and lowering eyelids occasionally. Get medical attention if irritation persists.
Skin - Thoroughly wash exposed area for at least 15 minutes. Remove contaminated clothing. Launder contaminated clothing before reuse. Get medical attention if irritation persists.
Ingestion - If swallowed, if conscious, give plenty of water. Immediately call a physician.
Inhalation - Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Keep person warm, quiet, and get medical attention.
5. FIREFIGHTING PROCEDURES
Extinguisher Media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide..
Special Fire fighting Procedures: Firefighters should wear full protective equipment and NIOSH approved self-contained breathing apparatus.
Unusual Fire and Explosion Hazards: Heated to decomposition, however, toxic oxides of sulfur, oxides of nitrogen and oxides of carbon along with fumes may be evolved.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes.
6. SPILL OR LEAK PROCEDURES
Personal precautions, protective equipment and emergency procedures: Ventilate area of spill. Avoid creating dust. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil or water sources.
Methods and materials used for containment Cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container.
7. SPECIAL PRECAUTIONS
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat or smoke while handling. Provide appropriate exhaust ventilation at places where dust is formed. Avoid contact with skin, eyes and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing agents.
8. SPECIAL PROTECTION INFORMATION
Exposure limits: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Respiratory Protection (Specify Type): None needed under normal conditions of use with adequate ventilation. NIOSH approved equipment should be worn if PELs are exceeded.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. PHYSICAL DATA
Physical State: Almost white, crystalline powder or small flakes.
Odor: Faint.
Odor threshold: Not available.
pH: 5.6–6.1
Relative density: 1.34 literature.
Melting Point: 281C (Decomposes).
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility in Water: Soluble in water.
Viscosity: Not available.
Molecular Formula: C5H11NO2
Molecular Weight: 149.21
10. REACTIVITY DATA
Stability: Stable.
Conditions to Avoid: Dust generation, Incompatibles
Incompatibility (Materials to Avoid): Strong Oxidizing Agents.
Hazardous Decomposition Products: Oxides of sulfur, nitrogen and carbon along with fumes.
Hazardous Polymerization: Will not occur
11. TOXICITY DATA
Toxicity Data: LD50 Oral - Rat – 36 g/kg
Carcinogenicity: Not listed as carcinogen by IARC, ACGIH, OSHA and NTP.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.
12. ECOLOGICAL DATA
Toxicity to fish, daphnia and other aquatic invertebrates: No data available.
Persistence and Degradability: Likely to degrade.
Mobility: Likely to be mobile due to water solubility.
Results of PBT and vPvB assessment: No data available for assessment.
13. DISPOSAL INFORMATION
Waste Disposal Methods: Dispose in accordance with all applicable regulations.
14. TRANSPORT INFORMATION
DOT (USA) & ADT/RID Europe: Not dangerous goods
IMDG & IATA: Not dangerous goods.
15. REGULATORY INFORMATION
USA Regulations:
SARA 313: Not applicable
SARA 311/312 Hazard Categories: Not hazardous. See section 2 for more information
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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