Tiotropium bromide monohydrate Manufacturers, with SDS GHS MSDS Sheet |
Supplier, Manufacturer, Exporter of Tiotropium bromide monohydrate, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal etc. The products are offered as per required specifications and in correct shape and size in mm or meshs or microns as specified by the buyer. The participating units have one or more accreditations like FDA - cGMP and GLP approval, ISO-9001 Certified, "REACH" Registered, ISO-14001, ISO/IEC 17025, ISO-22000, FSSC 22000, ISO 45001, Kosher Certified, Halal Certified, HACCP, FSSAI. We offer Commercial Pure & IP BP EP Ph Eur USP NF JP FCC Food Grade Analytical Reagent Grades of Chemicals |
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Tiotropium bromide monohydrate: CAS Number: 139404-48-1 or 411207-31-3, EINECS EC Number: yyyyy, Molecular Formula: C19H24BrNO5S2 or C19H22BrNO4S2-H2O, Molecular Weight: 490.43, HS Code ---**
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SDS MSDS Sheet of Tiotropium bromide monohydrate Manufacturers
Tiotropium bromide monohydrate
Pure Suppliers
Properties and Specifications of Tiotropium bromide monohydrate:
Appearance: White to faint beige.
Assay: 99% minimum.
Melting point: 226C literature.
Solubility: Soluble in DMSO.
Solution of 0.2% in water: Clear.
Storage: 2C to 8C, Refrigerator.
Meets specifications of BP EP IP.
We manufacture and supply as under:
Tiotropium Bromide Monohydrate
Methyl 2-(benzyloxy)-5-(2-bromoacetyl)benzoate
2-Bromo-4’-benzyloxy-3-nitroacetophenone.
Manufacturers:
MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +912223770100, +912223726950
Current Date Time in India GMT+5:30
e-mail: info@mubychem.com
USA, Canada, Mexico and other American
neighbouring buyers may
e-mail: us@mubychem.com
Call toll-free 1-877-682-9243 (1-877-MUBYCHEM)
Copyright and Usual Disclaimer is Applicable.
Last
5 October, 2023
Exporters to USA Canada UAE Europe South Africa Tanzania Kenya Uganda Egypt Nigeria Turkey Mexico Brazil Argentina Chile Dubai etc.
Global or International Suppliers, Exporters, Importers, Manufacturers
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Tiotropium bromide monohydrate SDS Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 21-Nov-20
1. Product Identification
Product Name & Other Names: Tiotropium bromide monohydrate.
CAS No.: 139404-48-1 or 411207-31-3
EINECS EC Code: --
Chemical Formula: C19H24BrNO5S2 or C19H22BrNO4S2-H2O.
Molecular Weight: 490.43
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Skin corrosion/irritation (Category 2), H315
Serious eye damage/eye irritation (Category 2A), H319
Acute toxicity (inhalation) (Category 4), H332
Specific target organ toxicity - repeated exposure (Category 1), H372
Labeling according to GHS USA & Regulation (EC) No 1272/2008
| GHS Label Elements  Irritant |
GHS Label Elements |
Signal Word: Danger
Hazard Statements:
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H332 Harmful if inhaled
H372 Causes damage to organs through prolonged or repeated exposure.
Precautionary Statements
P202: Do not handle until all safety precautions have been read and understood.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P272: Contaminated work clothing should not be allowed out of the workplace.
P273: Avoid release to the environment.
P280-Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310+330: IF SWALLOWED: Rinse mouth and immediately call a POISON CENTER or doctor/physician.
P303+361+353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308+313: IF exposed or concerned: Get medical advice/attention.
P363: Wash contaminated clothing before reuse.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container in accordance with local/regional/national/international regulations.
Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbols:
Xi Irritant
Xn Harmful
Risk Phrases:
R20 Harmful by inhalation
R36/38 Irritating to eyes and skin.
R48 Danger of serious damage to health by prolonged exposure.
3. Composition/Information on Ingredients
Product Name & Other Names: Tiotropium bromide monohydrate.
CAS No.: 139404-48-1 or 411207-31-3
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: Remove the victim to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Contact medical center quickly. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Get medical attention.
5. Fire Fighting Measures
Auto ignition temperature: Not available.
Toxic fumes, carbon dioxide and carbon monoxide, nitrogen oxides and sulfur oxides may be formed in fire.
Fire Extinguishing Media: Dry chemical, foam or carbon dioxide and water spray jet. Use water spray to cool fire-exposed containers.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place. Use water spray to cool unopened containers. Keep product and empty container away from heat and sources of ignition.
6. Accidental Release Measures
Personal precautions, protective equipment and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil or water sources.
Methods and materials used for containment Cleanup procedures and Storage:
Small Spill: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Mop and pick up the material and place in an appropriate waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep up and remove to an approved disposal container. Avoid mist formation. Keep away from heat. Keep away from sources of ignition. Provide ventilation. Contact Environment Agency.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat or smoke while handling. Avoid contact with skin, eyes and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cold, dry and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents, strong acids and bases. Do not breathe mist or dust. Containers of may be hazardous when empty. Avoid contact. Storage: 2C to 8C, Refrigerator.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: Does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies. Keep low limits.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to the substance is apparent and engineering controls are not feasible, consult an industrial hygienist. For emergencies, or instances where the exposure levels are not known, use a full-face piece positive-pressure, air-supplied respirator. WARNING: Air purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. Physical and Chemical Properties
Appearance: White to faint beige.
Odor: Not available.
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Melting Point: 226C literature.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Soluble in DMSO.
Viscosity: Not available.
Chemical Formula: C19H24BrNO5S2 or C19H22BrNO4S2-H2O.
Molecular Weight: 490.43
10. Stability and Reactivity
Stability: Stable under ordinary conditions of use and storage with the stabilizer.
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, nitrogen oxides, sulfur oxides and toxic fumes may form when heated to decomposition.
Incompatibilities: Strong oxidizing agents, Strong acids and bases, heat and sparks.
Conditions to Avoid: Heat, flames, ignition sources and incompatibles.
11. Toxicological Information
Oral rat LD50: >2000 mg/kg, (Rat).
Carcinogenicity: Not listed as a carcinogen by any agency.
Mutagenic Effects: Not available.
Reproductive Effects: No information available.
Causes damage to organs through prolonged or repeated exposure.
12. Ecological Information
Environmental Toxicity: Toxic to fish and aquatic life.
Persistence and Degradability: No information available
Bioaccumulation/ Accumulation: No information available.
Mobility: No information available.
Results of PBT and vPvB assessment: Not available.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with law.
14. Transport Information
DOT USA, TDG Canada & ADR/RID Europe: Not regulated.
IMDG/IMO & IATA: Not regulated.
15. Regulatory Information
SARA 311/312 Hazardous Categorization: Acute Health Hazard, Chronic Health Hazard.
SARA 313: Not applicable.
California Proposition 65: This product does not contain any Proposition 65 chemicals.
Section 16 - Additional Information
European/International Regulations European Labeling in Accordance with EC Directives:
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H332 Harmful if inhaled
H372 Causes damage to organs through prolonged or repeated exposure.
Hazard Symbols:
Xi Irritant
Xn Harmful
Risk Phrases:
R20 Harmful by inhalation
R36/38 Irritating to eyes and skin.
R48 Danger of serious damage to health by prolonged exposure.
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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